Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Vicky L. Kett"'
Autor:
Cian M. McCrudden, John W. McBride, Joanne McCaffrey, Emma M. McErlean, Nicholas J. Dunne, Vicky L. Kett, Jonathan A. Coulter, Tracy Robson, Helen O. McCarthy
Publikováno v:
Cancer Nanotechnology, Vol 9, Iss 1, Pp 1-15 (2018)
Abstract Background Recent approvals of gene therapies by the FDA and the EMA for treatment of inherited disorders have further opened the door for assessment of nucleic acid pharmaceuticals for clinical usage. Arising from the presence of damaged or
Externí odkaz:
https://doaj.org/article/9ed2bf465afb41bba08a79b15b46f23a
Autor:
Cian M. McCrudden, John W. McBride, Joanne McCaffrey, Ahlam A. Ali, Nicholas J. Dunne, Vicky L. Kett, Jonathan A. Coulter, Tracy Robson, Helen O. McCarthy
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 6, Iss , Pp 249-258 (2017)
This study aimed to determine the therapeutic benefit of a nanoparticular formulation for the delivery of inducible nitric oxide synthase (iNOS) gene therapy in a model of breast cancer metastasis. Nanoparticles comprising a cationic peptide vector,
Externí odkaz:
https://doaj.org/article/6e5a1d3407dd4a3ab97c5e21c1d9b806
Autor:
Lynn N Jena, Lindsey A Bennie, Emma M McErlean, Sreekanth Pentlavalli, Kim Glass, James F Burrows, Vicky L Kett, Niamh E Buckley, Jonathan A Coulter, Nicholas J Dunne, Helen O McCarthy
Publikováno v:
Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-18 (2021)
Abstract Glioblastoma multiforme (GBM) is an incurable aggressive brain cancer in which current treatment strategies have demonstrated limited survival benefit. In recent years, nitrogen-containing bisphosphonates (N-BPs) have demonstrated direct ant
Externí odkaz:
https://doaj.org/article/ff00e18b61e540388dddf96e6bc47180
Publikováno v:
Clinical and Translational Imaging. 11:33-50
The application of contrast and tracing agents is essential for lung imaging, as indicated by the wide use in recent decades and the discovery of various new contrast and tracing agents. Different aerosol production and pulmonary administration metho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3915443441478543a3ddd57593f014eb
https://doi.org/10.1007/s40336-022-00527-3
https://doi.org/10.1007/s40336-022-00527-3
Autor:
Eoghan J. Mulholland, Monika Ziminska, Tracy Robson, Grace Cole, Vicky L. Kett, Helen O. McCarthy, Emma M. McErlean, Nicholas Dunne, Cian M. McCrudden, Niamh E. Buckley, John W. McBride, Stephen P. Loughran
Publikováno v:
McErlean, E M, Ziminska, M, McCrudden, C M, McBride, J W, Loughran, S P, Cole, G, Mulholland, E J, Kett, V, Buckley, N E, Robson, T, Dunne, N J & McCarthy, H O 2020, ' Rational design and characterisation of a linear cell penetrating peptide for non-viral gene delivery ', Journal of Controlled Release, vol. 330, pp. 1288 . https://doi.org/10.1016/j.jconrel.2020.11.037
The design of a non-viral gene delivery system that can release a functional nucleic acid at the intracellular destination site is an exciting but also challenging proposition. The ideal gene delivery vector must be non-toxic, non-immunogenic, overco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f03a6e561e7b2be5887b475b411cf9e
https://doi.org/10.1016/j.jconrel.2020.11.037
https://doi.org/10.1016/j.jconrel.2020.11.037
Publikováno v:
Munir, M, Kett, V L, Dunne, N J & McCarthy, H O 2022, ' Development of a Spray-Dried Formulation of Peptide-Dna Nanoparticles into a Dry Powder for Pulmonary Delivery Using Factorial Design ', Pharmaceutical Research . https://doi.org/10.1007/s11095-022-03256-4
Background Gene therapy via pulmonary delivery holds the potential to treat various lung pathologies. To date, spray drying has been the most promising method to produce inhalable powders. The present study determined the parameters required to spray
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9bdfbacf26c9b4f4c16ba2049c96739
https://pubmed.ncbi.nlm.nih.gov/35441318
https://pubmed.ncbi.nlm.nih.gov/35441318
Autor:
Cian M. McCrudden, Emma M. McErlean, Ryan F. Donnelly, Vicky L. Kett, Tracy Robson, Amy Short, Ahlam A. Ali, Joanne McCaffrey, Grace Cole, Eoghan J. Mulholland, Helen O. McCarthy, Nicholas Dunne, Jonathan A. Coulter
Publikováno v:
Cole, G, Ali, A A, McErlean, E, Mulholland, E J, Short, A, McCrudden, C M, McCaffrey, J, Robson, T, Kett, V L, Coulter, J A, Dunne, N J, Donnelly, R F & McCarthy, H O 2019, ' DNA vaccination via RALA nanoparticles in a microneedle delivery system induces a potent immune response against the endogenous prostate cancer stem cell antigen ', Acta Biomaterialia, vol. 96, pp. 480 . https://doi.org/10.1016/j.actbio.2019.07.003
Castrate resistant prostate cancer (CRPC) remains a major challenge for healthcare professionals. Immunotherapeutic approaches, including DNA vaccination, hold the potential to harness the host's own immune system to mount a cell-mediated, anti-tumou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e07b42cca780169c2d602a665e4ce2e
https://doi.org/10.1016/j.actbio.2019.07.003
https://doi.org/10.1016/j.actbio.2019.07.003
Autor:
Jonathan A. Coulter, Lynn Jena, Sreekanth Pentlavalli, Kim Glass, Emma M. McErlean, Vicky L. Kett, James F Burrows, Helen O. McCarthy, Nicholas Dunne, Niamh E. Buckley, Lindsey A. Bennie
Publikováno v:
Jena, L N, Bennie, L A, McErlean, E M, Pentlavalli, S, Glass, K, Burrows, J F, Kett, V L, Buckley, N E, Coulter, J A, Dunne, N J & McCarthy, H O 2021, ' Exploiting the anticancer effects of a nitrogen bisphosphonate nanomedicine for glioblastoma multiforme ', Journal of nanobiotechnology, vol. 19, no. 1, pp. 127 . https://doi.org/10.1186/s12951-021-00856-x
Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-18 (2021)
Journal of Nanobiotechnology
Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-18 (2021)
Journal of Nanobiotechnology
Glioblastoma multiforme (GBM) is an incurable aggressive brain cancer in which current treatment strategies have demonstrated limited survival benefit. In recent years, nitrogen-containing bisphosphonates (N-BPs) have demonstrated direct anticancer e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5fd62a8397daa946dc9e10610f5beba
https://pure.qub.ac.uk/en/publications/149b5aea-d54e-4114-aa43-e4f5d6a59842
https://pure.qub.ac.uk/en/publications/149b5aea-d54e-4114-aa43-e4f5d6a59842
Autor:
Nicholas Dunne, Vicky L. Kett, Emma M. McErlean, John W. McBride, Helen O. McCarthy, Grace Cole, Tracy Robson, Cian M. McCrudden
Publikováno v:
McErlean, E M, McCrudden, C M, McBride, J W, Cole, G, Kett, V L, Robson, T, Dunne, N J & McCarthy, H O 2021, ' Rational design and characterisation of an amphipathic cell penetrating peptide for non-viral gene delivery ', International Journal of Pharmaceutics, vol. 596, 120223 . https://doi.org/10.1016/j.ijpharm.2021.120223
RALA is a cationic amphipathic peptide which has shown great promise as an efficient, multifunctional delivery system for the delivery of nucleic acids. Rational peptide design was utilised in this study to understand the essential amino acids requir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::310944210b5710bbba2c12c7f036ad05
https://pure.qub.ac.uk/en/publications/5c53cc9b-589a-4890-9376-eff2d5754056
https://pure.qub.ac.uk/en/publications/5c53cc9b-589a-4890-9376-eff2d5754056
Autor:
Tracey Robson, John W. McBride, Helen O. McCarthy, Nicholas Dunne, Joanne McCaffrey, Ryan F. Donnelly, Vicky L. Kett, Grace Cole, Cian M. McCrudden, Ahlam A. Ali
Publikováno v:
Cole, G, Ali, A, McCrudden, C, McBride, J, McCaffrey, J, Robson, T, Kett, V, Dunne, N, Donnelly, R & McCarthy, H 2018, ' DNA vaccination for cervical cancer: Strategic optimisation of RALA mediated gene delivery from a biodegradable microneedle system. ', European Journal of Pharmaceutics and Biopharmaceutics, vol. 127, pp. 288-297 . https://doi.org/10.1016/j.ejpb.2018.02.029
Dissolvable microneedles can be employed to deliver DNA to antigen presenting cells within the skin. However, this technology faces two main challenges: the poor transfection efficacy of pDNA following release from the microneedle matrix, and the lim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac467b0bd684a7230556b311aa2876d
https://doi.org/10.1016/j.ejpb.2018.02.029
https://doi.org/10.1016/j.ejpb.2018.02.029