Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Vicky M. Houtzager"'
Autor:
Kevin T. Chapman, Tracy Timkey, Margarita Garcia-Calvo, Vicky M. Houtzager, Dita M. Rasper, Donald W. Nicholson, Erin P. Peterson, Nancy A. Thornberry, Thomas A. Rano, Sophie Roy, John P. Vaillancourt, Penny A. Nordstrom
Publikováno v:
Journal of Biological Chemistry. 272:17907-17911
There is compelling evidence that members of the caspase (interleukin-1beta converting enzyme/CED-3) family of cysteine proteases and the cytotoxic lymphocyte-derived serine protease granzyme B play essential roles in mammalian apoptosis. Here we use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3014846097bb3ec6545e1dc033de57e9
https://doi.org/10.1074/jbc.272.29.17907
https://doi.org/10.1074/jbc.272.29.17907
Autor:
M. Metzler, Pamela A. Hoodless, Rebecca L. Cullum, Robin J. Dickinson, Caroline Houde, Elizabeth M. Simpson, Donald W. Nicholson, Vicky M. Houtzager, Rachel Montpetit, Michael R. Hayden, Sophie Roy
Hippi functions as an adapter protein that mediates pro-apoptotic signaling from poly-glutamine-expanded huntingtin, an established cause of Huntington disease, to the extrinsic cell death pathway. To explore other functions of Hippi we generated Hip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0860abbe78ddbff1e3c100214ce2e82c
https://europepmc.org/articles/PMC5053816/
https://europepmc.org/articles/PMC5053816/
Autor:
John Tam, Sophie Roy, Claire-Anne Gutekunst, Dita M. Rasper, Abigail S. Hackam, Vicky M. Houtzager, François G. Gervais, Martina Metzler, John P. Vaillancourt, Steven Xanthoudakis, Donald W. Nicholson, Michael R. Hayden, Blair R. Leavitt, Roshni R. Singaraja
Publikováno v:
Nature cell biology. 4(2)
In Huntington disease, polyglutamine expansion of the protein huntingtin (Htt) leads to selective neurodegenerative loss of medium spiny neurons throughout the striatum by an unknown apoptotic mechanism. Binding of Hip-1, a protein normally associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0f437373889e50aa303924911c8768c
https://pubmed.ncbi.nlm.nih.gov/11835052
https://pubmed.ncbi.nlm.nih.gov/11835052
Autor:
Isolde M. Seiden, Christopher I. Bayly, Sophie Roy, Stacia Kargman, Sabina L.C. Keen, Yves Gareau, Kathleen J. Rowland, Nancy A. Thornberry, Donald W. Nicholson, Vicky M. Houtzager
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 98(11)
Caspase-3 is synthesized as a dormant proenzyme and is maintained in an inactive conformation by an Asp-Asp-Asp “safety-catch” regulatory tripeptide contained within a flexible loop near the large-subunit/small-subunit junction. Removal of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0212937efabc9b650d570e7b75f3108
https://pubmed.ncbi.nlm.nih.gov/11353841
https://pubmed.ncbi.nlm.nih.gov/11353841
Autor:
Donald W. Nicholson, Sophie Roy, Erin P. Peterson, Felicita Hornung, John P. Vaillancourt, Ben F. Koop, Paul Tawa, Jing Qi Huang, David P. MacPherson, Sabina L.C. Keen, Nancy A. Thornberry, Michael R. Hayden, Jamal Nasir, Dita M. Rasper, Isolde M. Seiden, Steve Xanthoudakis, Shawn C. Black, Michael J. Lenardo, Vicky M. Houtzager, Shinji Hadano, Duane Martindale
Publikováno v:
Scopus-Elsevier
Apoptotic cell suicide initiated by ligation of CD95 (Fas/APO-1) occurs through recruitment, oligomerization and autocatalytic activation of the cysteine protease, caspase-8 (MACH, FLICE, Mch5). An endogenous mammalian regulator of this process, name
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d5546e537c5c672fa3486b6e135a0f
https://pubmed.ncbi.nlm.nih.gov/10200473
https://pubmed.ncbi.nlm.nih.gov/10200473