Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Victor A. Terentiev"'
Autor:
Yan A. Ivanenkov, Alex Zhavoronkov, Renat S. Yamidanov, Ilya A. Osterman, Petr V. Sergiev, Vladimir A. Aladinskiy, Anastasia V. Aladinskaya, Victor A. Terentiev, Mark S. Veselov, Andrey A. Ayginin, Victor G. Kartsev, Dmitry A. Skvortsov, Alexey V. Chemeris, Alexey Kh. Baimiev, Alina A. Sofronova, Alexander S. Malyshev, Gleb I. Filkov, Dmitry S. Bezrukov, Bogdan A. Zagribelnyy, Evgeny O. Putin, Maria M. Puchinina, Olga A. Dontsova
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Many pharmaceutical companies are avoiding the development of novel antibacterials due to a range of rational reasons and the high risk of failure. However, there is an urgent need for novel antibiotics especially against resistant bacterial strains.
Externí odkaz:
https://doaj.org/article/8c16a1d4d0ea467faf6fd76819573bdc
Autor:
Vladimir A. Aladinskiy, Rostislav A Petrov, Yan A. Ivanenkov, Mark S. Veselov, Andrey A Ayginin, Alexey Kh Baimiev, Maria M Puchinina, Marina A Maximova, Anastasia V. Aladinskaya, Dmitry A. Skvortsov, Kseniya Yu Shvetc, Yulia V. Vakhitova, Alina A. Sofronova, Ilya A. Osterman, Andrey Kh Baimiev, Zulfiya R Zileeva, Katerina S Komarova, Dmitry S. Bezrukov, L. F. Zainullina, Victor A Terentiev, Bogdan A Zagribelnyy, Petr V. Sergiev, Alexey E. Machulkin, Renat S. Yamidanov, Olga A. Dontsova
Publikováno v:
Current Drug Discovery Technologies. 17:716-724
Background: The key issue in the development of novel antimicrobials is a rapid expansion of new bacterial strains resistant to current antibiotics. Indeed, World Health Organization has reported that bacteria commonly causing infections in hospitals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95a9cc3c7142a75575f2c9fc022e9cc1
https://doi.org/10.2174/1570163816666190603095521
https://doi.org/10.2174/1570163816666190603095521
Autor:
Rostislav A Petrov, Dmitry A. Skvortsov, Yulia V. Vakhitova, L. F. Zainullina, Andrey A Ayginin, Yan A. Ivanenkov, Marina A Maximova, Mark S. Veselov, Alina A. Sofronova, Petr V. Sergiev, G. I. Filkov, Alexey E. Machulkin, Katerina S Komarova, Anastasia V. Aladinskaya, Renat S. Yamidanov, Victor A Terentiev, Olga A. Dontsova, Alexander S. Malyshev, Alexey Kh Baimiev, Maria M Puchinina, Ilya A. Osterman, Dmitry S. Bezrukov, A. V. Chemeris, Zulfiya R Zileeva, Vladimir A. Aladinskiy
Publikováno v:
Combinatorial Chemistry & High Throughput Screening. 22:346-354
Aim and Objective:Antibiotic resistance is a serious constraint to the development of new effective antibacterials. Therefore, the discovery of the new antibacterials remains one of the main challenges in modern medicinal chemistry. This study was un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::336c3c036716b074c805801cbd19401f
https://doi.org/10.2174/1386207322666190412165316
https://doi.org/10.2174/1386207322666190412165316
Autor:
Andrey Baymiev, Rostislav A Petrov, Svetlana Iu Iarovenko, Vladimir A. Aladinskiy, Renat S. Yamidanov, Alexey E. Machulkin, Yan A. Ivanenkov, Mark S. Veselov, Katerina S Komarova, Olga A. Dontsova, Alexander S. Malyshev, Anastasia V. Aladinskaya, Victor A Terentiev, Andrey A Ayginin, Alina A. Sofronova, Petr V. Sergiev, Dmitry A. Skvortsov, Sergey V. Sadovnikov, Dmitrii A. Lukianov, Ilya A. Osterman, Dmitry S. Bezrukov, R.T. Matniyazov
Publikováno v:
The Journal of Antibiotics. 72:827-833
The present report describes our efforts to identify new structural classes of compounds having promising antibacterial activity using previously published double-reporter system pDualrep2. This semi-automated high-throughput screening (HTS) platform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a36fba2b0d31d2a9e5211cc1d0ef53e
https://doi.org/10.1038/s41429-019-0211-y
https://doi.org/10.1038/s41429-019-0211-y
Autor:
Yan A. Ivanenkov, Alex Zhavoronkov, Mark S. Veselov, Rim Shayakhmetov, Anastasiya V Aladinskaya, Daniil Polykovskiy, Victor A Terentiev, Vladimir A. Aladinskiy, Bogdan A Zagribelnyy, Tao Guo, Artem Zholus, Yury Volkov, Alexander Zhebrak, Lennart H Lee, Li Xing, Lidiya I Minaeva, Richard Soll, Alán Aspuru-Guzik, Alexander Aliper, David Madge, Maksim Kuznetsov, Arip Asadulaev
Publikováno v:
Nature Biotechnology. 37:1038-1040
We have developed a deep generative model, generative tensorial reinforcement learning (GENTRL), for de novo small-molecule design. GENTRL optimizes synthetic feasibility, novelty, and biological activity. We used GENTRL to discover potent inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57935a11c69db73ee57db030f1e4ba3b
https://doi.org/10.1038/s41587-019-0224-x
https://doi.org/10.1038/s41587-019-0224-x
Autor:
A. A. Vladimirova, Ayrat R. Mavzyutov, Yan A. Ivanenkov, Kseniya Yu. Filyaeva, Victor G Kartsev, Valeriya I. Marina, Victor A Terentiev, Renat S. Yamidanov, Olga A. Dontsova, Andrey Baymiev, Julia V. Vakhitova, R.T. Matniyazov, Ilya A. Osterman, Dmitry S. Bezrukov, Alexey Kh. Baymiev, L. F. Zainullina, Zulfia R. Zileeva
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 43:128055
The antibacterial properties of close noscapine analogs have not been previously reported. We used our pDualrep2 double-reporter High Throughput Screening (HTS) platform to identify a series of noscapine derivatives with promising antibacterial activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec22722540a284b8ec7f0a235d6d3016
https://doi.org/10.1016/j.bmcl.2021.128055
https://doi.org/10.1016/j.bmcl.2021.128055
Autor:
Rostislav A Petrov, Marina A Maximova, Yan A. Ivanenkov, Andrey A Ayginin, Zulfiya R Zileeva, Ilya A. Osterman, Dmitry S. Bezrukov, Alexey E. Machulkin, Katerina S Komarova, Victor A Terentiev, Mark S. Veselov, Vladimir A. Aladinskiy, Olga A. Dontsova, Anastasia V. Aladinskaya, Dmitry A. Skvortsov, Yulia V. Vakhitova, Renat S. Yamidanov, Alina A. Sofronova, Petr V. Sergiev, A. V. Chemeris, G. I. Filkov, Svetlana Yu. Maklakova, L. F. Zainullina, Victor G Kartsev, Alexey Kh Baimiev
Publikováno v:
Molecular diversity. 24(1)
A series of 5-oxo-4H-pyrrolo[3,2-b]pyridine derivatives was identified as novel class of highly potent antibacterial agents during an extensive large-scale high-throughput screening (HTS) program utilizing a unique double-reporter system—pDualrep2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59eba89cf136e9ae4cac5e8e9d33cda2
https://pubmed.ncbi.nlm.nih.gov/30949901
https://pubmed.ncbi.nlm.nih.gov/30949901
Autor:
Victor A Terentiev, Renat S. Yamidanov, Olga A. Dontsova, Mark S. Veselov, Alina A. Sofronova, Andrey A Ayginin, Anastasia V. Aladinskaya, Alexey E. Machulkin, Andrey Baymiev, Zulfiya R Zileeva, L. F. Zainullina, A. V. Chemeris, Rostislav A Petrov, Vladimir A. Aladinskiy, Dmitry A. Skvortsov, Marina A Maximova, Yulia V. Vakhitova, Maria M Puchinina, Petr V. Sergiev, Yan A. Ivanenkov, Alexey Kh. Baymiev, Ilya A. Osterman, Dmitry S. Bezrukov, Dmitrii A. Lukianov, Katerina S Komarova
Publikováno v:
Combinatorial chemistryhigh throughput screening. 22(6)
Introduction: A variety of organic compounds has been reported to have antibacterial activity. However, antimicrobial resistance is one of the main problems of current anti-infective therapy, and the development of novel antibacterials is one of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cea141cc0dae11e01a5cd8772c71eb80
https://pubmed.ncbi.nlm.nih.gov/31573876
https://pubmed.ncbi.nlm.nih.gov/31573876