Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Victor E Shashoua"'
Extracellular Fluid Proteins of Goldfish Brain: Evidence for the Presence of Proteases and Esterases
Autor:
Barton Holmquist, Victor E. Shashoua
Publikováno v:
Journal of Neurochemistry. 47:738-743
Preparations of enriched fractions of extracellular fluid (ECF) proteins from goldfish brain were found to contain protease(s) and esterase(s). The N-substituted furanacryloyl (FA) peptides FA-Phe-Gly-Gly and FA-Phe-OMe were used as model substrates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f168427860d3fec66ceb32016ddbabf
https://doi.org/10.1111/j.1471-4159.1986.tb00674.x
https://doi.org/10.1111/j.1471-4159.1986.tb00674.x
Autor:
Anne Boyer-Boiteau, Victor E Shashoua, Marc Fisher, David S Adams, Fuhai Li, Ann Cornell-Bell
Publikováno v:
Brain Research. 963:214-223
NGF (nerve growth factor) and BDNF (brain-derived neurotrophic factor) are protein molecules (MW 26 and 13.6 kDa, respectively) that are neuroprotective in the middle cerebral artery occlusion (MCAO) rat stroke model. Their mechanism of action involv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b79c7e7f37ce23a9b7755a9a5596660d
https://doi.org/10.1016/s0006-8993(02)04058-1
https://doi.org/10.1016/s0006-8993(02)04058-1
Autor:
Ross J. Baldessarini, Alexander Campbell, Nora S. Kula, Victor E. Shashoua, James G. Flood, Matthews O. Bradley, S. Hemamalini, Nigel L. Webb, Charles S. Swindell
Publikováno v:
Neuropsychopharmacology. 24:55-65
Stable amides of clozapine derived from fatty acids prominent in cerebral tissue might enhance the central activity of clozapine and reduce its exposure to peripheral tissues. Such derivatives might enhance the safety of this unique drug, which is th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e479099988948dcd08c59824400dcd
https://doi.org/10.1016/s0893-133x(00)00173-1
https://doi.org/10.1016/s0893-133x(00)00173-1
Autor:
Victor E. Shashoua, Gary W. Hesse
Publikováno v:
Life Sciences. 58:1347-1357
Fatty acids with varying chain lengths ( 2–22 carbon atoms long ) and degrees of unsaturation (0–6 double bonds) were used to synthesize dopaminergic compounds for a study of the carrier mediated transport of dopamine (DA) to the brain. The most
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f543ef5c15e266fa36403ea5662922
https://doi.org/10.1016/0024-3205(96)00101-4
https://doi.org/10.1016/0024-3205(96)00101-4
Publikováno v:
Journal of Neuroscience Research. 32:239-244
Northern blot, immunoprecipitation, and gel electrophoretic data demonstrate that the mouse neuroblastoma NB2a/d1 cells express ependymin mRNA and synthesize and release into the culture medium a protein with immunoreactivity and electrophoretic mobi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a12d9e6735c2a5c70ad8272608ae134
https://doi.org/10.1002/jnr.490320213
https://doi.org/10.1002/jnr.490320213
Autor:
Victor E. Shashoua
Publikováno v:
Annals of the New York Academy of Sciences. 627:94-114
Ependymin, a glycoprotein of the brain ECF, has been implicated in the neurochemistry of memory and neuronal regeneration. Three behavioral experiments (swimming with a float, avoidance conditioning, and classical conditioning) in the goldfish and on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::036d091c06ce5e10492312fc2ff0e931
https://doi.org/10.1111/j.1749-6632.1991.tb25916.x
https://doi.org/10.1111/j.1749-6632.1991.tb25916.x
Publikováno v:
Journal of Medicinal Chemistry. 33:733-736
1-O-Linolenoyl-2-O-(4-aminobutyryl)-3-O-(4-vinyl-4-aminobutyryl)glycerol (LGV) was synthesized as an example of a prodrug which readily penetrates the blood-brain barrier (brain penetration index 97% +/- 15%) and releases two active substances in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c824c71c02ca90e630cd2d36b614b19c
https://doi.org/10.1021/jm00164a042
https://doi.org/10.1021/jm00164a042
Publikováno v:
Brain research. 1024(1-2)
Neurodegenerative, cardiovascular, and age-related disorders have been attributed to the cellular damage caused by elevated production of reactive oxygen species (ROS) and free radicals (FRs). These cannot be adequately defended by existing levels of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2788ba7aa11cc9f1e23a539363b1a44f
https://pubmed.ncbi.nlm.nih.gov/15451365
https://pubmed.ncbi.nlm.nih.gov/15451365
Publikováno v:
Journal of neuroscience research. 72(3)
Ependymin (EPN) is a goldfish brain neurotrophic factor previously shown to function in a variety of cellular events related to long-term memory formation and neuronal regeneration. CMX-8933, an 8-amino-acid synthetic peptide fragment of EPN, was des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f7995efaa42981fe9728f13988bc22
https://pubmed.ncbi.nlm.nih.gov/12692907
https://pubmed.ncbi.nlm.nih.gov/12692907
Publikováno v:
Neuroscience letters. 312(2)
An 8-amino acid peptide fragment (CMX-8933) of Ependymin, a glycoprotein component of the extracellular fluid and cerebrospinal fluid of goldfish brain, was synthesized and tested for its capacity to activate AP-1 transcription factor in cell culture
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::951ff962658263c10bbc90fe65d7308b
https://pubmed.ncbi.nlm.nih.gov/11595345
https://pubmed.ncbi.nlm.nih.gov/11595345