Výsledky vyhledávání - "Victor, Zdorichenko"

Escaping from Flatland: [2 + 2] Photocycloaddition; Conformationally Constrained sp3-rich Scaffolds for Lead Generation

Autor: Brian Cox, Luke D. Elliott, Kevin I. Booker-Milburn, Victor Zdorichenko, Michael Robertson-Ralph

Publikováno v: ACS Medicinal Chemistry Letters. 10:1512-1517

Pressure on researchers to deliver new medicines to the patient continues to grow. Attrition rates in the research and development process present a significant challenge to the viability of the current model of drug discovery. Analysis shows that in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d4ef66ce3f0965e8a9d7e04b2f3384b
https://doi.org/10.1021/acsmedchemlett.9b00409

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Structural and Electronic Control of the Bidentate 1-(2-pyridyl)benzotriazole Ligand in Copper Chemistry with Application to Catalysis in the A

Autor: Stavroula I, Sampani, Victor, Zdorichenko, Jack, Devonport, Gioia, Rossini, Matthew C, Leech, Kevin, Lam, Brian, Cox, Alaa, Abdul-Sada, Alfredo, Vargas, George E, Kostakis

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany). 27(13)

The hybrid bidentate 1-(2-pyridyl)benzotriazole (pyb) ligand was introduced into 3d transition metal catalysis. Specifically, [Cu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::25470edf750696c23b775b3ea5cd936e
https://pubmed.ncbi.nlm.nih.gov/33296102

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Escaping from Flatland: Antimalarial Activity of sp

Autor: Brian, Cox, James, Duffy, Victor, Zdorichenko, Corentin, Bellanger, Jessica, Hurcum, Benoît, Laleu, Kevin I, Booker-Milburn, Luke D, Elliott, Michael, Robertson-Ralph, Christopher J, Swain, Stephen J, Bishop, Irene, Hallyburton, Mark, Anderson

Publikováno v: ACS Med Chem Lett

[Image: see text] We utilized synthetic photochemistry to generate novel sp(3)-rich scaffolds and report the design, synthesis, and biological testing of a diverse series of amides based on the 1-(amino-methyl)-2-benzyl-2-aza-bicyclo[2.1.1]hexane sca

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https://pubmed.ncbi.nlm.nih.gov/33335673

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'Dial Up and Lock In': Asymmetric Organo-Brønsted Acid Catalysis Incorporating Stable Isotopes

Autor: Sean P. Bew, Dominika U. Bachera, Simon J. Coles, Sean M. Thurston, Glyn D. Hiatt-Gipson, Paolo Pesce, Victor Zdorichenko, Mateusz Pitak

Publikováno v: Chem. 1:921-945

An operationally simple organo-Brønsted-acid-catalyzed asymmetric and regioselective “dial up and lock in” of one or more stable isotopes into organic compounds is unknown. Here, we describe a newly designed, chemically versatile protocol mediat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::566d1fe2415f83502b7e9e328afd1d4c
https://doi.org/10.1016/j.chempr.2016.11.008

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Shedding light on the use of Cu(ii)-salen complexes in the A

Autor: Stavroula I, Sampani, Victor, Zdorichenko, Marianna, Danopoulou, Matthew C, Leech, Kevin, Lam, Alaa, Abdul-Sada, Brian, Cox, Graham J, Tizzard, Simon J, Coles, Athanassios, Tsipis, George E, Kostakis

Publikováno v: Dalton transactions (Cambridge, England : 2003). 49(2)

One Cu(ii) complex, {Cu(ii)L} (1S), has been synthesised, in two high yielding steps under ambient conditions, and characterised by single-crystal X-Ray diffraction (SXRD), IR, UV-Vis, circular dichroism (CD), elemental analysis, thermogravimetric an

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https://pubmed.ncbi.nlm.nih.gov/31750481

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Shedding light on the use of Cu(II)-salen complexes in the A3 coupling reaction

Autor: George E. Kostakis, Athanassios C. Tsipis, Victor Zdorichenko, Brian Cox, Graham J. Tizzard, Simon J. Coles, Matthew C. Leech, Marianna Danopoulou, Stavroula I. Sampani, Kevin Lam, Alaa Abdul-Sada

One Cu(II) complex, {Cu(II)L} (1S), has been synthesised, in two high yielding steps under ambient conditions, and characterised by single-crystal X-Ray diffraction (SXRD), IR, UV-Vis, circular dichroism (CD), elemental analysis, thermogravimetric an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bc2341c40235d9606a62ceebb3996bb
https://eprints.soton.ac.uk/436193/

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Escaping from Flatland: [2 + 2] Photocycloaddition; Conformationally Constrained sp

Autor: Brian, Cox, Kevin I, Booker-Milburn, Luke D, Elliott, Michael, Robertson-Ralph, Victor, Zdorichenko

Publikováno v: ACS Med Chem Lett

[Image: see text] Pressure on researchers to deliver new medicines to the patient continues to grow. Attrition rates in the research and development process present a significant challenge to the viability of the current model of drug discovery. Anal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8b9111d6a5b4bb6e512f10e9e692a282
https://pubmed.ncbi.nlm.nih.gov/31749903

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The Synthesis of Waltherione F and Its Analogues with Modifications at the 2- and 3-Positions as Potential Antitrypanosomal Agents

Autor: Romain Paumier, Mark Roe, Brian Cox, Thomas Whitmarsh-Everiss, Victor Zdorichenko

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany). 25(5)

Chagas disease also know as American Trypanosomiasis (AT) is a tropical parasitic disease endemic in South America, is caused by Trypanosoma cruzi, which is transmitted by the blood-sucking insect vectors called triatomine bugs. Quinoline alkaloids f

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https://pubmed.ncbi.nlm.nih.gov/30398681

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