Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Victor, Pau"'
Autor:
Monica Bubenik, Pavel Mader, Philippe Mochirian, Fréderic Vallée, Jillian Clark, Jean-François Truchon, Alexander L. Perryman, Victor Pau, Igor Kurinov, Karl E. Zahn, Marie-Eve Leclaire, Robert Papp, Marie-Claude Mathieu, Martine Hamel, Nicole M. Duffy, Claude Godbout, Matias Casas-Selves, Jean-Pierre Falgueyret, Prasamit S. Baruah, Olivier Nicolas, Rino Stocco, Hugo Poirier, Giovanni Martino, Alexanne Bonneau Fortin, Anne Roulston, Amandine Chefson, Stéphane Dorich, Miguel St-Onge, Purvish Patel, Charles Pellerin, Stéphane Ciblat, Thomas Pinter, Francis Barabé, Majida El Bakkouri, Paranjay Parikh, Christian Gervais, Agnel Sfeir, Yael Mamane, Stephen J. Morris, W. Cameron Black, Frank Sicheri, Michel Gallant
Publikováno v:
Journal of Medicinal Chemistry. 65:13198-13215
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::947c93bf7b6803db8ed4beb935e92af5
https://doi.org/10.1021/acs.jmedchem.2c00998
https://doi.org/10.1021/acs.jmedchem.2c00998
Autor:
Chetan K. Chana, Pierre Maisonneuve, Ganna Posternak, Nicolas G.A. Grinberg, Juline Poirson, Samara M. Ona, Derek F. Ceccarelli, Pavel Mader, Daniel J. St-Cyr, Victor Pau, Igor Kurinov, Xiaojing Tang, Dongjing Deng, Weiren Cui, Wenji Su, Letian Kuai, Richard Soll, Mike Tyers, Hannes L. Röst, Robert A. Batey, Mikko Taipale, Anne-Claude Gingras, Frank Sicheri
Publikováno v:
Journal of Medicinal Chemistry. 65:12725-12746
Targeted protein degradation (TPD) strategies exploit bivalent small molecules to bridge substrate proteins to an E3 ubiquitin ligase to induce substrate degradation. Few E3s have been explored as degradation effectors due to a dearth of E3-binding s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9bd44e2ad315c9a8487c6d1e86a88a
https://doi.org/10.1021/acs.jmedchem.2c00509
https://doi.org/10.1021/acs.jmedchem.2c00509
Autor:
Monica, Bubenik, Pavel, Mader, Philippe, Mochirian, Fréderic, Vallée, Jillian, Clark, Jean-François, Truchon, Alexander L, Perryman, Victor, Pau, Igor, Kurinov, Karl E, Zahn, Marie-Eve, Leclaire, Robert, Papp, Marie-Claude, Mathieu, Martine, Hamel, Nicole M, Duffy, Claude, Godbout, Matias, Casas-Selves, Jean-Pierre, Falgueyret, Prasamit S, Baruah, Olivier, Nicolas, Rino, Stocco, Hugo, Poirier, Giovanni, Martino, Alexanne Bonneau, Fortin, Anne, Roulston, Amandine, Chefson, Stéphane, Dorich, Miguel, St-Onge, Purvish, Patel, Charles, Pellerin, Stéphane, Ciblat, Thomas, Pinter, Francis, Barabé, Majida, El Bakkouri, Paranjay, Parikh, Christian, Gervais, Agnel, Sfeir, Yael, Mamane, Stephen J, Morris, W Cameron, Black, Frank, Sicheri, Michel, Gallant
Publikováno v:
Journal of medicinal chemistry. 65(19)
DNA polymerase theta (Polθ) is an attractive synthetic lethal target for drug discovery, predicted to be efficacious against breast and ovarian cancers harboring BRCA-mutant alleles. Here, we describe our hit-to-lead efforts in search of a selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::531f44b082fb5f00fe6c2f82d97a48bc
https://pubmed.ncbi.nlm.nih.gov/36126059
https://pubmed.ncbi.nlm.nih.gov/36126059
Publikováno v:
Nature structuralmolecular biology. 24(10)
C-type inactivation underlies important roles played by voltage-gated K+ (Kv) channels. Functional studies have provided strong evidence that a common underlying cause of this type of inactivation is an alteration near the extracellular end of the ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::461b17c2784597db2a2138de1c14210c
https://pubmed.ncbi.nlm.nih.gov/28846092
https://pubmed.ncbi.nlm.nih.gov/28846092
Autor:
Victor, Paul
This thesis explores the nature of organisational change and proposes that the majority of change programmes are unsuccessful due to their interventionist orientation. The inherent complexity of organisational change is such that the change needs to
Externí odkaz:
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.490168
