Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Victor Adebomi"'
Publikováno v:
Org Lett
The chemo- and site-selective reaction at the particular C─N amide bond among a sea of other amides is a significant and long-standing challenge. Although the use of twisted amides has been demonstrated for modifications of inert C─N amide bonds,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca59238ddfa84d5f0525a05ddc7d1de2
https://doi.org/10.1021/acs.orglett.2c02420
https://doi.org/10.1021/acs.orglett.2c02420
Autor:
Stephen A. Rettie, Katelyn V. Campbell, Asim K. Bera, Alex Kang, Simon Kozlov, Joshmyn De La Cruz, Victor Adebomi, Guangfeng Zhou, Frank DiMaio, Sergey Ovchinnikov, Gaurav Bhardwaj
Publikováno v:
bioRxiv
Deep learning networks offer considerable opportunities for accurate structure prediction and design of biomolecules. While cyclic peptides have gained significant traction as a therapeutic modality, developing deep learning methods for designing suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeffc73c5a5f44f9ac6bae7b19d288fa
https://doi.org/10.1101/2023.02.25.529956
https://doi.org/10.1101/2023.02.25.529956
Publikováno v:
Synlett. 31:1537-1542
The emergence of cyclic peptides as pharmaceuticals has led to an eruption of new methodologies for macrocyclization. However, the cyclization of peptides at high concentrations presents a challenge due to the production of side products like dimers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0daff303f5fab1d706ed758541bdac5
https://doi.org/10.1055/s-0040-1707165
https://doi.org/10.1055/s-0040-1707165
Publikováno v:
Angewandte Chemie. 132:2815-2823
Nitroalkanes react specifically with aldehydes, providing rapid, stable, and chemoselective protein bioconjugation. These nitroalkylated proteins mimic key post-translational modifications (PTMs) of proteins and can be used to understand the role of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::023fe5d71894f4c6489cee7c89693e09
https://doi.org/10.1002/ange.201908593
https://doi.org/10.1002/ange.201908593
Publikováno v:
Tetrahedron. 126:133071
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7d40ac90af5f8efd084f6ae4d2745c1
https://doi.org/10.1016/j.tet.2022.133071
https://doi.org/10.1016/j.tet.2022.133071
Publikováno v:
Organic letters. 23(16)
Here we solve a long-standing challenge of the site-selective modification of secondary amides and present a simple two-step, metal-free approach to selectively modify a particular secondary amide in molecules containing multiple primary and secondar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8662fd6cbcd569cadf37e03eea35ba6c
https://pubmed.ncbi.nlm.nih.gov/34251828
https://pubmed.ncbi.nlm.nih.gov/34251828
Autor:
Monika Raj, Gary E. Martin, Rachel Wills, Ryan D. Cohen, Holland Andrew Hays Chavers, Victor Adebomi
Publikováno v:
Angewandte Chemie International Edition. 58:19073-19080
Here, we report a novel "CyClick" strategy for the macrocyclization of peptides that works in an exclusively intramolecular fashion thereby precluding the formation of dimers and oligomers via intermolecular reactions. The CyClick chemistry is highly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44446e7e9500a00f5ae8fc2364fb4b3e
https://doi.org/10.1002/anie.201911900
https://doi.org/10.1002/anie.201911900
Publikováno v:
Chembiochem : a European journal of chemical biology. 22(1)
Cyclized peptides have seen a rise in popularity in the pharmaceutical industry as drug molecules. As such, new macrocyclization methodologies have become abundant in the last several decades. However, efficient methods of cyclization without the for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d214f1516262c73419e0c6bb8e95ee2
https://pubmed.ncbi.nlm.nih.gov/32794268
https://pubmed.ncbi.nlm.nih.gov/32794268