An Auristatin nanoconjugate targeting CXCR4+ leukemic cells blocks acute myeloid leukemia dissemination

Autor: Victor Pallarès, Ugutz Unzueta, Aïda Falgàs, Laura Sánchez-García, Naroa Serna, Alberto Gallardo, Gordon A. Morris, Lorena Alba-Castellón, Patricia Álamo, Jorge Sierra, Antonio Villaverde, Esther Vázquez, Isolda Casanova, Ramon Mangues

Publikováno v: Journal of Hematology & Oncology, Vol 13, Iss 1, Pp 1-19 (2020)

Abstract Background Current acute myeloid leukemia (AML) therapy fails to eliminate quiescent leukemic blasts in the bone marrow, leading to about 50% of patient relapse by increasing AML burden in the bone marrow, blood, and extramedullar sites. We

Externí odkaz: https://doaj.org/article/87ebec6b3f454f2189fdb0bc4e413690

Nicotinamide Prevents Apolipoprotein B-Containing Lipoprotein Oxidation, Inflammation and Atherosclerosis in Apolipoprotein E-Deficient Mice

Autor: Karen Alejandra Méndez-Lara, Nicole Letelier, Núria Farré, Elena M. G. Diarte-Añazco, Núria Nieto-Nicolau, Elisabeth Rodríguez-Millán, David Santos, Victor Pallarès, Joan Carles Escolà-Gil, Tania Vázquez del Olmo, Enrique Lerma, Mercedes Camacho, Ricardo P Casaroli-Marano, Annabel F. Valledor, Francisco Blanco-Vaca, Josep Julve

Publikováno v: Antioxidants, Vol 9, Iss 11, p 1162 (2020)

The potential of nicotinamide (NAM) to prevent atherosclerosis has not yet been examined. This study investigated the effect of NAM supplementation on the development of atherosclerosis in a mouse model of the disease. The development of aortic ather

Externí odkaz: https://doaj.org/article/e738026d6937436985fe0120c638a2ae

Human hepatic lipase overexpression in mice induces hepatic steatosis and obesity through promoting hepatic lipogenesis and white adipose tissue lipolysis and fatty acid uptake.

Autor: Lídia Cedó, David Santos, Núria Roglans, Josep Julve, Victor Pallarès, Andrea Rivas-Urbina, Vicenta Llorente-Cortes, Joan Carles Laguna, Francisco Blanco-Vaca, Joan Carles Escolà-Gil

Publikováno v: PLoS ONE, Vol 12, Iss 12, p e0189834 (2017)

Human hepatic lipase (hHL) is mainly localized on the hepatocyte cell surface where it hydrolyzes lipids from remnant lipoproteins and high density lipoproteins and promotes their hepatic selective uptake. Furthermore, hepatic lipase (HL) is closely

Externí odkaz: https://doaj.org/article/b48655b3720541eb9a1407173133ffdc

Engineering non-antibody human proteins as efficient scaffolds for selective, receptor-targeted drug delivery

Autor: Naroa Serna, Victor Pallarès, Ugutz Unzueta, Annabel Garcia-Leon, Eric Voltà-Durán, Alejandro Sánchez-Chardi, Eloi Parladé, Ariana Rueda, Isolda Casanova, Aïda Falgàs, Lorena Alba-Castellón, Jorge Sierra, Antonio Villaverde, Esther Vázquez, Ramón Mangues

Publikováno v: Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
JOURNAL OF CONTROLLED RELEASE
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname

Altres ajuts: Marató de TV3 Foundation (grant 201941-30-31-32) Self-assembling non-immunoglobulin scaffold proteins are a promising class of nanoscale carriers for drug delivery and interesting alternatives to antibody-based carriers that are not su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9363d9ef783b33ca4d31ebcc4aa95829
https://ddd.uab.cat/record/251876

Specific Cytotoxic Effect of an Auristatin Nanoconjugate Towards CXCR4 + Diffuse Large B-Cell Lymphoma Cells

Autor: Jorge Sierra, Yáiza Núñez, Aïda Falgàs, Patricia Álamo, Ugutz Unzueta, Maria Antonia Mangues, Antonio Villaverde, Esther Vázquez, Isolda Casanova, Victor Pallarès, Ramon Mangues, Alberto Gallardo, Lorena Alba-Castellón

Publikováno v: Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
International Journal of Nanomedicine, Vol Volume 16, Pp 1869-1888 (2021)
International Journal of Nanomedicine
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname

Aïda Falgàs,1– 3 Victor Pallarès,1– 3 Ugutz Unzueta,1– 4 Yáiza Núñez,1,2 Jorge Sierra,2,5 Alberto Gallardo,1 Lorena Alba-Castellón,1,2 Maria Antonia Mangues,3,6 Patricia Álamo,1– 3 Antonio Villaverde,3,4,7 Esther Vázquez,3,4,7 Ramon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bf2c676c4fb367fc146d5b0f85cc075
https://ddd.uab.cat/record/255355