The role of the PIK3CA gene in the development and aging of the brain

Autor: Shaozhen Xie, Jing Ni, Hanbing Guo, Victor Luu, Yanzhi Wang, Jean J. Zhao, Thomas M. Roberts

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)

Abstract The CLOVES syndrome is an overgrowth disease arising from mosaic activating somatic mutations in the PIK3CA gene. These mutations occur during fetal development producing malformation and overgrowth of a variety of tissues. It has recently b

Externí odkaz: https://doaj.org/article/761eb586c798462ba344c27fd5338111

Anticoagulation and Antiplatelet Therapy for Prevention of Venous and Arterial Thrombotic Events in Critically Ill Patients With COVID-19: COVID-PACT

Autor: Erin A. Bohula, David D. Berg, Mathew S. Lopes, Jean M. Connors, Ijlal Babar, Christopher F. Barnett, Sunit-Preet Chaudhry, Amit Chopra, Wilson Ginete, Michael H. Ieong, Jason N. Katz, Edy Y. Kim, Julia F. Kuder, Emilio Mazza, Dalton McLean, Jarrod M. Mosier, Ari Moskowitz, Sabina A. Murphy, Michelle L. O’Donoghue, Jeong-Gun Park, Rajnish Prasad, Christian T. Ruff, Mohamad N. Shahrour, Shashank S. Sinha, Stephen D. Wiviott, Sean Van Diepen, Mark Zainea, Vivian Baird-Zars, Marc S. Sabatine, David A. Morrow, Kyung Ah Im, Retu Saxena, Brandon Wiley, Carina Benson, Roman Delamed, Nedaa Skeik, Ami Chopra, Marc Judson, Scott Beegle, Boris Shkolnik, Anupama Tiwari, Gregory Wu, Abhijit Raval, Emerald Branch, Franz Rischard, Cameron Hypes, Billie Bixby, Christian Bime, Madhan Sundaram, Nancy Sweitzer, Alfredo Vazquez Sandoval, Heath White, Katherine Berg, Shahzad Shaefi, Michael Donnino, Brett Carroll, Michael Ieong, Kimberly Ackerbauer, Jaime Murphy, Ankeet Bhatt, Alexander Blood, Siddharth Patel, Victor Luu, Shraddha Narechania, Austin Lorganger, Robert Plambeck, Ali Nayfeh, Michael Sanley, Michel Del Cor, AJ Hegg, Winston Nara, Michael Snyder, Faisal Khan, Imad Shawa, Joshua Larned, Elias Collado, Mohammed Al Faiyumi, Rajeev Mehta, Sudarshan Komanapalli, Vijayadershan Muppidi, Mehul Desai, Casey Flanagan, Leonard Genovese, Tariq Haddad, Christopher King, Amber Peterson, Thane Htun, Elizabeth Pionk, Nicolas Mouawad, Chintalapudi Kumar, Kevin Nguyen, Majid Mughal, Ryan Malek, Akarsh Parekh, Christopher Provenzano, Melissa Ianitelli, Nicole Prentice-Gaytan, Adam Bykowski, Don Tait, Shelley Schendel, Varun Yalamanchili, Vasim Lala, Victor Hunyadi, Alexander Papolos, Benjamin Kenigsberg, Aarthi Shenoy, Thomas Stuckey, Douglas McQuaid, Praveen Mannam, Jeffrey McClung, Kent Nilsson, Andrew McKown, Jason Wells, David Hotchkin, Marc Jacobs, Wayne Strauss, Rick Balestra, Vikram Sahni, R. Jeffrey Snell, Hussam Suradi, Sarah Sungurlu, Jessica Kuppy, Eileen Gajo, Foster Adams, Abbas Shehadeh, Addi Suleiman, Harish Nandigam, Jihad Slim, Sardar Ijlal Babar, Dipti Baral, Talha Nawaz, Syed Abdullah Waheed, Randy Roth, Subhas Sitaula, Shahid Hayat, Jooby Babu, Jason Caberto, Victor Hsu, Robert Chang, Markian Bochan, Rafael Garcia-Cortes, Hal Skopicki, On Chen, Lauren Pilato, Paul Richman, Alexander Adler, Praveen Sudhindra, Jamie Beversdorf, Ravindra Kashyap, Parth Mehta, Borna Mehrad, Ali Ataya, Jorge Lascano, Mark Brantly, Adam Austin, Eduard Koman, Thomas Galski, Vijaya Kumar, Ayman Soubani, Nicolas Harrison, Vineet Reddy, Audrey Fonkam

Publikováno v: Circulation. 146:1344-1356

Background: The efficacy and safety of prophylactic full-dose anticoagulation and antiplatelet therapy in critically ill COVID-19 patients remain uncertain. Methods: COVID-PACT (Prevention of Arteriovenous Thrombotic Events in Critically-ill COVID-19

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f999083149829e3265fcbf720264111
https://doi.org/10.1161/circulationaha.122.061533

ERα promotes murine hematopoietic regeneration through the Ire1α-mediated unfolded protein response

Autor: Richard H Chapple, Tianyuan Hu, Yu-Jung Tseng, Lu Liu, Ayumi Kitano, Victor Luu, Kevin A Hoegenauer, Takao Iwawaki, Qing Li, Daisuke Nakada

Publikováno v: eLife, Vol 7 (2018)

Activation of the unfolded protein response (UPR) sustains protein homeostasis (proteostasis) and plays a fundamental role in tissue maintenance and longevity of organisms. Long-range control of UPR activation has been demonstrated in invertebrates,

Externí odkaz: https://doaj.org/article/7030bcdb383e4e07a7362260110fcf20

The role of the PIK3CA gene in the development and aging of the brain

Autor: Jing Ni, Shaozhen Xie, Victor Luu, Jean J. Zhao, Thomas M. Roberts, Yanzhi Wang, H Guo

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Scientific Reports

The CLOVES syndrome is an overgrowth disease arising from mosaic activating somatic mutations in the PIK3CA gene. These mutations occur during fetal development producing malformation and overgrowth of a variety of tissues. It has recently been shown

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e87ca95086eeeacae82f245e68f538b
https://doi.org/10.1038/s41598-020-79416-6

Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases

Autor: Quang-Dé Nguyen, Marika Hayashi, Shakti Ramkissoon, Ian E. Krop, Jean J. Zhao, Eric P. Winer, Jing Ni, Shom Goel, Rose Du, Zhigang C. Wang, Shaozhen Xie, Brian M. Alexander, Yun Jee Kang, Elizabeth B. Claus, J. Dirk Iglehart, Victor Luu, Lori A. Ramkissoon, Azra H. Ligon, Keith L. Ligon, H Guo, Thomas M. Roberts, Daniel G. Stover, Nan Lin, Guo-Cheng Yuan, Eugenio Marco

Publikováno v: Nature medicine

Brain metastases represent the greatest clinical challenge in treating HER2-positive breast cancer. We report the development of orthotopic patient-derived xenografts (PDXs) of HER2-expressing breast cancer brain metastases (BCBM), and their use for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb3dcca541ed1b68c753581610f3b99
https://doi.org/10.1038/nm.4120