Identification of 526 conserved metazoan genetic innovations exposes a new role for cofactor E-like in neuronal microtubule homeostasis.

Autor: Melissa Y Frédéric, Victor F Lundin, Matthew D Whiteside, Juan G Cueva, Domena K Tu, S Y Catherine Kang, Hansmeet Singh, David L Baillie, Harald Hutter, Miriam B Goodman, Fiona S L Brinkman, Michel R Leroux

Publikováno v: PLoS Genetics, Vol 9, Iss 10, p e1003804 (2013)

The evolution of metazoans from their choanoflagellate-like unicellular ancestor coincided with the acquisition of novel biological functions to support a multicellular lifestyle, and eventually, the unique cellular and physiological demands of diffe

Externí odkaz: https://doaj.org/article/970a1b14e7a94edaae35cab9d3880d41

Structural and Functional Characterization of a Hole-Hole Homodimer Variant in a 'Knob-Into-Hole' Bispecific Antibody

Autor: Milady R. Niñonuevo, Jennifer Zhang, Hongfang Liu, Victor F. Lundin, Dongsheng Lei, Kevin Lin, Gang Ren, Guanghui Han, Hui-Min Zhang, Wendy Sandoval, Ho Young Lee, Charlene Li, Ming Lei

Publikováno v: Analytical chemistry, vol 89, iss 24
Zhang, HM; Li, C; Lei, M; Lundin, V; Lee, HY; Ninonuevo, M; et al.(2017). Structural and Functional Characterization of a Hole-Hole Homodimer Variant in a "knob-Into-Hole" Bispecific Antibody. Analytical Chemistry, 89(24), 13494-13501. doi: 10.1021/acs.analchem.7b03830. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/9kv6t5sh

© 2017 American Chemical Society. Bispecific antibodies have great potential to be the next-generation biotherapeutics due to their ability to simultaneously recognize two different targets. Compared to conventional monoclonal antibodies, knob-into-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e5086ef8ddd0662eb68165fcf7596f
https://escholarship.org/uc/item/9kv6t5sh

Divergent Substrate-Binding Mechanisms Reveal an Evolutionary Specialization of Eukaryotic Prefoldin Compared to Its Archaeal Counterpart

Autor: Michel R. Leroux, José Berenguer, José J. Fernández, Victor F. Lundin, Paulino Gómez-Puertas, Peter C. Stirling, Jaime Martín-Benito, Jasminka Boskovic, José M. Valpuesta, Juan Gomez-Reino, Pablo Chacón

Publikováno v: Structure. 15:101-110

Prefoldin (PFD) is a molecular chaperone that stabilizes and then delivers unfolded proteins to a chaperonin for facilitated folding. The PFD hexamer has undergone an evolutionary change in subunit composition, from two PFDalpha and four PFDbeta subu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b5ebac9ab7116494e14e7c30f20d2fa
https://doi.org/10.1016/j.str.2006.11.006

Identification of 526 conserved metazoan genetic innovations exposes a new role for cofactor E-like in neuronal microtubule homeostasis

Autor: S. Y. Catherine Kang, Juan G. Cueva, Hansmeet Singh, Harald Hutter, Fiona S. L. Brinkman, Victor F. Lundin, Domena Tu, Michel R. Leroux, Melissa Y. Frédéric, David L. Baillie, Miriam B. Goodman, Matthew D. Whiteside

Publikováno v: PLoS Genetics
PLoS Genetics, Vol 9, Iss 10, p e1003804 (2013)

The evolution of metazoans from their choanoflagellate-like unicellular ancestor coincided with the acquisition of novel biological functions to support a multicellular lifestyle, and eventually, the unique cellular and physiological demands of diffe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d3e4cce661749259c2d4024e128166a
https://pubmed.ncbi.nlm.nih.gov/24098140

Quality control of cytoskeletal proteins and human disease

Autor: Peter C. Stirling, Michel R. Leroux, Victor F. Lundin

Publikováno v: Trends in biochemical sciences. 35(5)

Actins and tubulins are abundant cytoskeletal proteins that support diverse cellular processes. Owing to the unique properties of these filament-forming proteins, an intricate cellular machinery consisting minimally of the chaperonin CCT, prefoldin,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa2d92cd62bc3c72dc8a78b18093636
https://pubmed.ncbi.nlm.nih.gov/20116259