Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Victor A Streltsov"'
Publikováno v:
IUCrJ, Vol 11, Iss 3, Pp 325-346 (2024)
An X-ray absorption spectroscopy (XAS) electrochemical cell was used to collect high-quality XAS measurements of N-truncated Cu:amyloid-β (Cu:Aβ) samples under near-physiological conditions. N-truncated Cu:Aβ peptide complexes contribute to oxidat
Externí odkaz:
https://doaj.org/article/e8c4cc04563b4456be2bdc1ee3d686af
Autor:
Sukanya Luang, Xavier Fernández-Luengo, Alba Nin-Hill, Victor A. Streltsov, Julian G. Schwerdt, Santiago Alonso-Gil, James R. Ketudat Cairns, Stéphanie Pradeau, Sébastien Fort, Jean-Didier Maréchal, Laura Masgrau, Carme Rovira, Maria Hrmova
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Barley β-d-glucan glucohydrolase is a glycoside hydrolase family 3 (GH3) enzyme critical for growth and development. Here the authors carryout mutagenesis, structural analyses and multi-scale molecular dynamics to examine the binding and conformatio
Externí odkaz:
https://doaj.org/article/4f9e72f63f2e475ebb7a7c53d7164632
Autor:
Victor A. Streltsov, Sukanya Luang, Alys Peisley, Joseph N. Varghese, James R. Ketudat Cairns, Sebastien Fort, Marcel Hijnen, Igor Tvaroška, Ana Ardá, Jesús Jiménez-Barbero, Mercedes Alfonso-Prieto, Carme Rovira, Fernanda Mendoza, Laura Tiessler-Sala, José-Emilio Sánchez-Aparicio, Jaime Rodríguez-Guerra, José M. Lluch, Jean-Didier Maréchal, Laura Masgrau, Maria Hrmova
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Enzyme substrates and products often diffuse too rapidly to assess the catalytic implications of these movements. Here, the authors characterise the structural basis of product and substrate diffusion for an exo-hydrolase and discover a substrate-pro
Externí odkaz:
https://doaj.org/article/393023e627f645a0b2087690681cc2f6
Autor:
Soumya Mukherjee, Celine Dubois, Keyla Perez, Shiji Varghese, Ian E. Birchall, Miranda Leckey, Natalia Davydova, Catriona McLean, Rebecca M. Nisbet, Blaine R. Roberts, Qiao‐Xin Li, Colin L. Masters, Victor A. Streltsov
Publikováno v:
Journal of Neurochemistry. 164:529-552
The two hallmarks of Alzheimer's disease (AD) are amyloid-β (Aβ) plaques and neurofibrillary tangles marked by phosphorylated tau. Increasing evidence suggests that aggregating Aβ drives tau accumulation, a process that involves synaptic degenerat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f118ba71b5e2690dc42af79e6bed1c47
https://doi.org/10.1111/jnc.15713
https://doi.org/10.1111/jnc.15713
Autor:
Ruben A. Dilanian, Sophie R. Williams, Andrew V. Martin, Victor A. Streltsov, Harry M. Quiney
Publikováno v:
IUCrJ, Vol 3, Iss 2, Pp 127-138 (2016)
Serial femtosecond X-ray crystallography (SFX) has created new opportunities in the field of structural analysis of protein nanocrystals. The intensity and timescale characteristics of the X-ray free-electron laser sources used in SFX experiments nec
Externí odkaz:
https://doaj.org/article/0b1d46dcb339457699995ff152cef740
Autor:
Victor A Streltsov, Shiji Varghese, Soumya Mukherjee, Liang Jin, Catriona McLean, Blaine R. Roberts, Ian Birchall, Celine Dubois, Colin L. Masters, Qiao-Xin Li, Kevin J Barham, Rebecca M Nisbet, Laura J Vella, Keyla Perez
Publikováno v:
ACS Chemical Neuroscience. 12:3719-3732
Protein citrullination (deimination of arginine residue) is a well-known biomarker of inflammation. Elevated protein citrullination has been shown to colocalize with extracellular amyloid plaques in postmortem AD patient brains. Amyloid-β (Aβ) pept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c14f519fec07d885d802d079208a4e1
https://doi.org/10.1021/acschemneuro.1c00474
https://doi.org/10.1021/acschemneuro.1c00474
Autor:
Christopher T. Chantler, Victor A. Streltsov, Philip A. Ash, Stephen P. Best, Sofia Diaz-Moreno, Shusaku Hayama, Wangzhe Li
Publikováno v:
Journal of Synchrotron Radiation. 28:472-479
The design and performance of an electrochemical cell and solution flow system optimized for the collection of X-ray absorption spectra from solutions of species sensitive to photodamage is described. A combination of 3D CAD and 3D printing technique
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6000cdb9f7025aeae91e7926f900ea72
https://doi.org/10.1107/s1600577520016021
https://doi.org/10.1107/s1600577520016021
Publikováno v:
International Journal of Molecular Sciences, Vol 11, Iss 7, Pp 2759-2769 (2010)
Wild-type and variant crystals of a recombinant enzyme β-d-glucan glucohydrolase from barley (Hordeum vulgare L.) were obtained by macroseeding and cross-seeding with microcrystals obtained from native plant protein. Crystals grew to dimensions of u
Externí odkaz:
https://doaj.org/article/c8284811788d4080a396cc8196dab5b4
Autor:
Timothy M. Ryan, Joanne Caine, Haydyn D.T. Mertens, Nigel Kirby, Julie Nigro, Kerry Breheney, Lynne J. Waddington, Victor A. Streltsov, Cyril Curtain, Colin L. Masters, Blaine R. Roberts
Publikováno v:
PeerJ, Vol 1, p e73 (2013)
Alzheimer’s disease is the leading cause of dementia in the elderly. Pathologically it is characterized by the presence of amyloid plaques and neuronal loss within the brain tissue of affected individuals. It is now widely hypothesised that fibrill
Externí odkaz:
https://doaj.org/article/7b1183117385402f99febb60c89c705d
Autor:
Kirsten F. Howlett, Adrian Cooper, Clinton R. Bruce, Simon T. Bond, Shaun A. Mason, Greg M. Kowalski, Ken Walder, Sean L. McGee, Timothy Connor, Victor A. Streltsov
Publikováno v:
The FASEB Journal. 31:2592-2602
Reciprocal regulation of hepatic glycolysis and gluconeogenesis contributes to systemic metabolic homeostasis. Recent evidence from lower order organisms has found that reversible post-translational modification of glyceraldehyde-3-phosphate dehydrog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7c051b3a07caed8bc86b3c7396dbe28
https://doi.org/10.1096/fj.201601215r
https://doi.org/10.1096/fj.201601215r