Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Vicky E Macrae"'
Publikováno v:
Frontiers in Endocrinology, Vol 3 (2012)
Vascular calcification has severe clinical consequences and is considered an accurate predictor of future adverse cardiovascular events, including myocardial infarction and stroke. Previously vascular calcification was thought to be a passive process
Externí odkaz:
https://doaj.org/article/d98edf694e6649e4b59a4eb9a57cb4c0
Publikováno v:
Frontiers in Veterinary Science, Vol 10 (2023)
BackgroundTGFβ signaling appears to contribute to the pathogenesis of myxomatous mitral valve disease (MMVD) in both dogs and humans. However, little is known about the extent of the downstream signaling changes that will then affect cell phenotype
Externí odkaz:
https://doaj.org/article/2f3478e8fd424d18a0516a1ff155b0bd
Autor:
Karla J. Suchacki, Nicholas M. Morton, Calvin Vary, Carmen Huesa, Manisha C. Yadav, Benjamin J. Thomas, Sophie Turban, Lutz Bunger, Derek Ball, Martin E. Barrios-Llerena, Anyonya R. Guntur, Zohreh Khavandgar, William P. Cawthorn, Mathieu Ferron, Gérard Karsenty, Monzur Murshed, Clifford J. Rosen, Vicky E. MacRae, Jose Luis Millán, Colin Farquharson
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-20 (2020)
Abstract Background The classical functions of the skeleton encompass locomotion, protection and mineral homeostasis. However, cell-specific gene deletions in the mouse and human genetic studies have identified the skeleton as a key endocrine regulat
Externí odkaz:
https://doaj.org/article/23dc81b350d5458086f9e23af1515cc1
Autor:
Shen Li, Tomohiro Yokota, Ping Wang, Johanna ten Hoeve, Feiyang Ma, Thuc M. Le, Evan R. Abt, Yonggang Zhou, Rimao Wu, Maxine Nanthavongdouangsy, Abraham Rodriguez, Yijie Wang, Yen-Ju Lin, Hayato Muranaka, Mark Sharpley, Demetrios T. Braddock, Vicky E. MacRae, Utpal Banerjee, Pei-Yu Chiou, Marcus Seldin, Dian Huang, Michael Teitell, Ilya Gertsman, Michael Jung, Steven J. Bensinger, Robert Damoiseaux, Kym Faull, Matteo Pellegrini, Aldons J. Lusis, Thomas G. Graeber, Caius G. Radu, Arjun Deb
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 2 (2022)
Various populations of cells are recruited to the heart after cardiac injury, but little is known about whether cardiomyocytes directly regulate heart repair. Using a murine model of ischemic cardiac injury, we demonstrate that cardiomyocytes play a
Externí odkaz:
https://doaj.org/article/4f249dd668874f6a904b120bd8b43144
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Mitochondria are crucial bioenergetics powerhouses and biosynthetic hubs within cells, which can generate and sequester toxic reactive oxygen species (ROS) in response to oxidative stress. Oxidative stress-stimulated ROS production results in ATP dep
Externí odkaz:
https://doaj.org/article/015be75ad5d444fd95e8f8ecdccc05a6
Autor:
Dean A. Houston, Louise A. Stephen, Soher N. Jayash, Katherine Myers, Kirsty Little, Mark Hopkinson, Andrew A. Pitsillides, Vicky E. MacRae, Jose Luis Millan, Katherine A. Staines, Colin Farquharson
Publikováno v:
Cell Biochemistry and Function. 41:189-201
The administration of intermittent parathyroid hormone (iPTH) is anabolic to the skeleton. Recent studies with cultured osteoblasts have revealed that the expression of PHOSPHO1, a bone-specific phosphatase essential for the initiation of mineralisat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9980129c74d7ff8406be9f785e25fbb7
https://doi.org/10.1002/cbf.3772
https://doi.org/10.1002/cbf.3772
Autor:
Qiyu Tang, Greg R. Markby, Andrew J. MacNair, Keyi Tang, Michal Tkacz, Maciej Parys, Kanchan Phadwal, Vicky E. MacRae, Brendan M. Corcoran
Publikováno v:
Cell Proliferation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d311cad44dcfaa06cbd246b5eb9ffc31
https://doi.org/10.1111/cpr.13435
https://doi.org/10.1111/cpr.13435
Publikováno v:
Wang, Q, Dai, X, MacRae, V E & Song, P 2022, ' Vascular smooth muscle cell fate and vascular remodeling: Mechanisms, therapeutic targets, and drugs, volume I ', Frontiers in pharmacology, vol. 13, 989689 . https://doi.org/10.3389/fphar.2022.989689
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fa3695e3dc362c18b4854bda0e01311
https://pubmed.ncbi.nlm.nih.gov/36052123
https://pubmed.ncbi.nlm.nih.gov/36052123
Publikováno v:
Tang, P, Mcnair, A, Phadwal, K, MacRae, V & Corcoran, B 2022, ' The Role of Transforming Growth Factor-β Signaling in Myxomatous Mitral Valve Degeneration ', Frontiers in Cardiovascular Medicine, vol. 9, 872288 . https://doi.org/10.3389/fcvm.2022.872288
Mitral valve prolapse (MVP) due to myxomatous degeneration is one of the most important chronic degenerative cardiovascular diseases in people and dogs. It is a common cause of heart failure leading to significant morbidity and mortality in both spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a0604a3f9ae7a7a90c67d8619f8bcd
https://www.pure.ed.ac.uk/ws/files/266540688/fcvm_09_872288.pdf
https://www.pure.ed.ac.uk/ws/files/266540688/fcvm_09_872288.pdf
Publikováno v:
Journal of Endocrinology. 245:R11-R22
The physiological mineralisation of skeletal tissues, as well as the pathological mineralisation of soft tissues involves a fine balance between regulators that either promote or inhibit the process. In recent years, several studies have advocated a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b6011e55459267d089f36609ed8b692
https://doi.org/10.1530/joe-19-0460
https://doi.org/10.1530/joe-19-0460