Combinatorial batching of DNA for ultralow-cost detection of pathogenic variants

Autor: Ulrik Kristoffer Stoltze, Christian Munch Hagen, Thomas van Overeem Hansen, Anna Byrjalsen, Anne-Marie Gerdes, Victor Yakimov, Simon Rasmussen, Marie Bækvad-Hansen, David Michael Hougaard, Kjeld Schmiegelow, Henrik Hjalgrim, Karin Wadt, Jonas Bybjerg-Grauholm

Publikováno v: Genome Medicine, Vol 15, Iss 1, Pp 1-12 (2023)

Abstract Background Next-generation sequencing (NGS) based population screening holds great promise for disease prevention and earlier diagnosis, but the costs associated with screening millions of humans remain prohibitive. New methods for populatio

Externí odkaz: https://doaj.org/article/324c1cafcb904cdb8f21fd764f4b0800

Genetic regulation of spermine oxidase activity and cancer risk: a Mendelian randomization study

Autor: João Fadista, Victor Yakimov, Urmo Võsa, Christine S. Hansen, Silva Kasela, Line Skotte, Frank Geller, Julie Courraud, Tõnu Esko, Viktorija Kukuškina, Alfonso Buil, Mads Melbye, Thomas M. Werge, David M. Hougaard, Lili Milani, Jonas Bybjerg-Grauholm, Arieh S. Cohen, Bjarke Feenstra

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)

Abstract Spermine oxidase (SMOX) catalyzes the oxidation of spermine to spermidine. Observational studies have reported SMOX as a source of reactive oxygen species associated with cancer, implying that inhibition of SMOX could be a target for chemopr

Externí odkaz: https://doaj.org/article/064053270d5b471ba5be3613d0db5c34

RNA Sequencing of Trigeminal Ganglia in Rattus Norvegicus after Glyceryl Trinitrate Infusion with Relevance to Migraine.

Autor: Sara Hougaard Pedersen, Lasse Maretty, Roshni Ramachandran, Jonas Andreas Sibbesen, Victor Yakimov, Rikke Elgaard-Christensen, Thomas Folkmann Hansen, Anders Krogh, Jes Olesen, Inger Jansen-Olesen

Publikováno v: PLoS ONE, Vol 11, Iss 5, p e0155039 (2016)

INTRODUCTION:Infusion of glyceryl trinitrate (GTN), a donor of nitric oxide, induces immediate headache in humans that in migraineurs is followed by a delayed migraine attack. In order to achieve increased knowledge of mechanisms activated during GTN

Externí odkaz: https://doaj.org/article/37c178c08cc246fd929a7774a33625de

Genetic regulation of spermine oxidase activity and cancer risk: a Mendelian randomization study

Autor: Line Skotte, Victor Yakimov, Urmo Võsa, Tõnu Esko, Frank Geller, Bjarke Feenstra, Silva Kasela, Julie Courraud, Lili Milani, Arieh S. Cohen, Thomas Werge, Viktorija Kukuškina, David M. Hougaard, João Fadista, Christine Søholm Hansen, Mads Melbye, Jonas Bybjerg-Grauholm, Alfonso Buil

Publikováno v: Scientific Reports
Fadista, J, Yakimov, V, Võsa, U, Hansen, C S, Kasela, S, Skotte, L, Geller, F, Courraud, J, Esko, T, Kukuškina, V, Buil, A, Melbye, M, Werge, T M, Hougaard, D M, Milani, L, Bybjerg-Grauholm, J, Cohen, A S & Feenstra, B 2021, ' Genetic regulation of spermine oxidase activity and cancer risk : a Mendelian randomization study ', Scientific Reports, vol. 11, 17463 . https://doi.org/10.1038/s41598-021-97069-x
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)

Spermine oxidase (SMOX) catalyzes the oxidation of spermine to spermidine. Observational studies have reported SMOX as a source of reactive oxygen species associated with cancer, implying that inhibition of SMOX could be a target for chemoprevention.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43cd8035d310c681897f762594cb82b3
http://europepmc.org/articles/PMC8408253

Study of correlation between the NAT2 phenotype and genotype status among Greenlandic Inuit

Autor: Emilie, Birch Kristensen, Victor, Yakimov, Karen, Bjorn-Mortensen, Bolette, Soborg, Anders, Koch, Mikael, Andersson, Kasper, Birch Kristensen, Sascha Wilk, Michelsen, Line, Skotte, Anne, Ahrendt Bjerregaard, Meinolf, Blaszkewicz, Klaus, Golka, Jan G, Hengstler, Bjarke, Feenstra, Mads, Melbye, Frank, Geller

Publikováno v: EXCLI journal, 17:1043-1053
Kristensen, E B, Yakimov, V, Bjørn-Mortensen, K, Soborg, B, Koch, A, Andersson, M, Kristensen, K B, Michelsen, S W, Skotte, L, Bjerregaard, A A, Blaszkewicz, M, Golka, K, Hengstler, J G, Feenstra, B, Melbye, M & Geller, F 2018, ' Study of correlation between the NAT2 phenotype and genotype status among greenlandic inuit ', EXCLI Journal, vol. 17, pp. 1043-1053 . < https://www.excli.de/index.php/excli/article/view/660 >
EXCLI Journal

N-acetyltransferase 2 (NAT2) is the main enzyme metabolizing isoniazid and genotype-based treatment has been studied for years without becoming common practice. To investigate whether genotype-based isoniazid treatment is feasible in Greenland, we se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a83dd477f9681bfc5020ed7f0fbe80b1
https://www.excli.de/index.php/excli/article/view/660/1865