Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Victor A Iglesias"'
Autor:
Amy D Stockwell, Michael C Chang, Anubha Mahajan, William Forrest, Neha Anegondi, Rion K Pendergrass, Suresh Selvaraj, Jens Reeder, Eric Wei, Victor A Iglesias, Natalie M Creps, Laura Macri, Andrea N Neeranjan, Marcel P van der Brug, Suzie J Scales, Mark I McCarthy, Brian L Yaspan
Publikováno v:
PLoS Genetics, Vol 19, Iss 8, p e1010609 (2023)
Diabetic retinopathy (DR) is a common complication of diabetes. Approximately 20% of DR patients have diabetic macular edema (DME) characterized by fluid leakage into the retina. There is a genetic component to DR and DME risk, but few replicable loc
Externí odkaz:
https://doaj.org/article/5e260e67982f45a2b7579ec2725cc7d5
Autor:
Julien Bryois, Daniela Calini, Will Macnair, Lynette Foo, Eduard Urich, Ward Ortmann, Victor Alejandro Iglesias, Suresh Selvaraj, Erik Nutma, Manuel Marzin, Sandra Amor, Anna Williams, Gonçalo Castelo-Branco, Vilas Menon, Philip De Jager, Dheeraj Malhotra
Publikováno v:
Nature Neuroscience, 25(8), 1104-1112. Nature Publishing Group
Bryois, J, Calini, D, Macnair, W, Foo, L, Urich, E, Ortmann, W, Iglesias, V A, Selvaraj, S, Nutma, E, Marzin, M, Amor, S, Williams, A, Castelo-Branco, G, Menon, V, De Jager, P & Malhotra, D 2022, ' Cell-type-specific cis-eQTLs in eight human brain cell types identify novel risk genes for psychiatric and neurological disorders ', Nature Neuroscience, vol. 25, no. 8, pp. 1104-1112 . https://doi.org/10.1038/s41593-022-01128-z
Bryois, J, Calini, D, Macnair, W, Foo, L, Urich, E, Ortmann, W, Iglesias, V A, Selvaraj, S, Nutma, E, Marzin, M, Amor, S, Williams, A, Castelo-Branco, G, Menon, V, De Jager, P & Malhotra, D 2022, ' Cell-type-specific cis-eQTLs in eight human brain cell types identify novel risk genes for psychiatric and neurological disorders ', Nature Neuroscience, vol. 25, no. 8, pp. 1104-1112 . https://doi.org/10.1038/s41593-022-01128-z
To date, most expression quantitative trait loci (eQTL) studies, which investigate how genetic variants contribute to gene expression, have been performed in heterogeneous brain tissues rather than specific cell types. In this study, we performed an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2001352763494c39c5cca9ed221bcc4a
http://www.scopus.com/inward/record.url?scp=85135229265&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85135229265&partnerID=8YFLogxK
Autor:
Christian Czech, Wakana Tang, Teodorica Bugawan, Calvin Mano, Carsten Horn, Victor Alejandro Iglesias, Stefanie Fröhner, Phillip G Zaworski, Sergey Paushkin, Karen Chen, Thomas Kremer
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0139950 (2015)
Spinal muscular atrophy is caused by a functional deletion of SMN1 on Chromosome 5, which leads to a progressive loss of motor function in affected patients. SMA patients have at least one copy of a similar gene, SMN2, which produces functional SMN p
Externí odkaz:
https://doaj.org/article/53d4a02249404fa68e098254b9bca7fb
Autor:
Norcross Roger, Moshe Finel, Nenad Manevski, Victor A. Iglesias, Marius C. Hoener, Dietrich Tuerck, Stephen Fowler, Paul Schmid, Olivia Spleiss, Heidemarie Kletzl
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 352:358-367
RO5263397 [(S)-4-(3-fluoro-2-methyl-phenyl)-4,5-dihydro-oxazol-2-ylamine], a new compound that showed promising results in animal models of schizophrenia, is mainly metabolized in humans by N-glucuronidation. Enzyme studies, using the (then) availabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8172f13f9cad04a04e634c848f42a827
https://doi.org/10.1124/jpet.114.220194
https://doi.org/10.1124/jpet.114.220194
Autor:
Wakana Tang, Calvin Mano, Teodorica L. Bugawan, Sergey Paushkin, Victor A. Iglesias, Carsten Horn, Stefanie Fröhner, Karen S. Chen, Phillip G. Zaworski, Thomas Kremer, Christian Czech
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0139950 (2015)
PLoS ONE
PLoS ONE
Spinal muscular atrophy is caused by a functional deletion of SMN1 on Chromosome 5, which leads to a progressive loss of motor function in affected patients. SMA patients have at least one copy of a similar gene, SMN2, which produces functional SMN p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c18119133b07246deb2d8c92716e47b
http://europepmc.org/articles/PMC4607439?pdf=render
http://europepmc.org/articles/PMC4607439?pdf=render
Autor:
Frederick Meins, Sabrina A. Leuenberger, Patrice Crete, Victor Alejandro Iglesias, Ulrich Gerhard Klahre
Publikováno v:
Proceedings of the National Academy of Sciences. 99:11981-11986
Posttranscriptional gene silencing (PTGS) in transgenic plants is an epigenetic form of RNA degradation related to PTGS and RNA interference (RNAi) in fungi and animals. Evidence suggests that transgene loci and RNA viruses can generate double-strand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8310539e4ba96989dcb2ae34074303b4
https://doi.org/10.1073/pnas.182204199
https://doi.org/10.1073/pnas.182204199
Autor:
Gregor L. Bucher, Manfred Heinlein, Victor Alejandro Iglesias, Frederick Meins, Corina Tarina, Francesco Di Serio
Publikováno v:
The Plant Journal. 28:361-369
Mutant tobacco plants deficient for class I beta-1,3-glucanase (GLU I) are decreased in their susceptibility to virus infection. This is correlated with delayed virus spread, a reduction in the size exclusion limit of plasmodesmata and increased cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16d4b134f76dc64502a040271d9bce1f
https://doi.org/10.1046/j.1365-313x.2001.01181.x
https://doi.org/10.1046/j.1365-313x.2001.01181.x
Autor:
Hauke Holtorf, Hanspeter Schöb, Frederick Meins, Sjoerd van Eeden, Sabrina A. Leuenberger, Patrice Crete, Vivian Suarez, Victor A. Iglesias
Publikováno v:
The Plant Journal. 28:493-501
Sense and antisense tobacco chitinase (CHN) transgenes, Luciferase-CHN transcriptional fusions, and promoterless CHN cDNAs were introduced biolistically into CHN transformants of tobacco that never exhibit spontaneous gene silencing. All of the const
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d436a4d94d4a2b210206f3ce1c8959b1
https://doi.org/10.1046/j.1365-313x.2001.01171.x
https://doi.org/10.1046/j.1365-313x.2001.01171.x
Autor:
Frederick Meins, Victor A. Iglesias
Publikováno v:
The Plant Journal. 21:157-166
Susceptibility to virus infection is decreased in a class I beta-1,3-glucanase (GLU I)-deficient mutant (TAG4.4) of tobacco generated by antisense transformation. TAG4.4 exhibited delayed intercellular trafficking via plasmodesmata of a tobamovirus (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f86e05a5a2030687a4295201f4145b3
https://doi.org/10.1046/j.1365-313x.2000.00658.x
https://doi.org/10.1046/j.1365-313x.2000.00658.x
Autor:
Steven Spiker, Young-Doo Park, István Papp, Antonius J. M. Matzke, Susan Michalowski, Marjori Matzke, Victor A. Iglesias, Eduardo A. Moscone
Publikováno v:
The Plant Journal. 10:469-478
This paper describes molecular and cytogenetic evidence for the stability of a transgene locus that is present on the triplicated chromosome in an aneuploid tobacco line. This instability was manifested in several ways in trisomics including a major
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7deb04dff9abc79ab0d0b11049ce0640
https://doi.org/10.1046/j.1365-313x.1996.10030469.x
https://doi.org/10.1046/j.1365-313x.1996.10030469.x