Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Victor, Yip"'
Autor:
Neelie Zacharias, Vladimir N. Podust, Kimberly K. Kajihara, Douglas Leipold, Geoffrey Del Rosario, Desiree Thayer, Emily Dong, Maciej Paluch, David Fischer, Kai Zheng, Corinna Lei, Jintang He, Carl Ng, Dian Su, Luna Liu, Shabkhaiz Masih, William Sawyer, Jeff Tinianow, Jan Marik, Victor Yip, Guangmin Li, Josefa Chuh, J. Hiroshi Morisaki, Summer Park, Bing Zheng, Hilda Hernandez-Barry, Kelly M. Loyet, Min Xu, Katherine R. Kozak, Gail Lewis Phillips, Ben-Quan Shen, Cong Wu, Keyang Xu, Shang-Fan Yu, Amrita Kamath, Rebecca K. Rowntree, Dorothea Reilly, Thomas Pillow, Andrew Polson, Volker Schellenberger, Wouter L. W. Hazenbos, Jack Sadowsky
Publikováno v:
Chemical Science. 13:3147-3160
The antibody-drug conjugate (ADC) is a well-validated modality for the cell-specific delivery of small molecules with impact expanding rapidly beyond their originally-intended purpose of treating cancer. However, antibody-mediated delivery (AMD) rema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01bce602efd8f14a1021c22dad6d1512
https://doi.org/10.1039/d1sc05243h
https://doi.org/10.1039/d1sc05243h
Autor:
Victor Yip, Gillie Roth, Elizabeth Torres, Sara Wichner, Craig Blanchette, Amrita Kamath, Ben-Quan Shen
Publikováno v:
Cancer Research. 83:LB242-LB242
Messenger RNA (mRNA) has emerged as a new class of therapeutic agent delivered by a carrier lipoplex (LPX) to elicit an immune-response for treating various diseases, including cancers. However, the PK and tissue distribution of the components is not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16abcc2aca57b62ab921d5d561438b85
https://doi.org/10.1158/1538-7445.am2023-lb242
https://doi.org/10.1158/1538-7445.am2023-lb242
Autor:
Ben-Quan Shen, Shab Masih, Brandon Latifi, Isabel Figueroa, Carl Ng, Doug Leipold, Victor Yip, Amrita V. Kamath
Publikováno v:
Drug Metabolism and Disposition. 48:1247-1256
Anti-Ly6E-seco-cyclopropabenzindol-4-one dimer antibody-drug conjugate (ADC) has been reported to form an adduct with α1-microglobulin (A1M) in animal plasma, but with unknown impact on ADC PK and tissue distribution. In this study, we compared the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::945bc3da68bd20d4c91007d4f9bab16e
https://doi.org/10.1124/dmd.120.000145
https://doi.org/10.1124/dmd.120.000145
Autor:
Victor Yip, Shuguang Ma, M. Violet Lee, S. Cyrus Khojasteh, Amrita V. Kamath, Hao Cai, Nina Ljumanovic, Sylvia C. Wong, Ola Saad, Ben-Quan Shen
Publikováno v:
Drug Metabolism and Disposition. 48:1161-1168
Invasive Staphylococcus aureus infection is a leading cause of infectious disease-related deaths because S. aureus survives within host phagocytic cells, from which the bacteria are not adequately eliminated using current antibiotic treatments. Anti-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2622584ef5f0b5981e5f4f14174fc0b
https://doi.org/10.1124/dmd.120.000092
https://doi.org/10.1124/dmd.120.000092
Autor:
Victor Yip, Eugene C. Chen, T. Noelle Lombana, Daniel D. Bravo, Sharon Viajar, Sophia Lee, C. Andrew Boswell, Wilson Phung, Marissa L. Matsumoto, Jianyong Wang, Avinash Gill, Christoph Spiess, Farzam Farahi, Julie A. Zorn, Wendy Sandoval, Sharmila Rajan, Alberto Estevez, Danielle Mandikian, Claudio Ciferri
Publikováno v:
mAbs
IgA antibodies have broad potential as a novel therapeutic platform based on their superior receptor-mediated cytotoxic activity, potent neutralization of pathogens, and ability to transcytose across mucosal barriers via polymeric immunoglobulin rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f0d052bb4c77f518c781fd12efc8c3e
http://europepmc.org/articles/PMC6748581
http://europepmc.org/articles/PMC6748581
Autor:
Volker Schellenberger, David Fischer, Bing Zheng, Thomas H. Pillow, Amrita V. Kamath, Carl Ng, Jan Marik, Corinna Lei, Dorothea Reilly, Shabkhaiz Masih, Kelly M. Loyet, Vladimir N. Podust, Kimberly Kajihara, Maciej Paluch, Andrew Polson, Gail Dianne Phillips, Summer Park, Luna Liu, Morisaki John Hiroshi, Kai Zheng, Guangmin Li, Dian Su, Douglas D. Leipold, Josefa Chuh, Victor Yip, Emily Dong, Shang-Fan Yu, Wouter L. W. Hazenbos, Jack Sadowsky, Geoffrey Del Rosario, Rebecca K. Rowntree, Jeff N. Tinianow, Neelie Zacharias, Min Xu, William S. Sawyer, Katherine R. Kozak, Hilda Hernandez-Barry, Jintang He, Cong Wu, Keyang Xu, Ben-Quan Shen
Antibody-drug conjugates (ADCs) enable cell-specific delivery of small molecules and are validated anti-cancer therapeutics. One factor limiting ADC advancement and broader application is the drug-to-antibody ratio (DAR), which dictates the number of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7d05e7d54cc2ba403b546592bdee064
https://doi.org/10.21203/rs.3.rs-356231/v1
https://doi.org/10.21203/rs.3.rs-356231/v1
Publikováno v:
Journal of Clinical Medicine
Polatuzumab vedotin (or POLIVY®), an antibody–drug conjugate (ADC) composed of a polatuzumab monoclonal antibody conjugated to monomethyl auristatin E (MMAE) via a cleavable dipeptide linker, has been approved by the United States Food and Drug Ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d80020082e1c4f35944efc4752eeed69
https://pubmed.ncbi.nlm.nih.gov/33806916
https://pubmed.ncbi.nlm.nih.gov/33806916
Autor:
Victor, Yip, Isabel, Figueroa, Brandon, Latifi, Shab, Masih, Carl, Ng, Doug, Leipold, Amrita, Kamath, Ben-Quan, Shen
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 48(12)
Anti-Ly6E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2de2d3505eb45e04d58c7ff7b078641c
https://pubmed.ncbi.nlm.nih.gov/33020064
https://pubmed.ncbi.nlm.nih.gov/33020064
Autor:
Hao, Cai, Victor, Yip, M Violet, Lee, Sylvia, Wong, Ola, Saad, Shuguang, Ma, Nina, Ljumanovic, S Cyrus, Khojasteh, Amrita V, Kamath, Ben-Quan, Shen
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 48(11)
Invasive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::da188c45a63ad79fcdaabd6240377711
https://pubmed.ncbi.nlm.nih.gov/32839277
https://pubmed.ncbi.nlm.nih.gov/32839277
Autor:
Melissa Schutten, Brandon Latifi, Ola Saad, Steven T Laing, Shabkhaiz Masih, Jintang He, Isabel Figueroa, Katherine R. Kozak, Douglas D. Leipold, Randall C. Dere, M. Violet Lee, Brian R. Vuillemenot, Andrew Polson, Keyang Xu, Ben-Quan Shen, Montserrat Carrasco-Triguero, Luna Liu, Dian Su, Victor Yip, Bing Zheng, Amrita V. Kamath
Publikováno v:
mAbs
Few treatment options are available for acute myeloid leukemia (AML) patients. DCLL9718A is an antibody-drug conjugate that targets C-type lectin-like molecule-1 (CLL-1). This receptor is prevalent on monocytes, neutrophils, and AML blast cells, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88bf3a1e3a6f99e410d6d7cec20c06c3
https://doi.org/10.1080/19420862.2018.1517565
https://doi.org/10.1080/19420862.2018.1517565