Transforming growth factor-beta mediates balance between inflammation and fibrosis during plaque progression

Autor: Marion J.J. Gijbels, Marjan Smook, Philip Gotwals, Victor E. Koteliansky, Peter Heeringa, Esther Lutgens, Mat J.A.P. Daemen

Publikováno v: Arteriosclerosis thrombosis and vascular biology, 22(6), 975-982. LIPPINCOTT WILLIAMS & WILKINS
Arteriosclerosis, thrombosis, and vascular biology, 22(6), 975-982. Lippincott Williams and Wilkins

The transition from stable to rupture-prone and ruptured atherosclerotic plaques involves many processes, including an altered balance between inflammation and fibrosis. An important mediator of both is transforming growth factor (TGF)-beta, and a pi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaffe37c182ed59cb51c2010688707d3
https://doi.org/10.1161/01.atv.0000019729.39500.2f

Muscle β1D Integrin Reinforces the Cytoskeleton–Matrix Link: Modulation of Integrin Adhesive Function by Alternative Splicing

Autor: Lorenzo Silengo, Fiorella Balzac, Alexey M. Belkin, Guido Tarone, Keith Burridge, S. Francesco Retta, Reinhard Fassler, Olga Y. Pletjushkina, Victor E. Koteliansky

Publikováno v: The Journal of Cell Biology

Expression of muscle-specific beta1D integrin with an alternatively spliced cytoplasmic domain in CHO and GD25, beta1 integrin-minus cells leads to their phenotypic conversion. beta1D-transfected nonmuscle cells display rounded morphology, lack of ps

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db717fcfc29161e408461aa385a22a4f
https://doi.org/10.1083/jcb.139.6.1583

Deletion of Integrin α1 by Homologous Recombination Permits Normal Murine Development but Gives Rise to a Specific Deficit in Cell Adhesion

Autor: Humphrey Gardner, Victor E. Koteliansky, Rudolf Jaenisch, Jordan A. Kreidberg

Publikováno v: Developmental Biology. 175(2):301-313

Integrin alpha 1 is a receptor for laminin and collagen which is expressed widely and dynamically in embryogenesis and has been implicated in various developmental processes including establishment of the placenta and formation of the central and per

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aafc3dd6c580d92ceeb66d5076e127cb

Beta 1D integrin displaces the beta 1A isoform in striated muscles: localization at junctional structures and signaling potential in nonmuscle cells

Autor: Alexey M. Belkin, Fiorella Altruda, Victor E. Koteliansky, Guido Tarone, Fiorella Balzac, Alfred Maier, Natalia I. Zhidkova, Keith Burridge, Daniela Tomatis

Publikováno v: The Journal of Cell Biology

The cytoplasmic domains of integrins provide attachment of these extracellular matrix receptors to the cytoskeleton and play a critical role in integrin-mediated signal transduction. In this report we describe the identification, expression, localiza

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::971efbf0333d99b9d99bc9e5f6a4fae1
http://europepmc.org/articles/PMC2120711

A novel phosphoglucomutase-related protein is concentrated in adherens junctions of muscle and nonmuscle cells

Autor: Alexey M. Belkin, Victor E. Koteliansky, David R. Critchley, Matvey E. Lukashev, Kathryn Lilley, Irina V. Klimanskaya

Publikováno v: Journal of Cell Science. 107:159-173

Using five monoclonal antibodies raised against a human uterine smooth muscle extract, we have identified a novel antigen which runs as a closely spaced doublet in SDS-gels. The proteins (60/63 kDa) co-purify, are present in a 1:1 ratio as judged by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::500454b1a81d7a5887693661e383d284
https://doi.org/10.1242/jcs.107.1.159