A phase IIa active-comparator-controlled study to evaluate the efficacy and safety of efinopegdutide in patients with non-alcoholic fatty liver disease

Autor: Bruzone, Santiago Oscar, Coronel, Maria Jimena, Gruz, Fernando M., MacKinnon, Ignacio, George, Jacob, Muller, Kate, Lee, Samuel S., Caussy, Cyrielle, Petit, Jean Michel, Ari, Ziv Ben, Braun, Marius, Katchman, Helena, Lurie, Yoav, Veitsman, Ella, Zuckerman, Eli, Aghemo, Alessio, Basili, Stenfania, Fracanzani, Anna Ludovica, Pietrangelo, Antonello, Sacerdoti, David, Rubio Arce, Jose Francisco, de Guevara Cetina, Alma Laura Ladron, Chavez-Tapia, Norberto Carlos, Reyes, Eira Cerda, Pinzon Te, Lourdes Lol-Be, Baker, John R., Ngu, Jeffrey, Orr, David, Janczewska, Ewa, Matusik, Pawel, Stanislaw Sadurski, Maciej Murawski, Akinina, Anna Valerievna, Alpenidze, Diana Nodarievna, Bogomolov, Pavel, Ermakova, Polina Yurievna, Golovach, Albina V., Kim, Sang Gyune, Lee, Jin-Woo, Paik, Yong Han, Park, Jun Yong, Yeon, Jong Eun, Blasco, Victor Vargas, Madueno, Francisco Jose Tinahones, Panero, Jose Luis Calleja, Perez, Esther Molina, Romero-Gómez, Manuel, Cheng, Pin-Nan, Jeng, Wen-Juei, Liu, Chun-Jen, Akyuz, Filiz, Balaban, Hatice Yasemin, Basaranoglu, Metin, Demir, Tevfik, Idilman, Ramazan, Karakan, Tarkan, Gyrina, Olga, Kolesnikova, Olena Vadimivna, Pyvovar, Sergiy M., Oliinyk, Oleksandr, Skrypnyk, Igor, Bassan, Isaac, Bowman, William Kelly, Denham, Douglas Scott, Ghalib, Reem, Lawitz, Eric J., Lucas, Kathryn Jean, Mohseni, Rizwana H., Sanchez, William Eduardo, Vierling, John Moore, Lawitz, Eric, Shankar, R. Ravi, Chaudhri, Eirum, Liu, Jie, Lam, Raymond L.H., Kaufman, Keith D., Engel, Samuel S.

Publikováno v: In Journal of Hepatology October 2023 79(4):888-897

MELD 3.0 adequately predicts mortality and renal replacement therapy requirements in patients with alcohol-associated hepatitis

Autor: Luis Antonio Díaz, Eduardo Fuentes-López, Gustavo Ayares, Francisco Idalsoaga, Jorge Arnold, María Ayala Valverde, Diego Perez, Jaime Gómez, Rodrigo Escarate, Alejandro Villalón, Carolina A. Ramírez, Maria Hernandez-Tejero, Wei Zhang, Steve Qian, Douglas A. Simonetto, Joseph C. Ahn, Seth Buryska, Winston Dunn, Heer Mehta, Rohit Agrawal, Joaquín Cabezas, Inés García-Carrera, Berta Cuyàs, Maria Poca, German Soriano, Shiv K. Sarin, Rakhi Maiwall, Prasun K. Jalal, Saba Abdulsada, Fátima Higuera-de-la-Tijera, Anand V. Kulkarni, P. Nagaraja Rao, Patricia Guerra Salazar, Lubomir Skladaný, Natália Bystrianska, Ana Clemente-Sanchez, Clara Villaseca-Gómez, Tehseen Haider, Kristina R. Chacko, Gustavo A. Romero, Florencia D. Pollarsky, Juan Carlos Restrepo, Susana Castro-Sanchez, Luis G. Toro, Pamela Yaquich, Manuel Mendizabal, Maria Laura Garrido, Sebastián Marciano, Melisa Dirchwolf, Victor Vargas, César Jiménez, Alexandre Louvet, Guadalupe García-Tsao, Juan Pablo Roblero, Juan G. Abraldes, Vijay H. Shah, Patrick S. Kamath, Marco Arrese, Ashwani K. Singal, Ramon Bataller, Juan Pablo Arab

Publikováno v: JHEP Reports, Vol 5, Iss 8, Pp 100727- (2023)

Background & Aims: Model for End-Stage Liver Disease (MELD) score better predicts mortality in alcohol-associated hepatitis (AH) but could underestimate severity in women and malnourished patients. Using a global cohort, we assessed the ability of th

Externí odkaz: https://doaj.org/article/497553cb7c884b90bbd7340ddb54ae9c

Treatment With Simvastatin and Rifaximin Restores the Plasma Metabolomic Profile in Patients With Decompensated Cirrhosis

Autor: Elisa Pose, Elsa Solà, Juan J. Lozano, Adrià Juanola, Julia Sidorova, Giacomo Zaccherini, Koos deWit, Frank Uschner, Marta Tonon, Konstantin Kazankov, Cesar Jiménez, Daniela Campion, Laura Napoleone, Ann T. Ma, Marta Carol, Manuel Morales‐Ruiz, Carlo Alessandria, Ulrich Beuers, Paolo Caraceni, Claire Francoz, François Durand, Rajeshwar P. Mookerjee, Jonel Trebicka, Victor Vargas, Salvatore Piano, Hugh Watson, Juan G. Abraldes, Patrick S. Kamath, Mark M. Davis, Pere Ginès, for the investigators of the LIVERHOPE Consortium

Publikováno v: Hepatology Communications, Vol 6, Iss 5, Pp 1100-1112 (2022)

Patients with decompensated cirrhosis, particularly those with acute‐on‐chronic liver failure (ACLF), show profound alterations in plasma metabolomics. The aim of this study was to investigate the effect of treatment with simvastatin and rifaximi

Externí odkaz: https://doaj.org/article/ef91c857b6d7462f9f2e68c608047196

Cerebral Cryptococcosis Associated with CD4+ T-lymphocytopenia in Non-HIV Patients after SARS-CoV-2 Infection: Case Series in a Specialized Institute in Lima, Peru

Autor: Juana M. Huamani-Córdova, Miguel Hueda-Zavaleta, Victor Vargas-Bellina, Lourdes Simbron-Ribbeck, Katty del Rosario Chong-Chinchay, Juan Carlos Gómez de la Torre, Vicente A. Benítes-Zapata

Publikováno v: Tropical Medicine and Infectious Disease, Vol 8, Iss 3, p 182 (2023)

Cases of cryptococcosis have been reported in patients with COVID-19. The majority are in patients with severe symptoms or who received immunosuppressants. However, there is still no clear association between COVID-19 and cryptococcosis. We report ei

Externí odkaz: https://doaj.org/article/51b9c88837684e2392b9a22f30f91c44

A phase II study of human allogeneic liver-derived progenitor cell therapy for acute-on-chronic liver failure and acute decompensation

Autor: Frederik Nevens, Thierry Gustot, Pierre-François Laterre, Luc L. Lasser, Lyudmil E. Haralampiev, Victor Vargas, Desislava Lyubomirova, Agustin Albillos, Mustapha Najimi, Sébastien Michel, Ivaylo Stoykov, Noelia Gordillo, Yelena Vainilovich, Virginie Barthel, Nathalie Clerget-Chossat, Etienne M. Sokal

Publikováno v: JHEP Reports, Vol 3, Iss 4, Pp 100291- (2021)

Background & Aims: Human allogeneic liver-derived progenitor cells (HALPC, HepaStem®; Promethera Biosciences, Mont-Saint-Guibert, Belgium) are an advanced therapy medicinal product that could potentially alleviate systemic inflammation and ameliorat

Externí odkaz: https://doaj.org/article/87165a53850a4e95821f7ce0ed7fdee3