The RNA binding protein DND1 is elevated in a subpopulation of pro-spermatogonia and targets chromatin modifiers and translational machinery during late gestation.

Autor: Victor A Ruthig, Talia Hatkevich, Josiah Hardy, Matthew B Friedersdorf, Chloé Mayère, Serge Nef, Jack D Keene, Blanche Capel

Publikováno v: PLoS Genetics, Vol 19, Iss 3, p e1010656 (2023)

DND1 is essential to maintain germ cell identity. Loss of Dnd1 function results in germ cell differentiation to teratomas in some inbred strains of mice or to somatic fates in zebrafish. Using our knock-in mouse line in which a functional fusion prot

Externí odkaz: https://doaj.org/article/a9cb2c0b145e4428bdd7ec37ff64e296

Contributors

Autor: Vimla Aggarwal, T.M. Barber, Christian M. Becker, Karanveer Bhangu, Mats Brännström, Carolyn J. Brown, Richard O. Burney, Antonio Capalbo, Wai-Yee Chan, Andy Chun Hang Chen, Chien-Wen Chen, Ming-Jer Chen, Zi-Jiang Chen, Ya-Ching Chou, Kwong Wai Choy, Hugh J. Clarke, Marcos Cordoba, Pernilla Dahm-Kähler, Mo-Yu Dai, Jessica Garcia de Paredes, Guo-Lian Ding, Zirui Dong, Jin Du, C. Eguizabal, Heather E. Fice, S. Franks, Qing-Qin Gao, Jessica Giordano, Linda C. Giudice, Jordan Gosnell, Ting Guo, Meade Haller, Tristan Hardy, Qilong He, L. Herrera, Ali Honaramooz, Cheng Huang, He-Feng Huang, Ghada Hussein, Sylvie Jaillard, Hai-Ping Jiang, Zi-Ru Jiang, Laura Kasak, Kazuhiro Kawamura, Ali Khatibi, Chaini Konwar, Maris Laan, Guan-Lin Lai, Jonathan LaMarre, Dolores J. Lamb, Yin Lau Lee, Yi-Xuan Lee, Brynn Levy, Xin-Yuan Li, Yao Li, Yu-Fei Li, Jinyue Liao, Ming Liu, Xiaodong Liu, Xin-Mei Liu, Y.M. Dennis Lo, Xinyi Ma, Yun-Yi Ma, M. Martin-Inaraja, Stacey A. Missmer, Kai Kei Miu, Grant Montgomery, N. Montserrat, Cynthia C. Morton, Maria Jose Navarro-Cobos, Robert J. Norman, Marisol O’Neill, Fanghong Ou, Yanli Pang, Maria S. Peñaherrera, Maurizio Poli, Jose M. Polo, Jie Qiao, Yingying Qin, Endah Rahmawati, Nilufer Rahmioglu, Bernard Robaire, Wendy P. Robinson, Alice P. Rogers, Peter A.W. Rogers, I. Romayor, Kristiina Rull, Victor A. Ruthig, Matthew A. Shanahan, Xuan Shao, Andrew H. Sinclair, Leanne Stalker, Kate Stanley, Melissa Stosic, Michael Strug, Hoi-Ching Suen, Jia Ping Tan, Jose M. Teixeira, Nannan Thirumavalavan, Jason C.H. Tsang, Allison Tscherner, Elena J. Tucker, Chii-Ruey Tzeng, Ignatia B. Van den Veyver, Margot van Riel, Joris R. Vermeesch, Liesbeth Vossaert, Wei Wang, Yan-Ling Wang, Zhangting Wang, Ronald Wapner, Nicholas Werry, Jeffrey T. White, Samantha L. Wilson, Jun Wu, Peng Xu, Liying Yan, Zhiqiang Yan, William Shu Biu Yeung, Stephanie C.Y. Yu, Peng Yuan, Victor Yuan, Fan Zhai, Shidou Zhao, Yue Zhao, Boryana Zhelyazkova, Qi Zhou, Krina Zondervan

Publikováno v: Human Reproductive and Prenatal Genetics ISBN: 9780323913805

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e021dcf019339c562794328d6b30c9fc
https://doi.org/10.1016/b978-0-323-91380-5.09990-1

Testicular abnormalities in mice with Y chromosome deficiencies†

Autor: Quinci Salvador, Eglė A. Ortega, Victor A. Ruthig, Torbjoern Nielsen, Yasuhiro Yamauchi, Monika A. Ward, Jonathan M. Riel

Publikováno v: Biology of Reproduction. 96:694-706

We recently investigated mice with Y chromosome gene contribution limited to two, one, or no Y chromosome genes in respect to their ability to produce haploid round spermatids and live offspring following round spermatid injection. Here we explored t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24f6af178d7d4d3337da487ad777fa98
https://doi.org/10.1095/biolreprod.116.144006

The RNA-binding protein DND1 acts sequentially as a negative regulator of pluripotency and a positive regulator of epigenetic modifiers required for germ cell reprogramming

Autor: Victor A. Ruthig, Blanche Capel, Corey Bunce, Steve C. Munger, Jack D. Keene, Matthew B Friedersdorf, Jason A. Garness

Publikováno v: Development

The adult spermatogonial stem cell population arises from pluripotent primordial germ cells (PGCs) that enter the fetal testis around embryonic day 10.5 (E10.5). These cells undergo rapid mitotic proliferation, then enter a prolonged period of cell c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a58ed10ddb75fa259774887d4fea122
https://pubmed.ncbi.nlm.nih.gov/31253634

Macroscopic demonstration of the male urogenital system with evidence of a direct inguinal hernia utilizing room temperature plastination

Autor: Victor A. Ruthig, Scott Lozanoff, Steven Labrash, Monika A. Ward

Publikováno v: Anatomy
Volume: 10, Issue: 3 211-220

The male urogenital system represents a morphologically complex region that arises from a common embryological origin. However, it is typically studied separately as the excretory system is dissected with the posterior wall of the abdomen while the r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0b48a2ac1c7d691939c2007f9811480
https://doi.org/10.2399/ana.16.036