Zobrazeno 1 - 10
of 339
pro vyhledávání: '"Victor, Faundez"'
Autor:
Chiemela Ohanele, Jessica N. Peoples, Anja Karlstaedt, Joshua T. Geiger, Ashley D. Gayle, Nasab Ghazal, Fateemaa Sohani, Milton E. Brown, Michael E. Davis, George A. Porter, Victor Faundez, Jennifer Q. Kwong
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract The developing mammalian heart undergoes an important metabolic shift from glycolysis towards mitochondrial oxidation that is critical to support the increasing energetic demands of the maturing heart. Here, we describe a new mechanistic lin
Externí odkaz:
https://doaj.org/article/303b6bcf721b461cb58adc8d83829c32
Autor:
Thomas S. Wingo, Yue Liu, Ekaterina S. Gerasimov, Selina M. Vattathil, Meghan E. Wynne, Jiaqi Liu, Adriana Lori, Victor Faundez, David A. Bennett, Nicholas T. Seyfried, Allan I. Levey, Aliza P. Wingo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Studying the shared genetic etiology of disease can help improve diagnosis and treatment. Here, the authors find evidence for shared genetic and molecular pathophysiology between several common psychiatric and neurodegenerative diseases using results
Externí odkaz:
https://doaj.org/article/b0d7b7da35414544b542e983ada6206d
Autor:
Meghan E Wynne, Oluwaseun Ogunbona, Alicia R Lane, Avanti Gokhale, Stephanie A Zlatic, Chongchong Xu, Zhexing Wen, Duc M Duong, Sruti Rayaprolu, Anna Ivanova, Eric A Ortlund, Eric B Dammer, Nicholas T Seyfried, Blaine R Roberts, Amanda Crocker, Vinit Shanbhag, Michael Petris, Nanami Senoo, Selvaraju Kandasamy, Steven Michael Claypool, Antoni Barrientos, Aliza Wingo, Thomas S Wingo, Srikant Rangaraju, Allan I Levey, Erica Werner, Victor Faundez
Publikováno v:
eLife, Vol 12 (2023)
Mitochondria influence cellular function through both cell-autonomous and non-cell autonomous mechanisms, such as production of paracrine and endocrine factors. Here, we demonstrate that mitochondrial regulation of the secretome is more extensive tha
Externí odkaz:
https://doaj.org/article/f59364e09ba749e59bd95488824ad15b
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104920- (2022)
Summary: The human brain consumes five orders of magnitude more energy than the sun by unit of mass and time. This staggering bioenergetic cost serves mostly synaptic transmission and actin cytoskeleton dynamics. The peak of both brain bioenergetic d
Externí odkaz:
https://doaj.org/article/7455b54fbdb8458e819b7d849b71b95e
Autor:
Stephanie A. Zlatic, Duc Duong, Kamal K.E. Gadalla, Brenda Murage, Lingyan Ping, Ruth Shah, James J. Fink, Omar Khwaja, Lindsay C. Swanson, Mustafa Sahin, Sruti Rayaprolu, Prateek Kumar, Srikant Rangaraju, Adrian Bird, Daniel Tarquinio, Randall Carpenter, Stuart Cobb, Victor Faundez
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104966- (2022)
Summary: MECP2 loss-of-function mutations cause Rett syndrome, a neurodevelopmental disorder resulting from a disrupted brain transcriptome. How these transcriptional defects are decoded into a disease proteome remains unknown. We studied the proteom
Externí odkaz:
https://doaj.org/article/3dab4af82ddd47d782dbe33e5cc615d1
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-11 (2021)
Abstract Homeostatic plasticity is necessary for the construction and maintenance of functional neuronal networks, but principal molecular mechanisms required for or modified by homeostatic plasticity are not well understood. We recently reported tha
Externí odkaz:
https://doaj.org/article/a2c0d9e2346a4523b42a27104047f206
Autor:
Alicia Lane, Avanti Gokhale, Erica Werner, Anne Roberts, Amanda Freeman, Blaine Roberts, Victor Faundez
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101334- (2022)
Summary: This protocol describes how inductively coupled plasma mass spectrometry (ICP-MS) can quantify metals, sulfur, and phosphorus present in biological specimens. The high sensitivity of ICP-MS enables detection of these elements at very low con
Externí odkaz:
https://doaj.org/article/1d1509d150b34bda848e3dd3186700df
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Mitochondrial dysfunction has long been overlooked in neurodevelopmental disorders, but recent studies have provided new links to genetic forms of autism, including Rett syndrome and fragile X syndrome (FXS). Mitochondria show plasticity in morpholog
Externí odkaz:
https://doaj.org/article/ade2459549a54ab1b19f48e1bfe30a5e
Publikováno v:
STAR Protocols, Vol 1, Iss 2, Pp 100083- (2020)
Summary: This protocol describes immunoprecipitation of proteins associated with FLAG-tagged recombinant proteins followed by mass spectrometry-based proteomics to identify the associated interactome components. FLAG epitope was chosen, because exist
Externí odkaz:
https://doaj.org/article/b3b66f27e4f14c0495e06102fb834708
Autor:
Arielle N. Valdez-Sinon, Austin Lai, Liang Shi, Carly L. Lancaster, Avanti Gokhale, Victor Faundez, Gary J. Bassell
Publikováno v:
iScience, Vol 23, Iss 5, Pp - (2020)
Summary: Maintaining a balance between protein degradation and protein synthesis is necessary for neurodevelopment. Although the E3 ubiquitin ligase anaphase promoting complex and its regulatory subunit Cdh1 (Cdh1-APC) has been shown to regulate lear
Externí odkaz:
https://doaj.org/article/5a6cf85b112447ba8e3151ff271806fc