Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Victor C. Rucker"'
Autor:
Victor C. Rucker, Lily J. Ackerman
Publikováno v:
Science & Education. 18:67-71
Publikováno v:
The Journal of Physical Chemistry B. 108:7490-7494
The fluorescence from the tetramethylrhodamine (TMR) moiety in hairpin polyamide−TMR conjugates is quenched in solution, but restored upon sequence-specific binding to doubled-stranded DNA. This fluorescence amplification when bound to the target D
Publikováno v:
Helvetica Chimica Acta. 86:1839-1851
Antiparallel polyamides containing 1H-pyrrole, 1H-imidazole, and 3-hydroxy-1H-pyrrole amino acids display a preference for minor-groove binding oriented N-C with respect to the 5′-3′ direction of the DNA helix. We find that replacement of a centr
Publikováno v:
Journal of the American Chemical Society. 125:1195-1202
Methods for the fluorescent detection of specific sequences of double strand DNA in homogeneous solution may be useful in the field of human genetics. A series of hairpin polyamides with tetramethyl rhodamine (TMR) attached to an internal pyrrole rin
Autor:
Jason J. Coull, David M. Margolis, Christian Melander, Victor C. Rucker, Peter B. Dervan, Guocheng He
Publikováno v:
Journal of Virology. 76:12349-12354
The host factor LSF represses the human immunodeficiency virus type 1 long terminal repeat (LTR) by mediating recruitment of histone deacetylase. We show that pyrrole-imidazole polyamides targeted to the LTR can specifically block LSF binding both in
Autor:
Karen Havenstrite, Shane M. Sickafoose, Blake A. Simmons, and Amy E. Herr, Renee Shediac, Victor C. Rucker
Publikováno v:
Langmuir : the ACS journal of surfaces and colloids. 21(17)
Reactive ion etching (RIE) was used to pattern antibodies onto the surfaces of polymer substrates. A low pressure, inductively coupled oxygen plasma was used to anisotropically etch 25-30 mum deep features into poly(methyl methacrylate) (PMMA), Zeone
Publikováno v:
Analytical biochemistry. 339(2)
We have developed antibody-based microarray techniques for the multiplexed detection of cholera toxin beta-subunit, diphtheria toxin, anthrax lethal factor and protective antigen, Staphylococcus aureus enterotoxin B, and tetanus toxin C fragment in s
Autor:
Victor C. Rucker, Jason J. Coull, Scott J. Brodie, Loyda Ylisastigui, David M. Margolis, Peter B. Dervan, Ronald J. Bosch, Christian Melander, Donald L. Sodora, Lawrence Corey
Publikováno v:
The Journal of infectious diseases. 190(8)
Background. The persistence of human immunodeficiency virus (HIV) type 1 within resting CD4+ T cells poses a daunting therapeutic challenge. Histone deacetylase (HDAC)-1, a chromatin-remodeling enzyme that can mediate gene silencing, is recruited to
Autor:
Larry D. Byers, Victor C. Rucker
Enzymes greatly enhance the rate of reactions by a variety of physical organic mechanisms. One of the more contentious of these has been desolvation. To get a quantitative assessment of this contribution, we examined acetyl transfer to oxydianions. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65449a79652f860b1a199d78b6e69d0d
https://resolver.caltech.edu/CaltechAUTHORS:20170425-123232383
https://resolver.caltech.edu/CaltechAUTHORS:20170425-123232383
Autor:
Victor C. Rucker, Larry D. Byers
Publikováno v:
Phosphorus, Sulfur, and Silicon and the Related Elements. 147:59-59
The nucleophilic reactivity of the phosphate dianion in aqueous solution is unusually low, relative to that of other nucleophiles of comparable pK4,s. For example, in the reaction with g-nitrophenyl acetate (pNPA), phosphate shows a negative deviatio