Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Vicky Chou"'
Autor:
Vicky Chou, Richard V. Pearse, Aimee J. Aylward, Nancy Ashour, Mariko Taga, Gizem Terzioglu, Masashi Fujita, Seeley B. Fancher, Alina Sigalov, Courtney R. Benoit, Hyo Lee, Matti Lam, Nicholas T. Seyfried, David A. Bennett, Philip L. De Jager, Vilas Menon, Tracy L. Young-Pearse
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)
Abstract Microglia and neuroinflammation play an important role in the development and progression of Alzheimer’s disease (AD). Inositol polyphosphate-5-phosphatase D (INPP5D/SHIP1) is a myeloid-expressed gene genetically-associated with AD. Throug
Externí odkaz:
https://doaj.org/article/9e3d8cd8d32347f6b00af0ac1594f3b7
Autor:
Hyo Lee, Aimee J. Aylward, Richard V. Pearse, II, Alexandra M. Lish, Yi-Chen Hsieh, Zachary M. Augur, Courtney R. Benoit, Vicky Chou, Allison Knupp, Cheryl Pan, Srilakshmi Goberdhan, Duc M. Duong, Nicholas T. Seyfried, David A. Bennett, Mariko F. Taga, Kevin Huynh, Matthias Arnold, Peter J. Meikle, Philip L. De Jager, Vilas Menon, Jessica E. Young, Tracy L. Young-Pearse
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112994- (2023)
Summary: SORL1 is implicated in the pathogenesis of Alzheimer’s disease (AD) through genetic studies. To interrogate the roles of SORL1 in human brain cells, SORL1-null induced pluripotent stem cells (iPSCs) were differentiated to neuron, astrocyte
Externí odkaz:
https://doaj.org/article/911ab12d4ed045b69c2a0c7474867a7a
Autor:
Erica L Gorenberg, Sofia Massaro Tieze, Betül Yücel, Helen R Zhao, Vicky Chou, Gregory S Wirak, Susumu Tomita, TuKiet T Lam, Sreeganga S Chandra
Publikováno v:
PLoS Biology, Vol 20, Iss 3, p e3001590 (2022)
Loss-of-function mutations in the depalmitoylating enzyme palmitoyl protein thioesterase 1 (PPT1) cause neuronal ceroid lipofuscinosis (NCL), a devastating neurodegenerative disease. The substrates of PPT1 are largely undescribed, posing a limitation
Externí odkaz:
https://doaj.org/article/2b17440e1d874180bbcb43c2eb4e0aab
Publikováno v:
Trends in Neurosciences. 46:426-444
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b3d60a4c4e0460495953c383b4c5fd3
https://doi.org/10.1016/j.tins.2023.03.005
https://doi.org/10.1016/j.tins.2023.03.005
Autor:
Hyo Lee, Aimee J. Aylward, Richard V. Pearse, Yi-Chen Hsieh, Zachary M. Augur, Courtney R. Benoit, Vicky Chou, Allison Knupp, Cheryl Pan, Srilakshmi Goberdhan, Duc M. Duong, Nicholas T. Seyfried, David A. Bennett, Hans-Ulrich Klein, Philip L. De Jager, Vilas Menon, Jessica E. Young, Tracy L. Young-Pearse
Publikováno v:
bioRxiv
SummarySORL1 is strongly implicated in the pathogenesis of Alzheimer’s disease (AD) through human genetic studies that point to an association of reduced SORL1 levels with higher risk for AD. To interrogate the role(s) of SORL1 in human brain cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f5ca35d64f619357003633b6b32402a
https://doi.org/10.1101/2023.02.25.530017
https://doi.org/10.1101/2023.02.25.530017
Autor:
Dylan V Neel, Himanish Basu, Georgia Gunner, Matthew D Bergstresser, Richard M. Giadone, Haeji Chung, Rui Miao, Vicky Chou, Eliza M. Brody, Xin Jiang, Edward B. Lee, Christine Marques, Aaron Held, Brian Wainger, Clotilde Lagier-Tourenne, Yong-Jie Zhang, Leonard Petrucelli, Tracy L. Young-Pearse, Alice S Chen-Plotkin, Lee L. Rubin, Judy Lieberman, Isaac M Chiu
SummaryMitochondrial dysfunction and axon loss are hallmarks of neurologic diseases. Gasdermin (GSDM) proteins are executioner pore-forming molecules that mediate cell death, yet their roles in the central nervous system (CNS) are not well understood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bea31c31776a3ce2a086b6cc022faa8
https://doi.org/10.1101/2022.11.01.513927
https://doi.org/10.1101/2022.11.01.513927
Autor:
Dylan V. Neel, Himanish Basu, Georgia Gunner, Matthew D. Bergstresser, Richard M. Giadone, Haeji Chung, Rui Miao, Vicky Chou, Eliza Brody, Xin Jiang, Edward Lee, Michelle E. Watts, Christine Marques, Aaron Held, Brian Wainger, Clotilde Lagier-Tourenne, Yong-Jie Zhang, Leonard Petrucelli, Tracy L. Young-Pearse, Alice S. Chen-Plotkin, Lee L. Rubin, Judy Lieberman, Isaac M. Chiu
Publikováno v:
Neuron. 111:1222-1240.e9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8eebeb12852883915eae6742b8988c12
https://doi.org/10.1016/j.neuron.2023.02.019
https://doi.org/10.1016/j.neuron.2023.02.019
Autor:
Erica L. Gorenberg, Sofia Massaro Tieze, Betül Yücel, Helen R. Zhao, Vicky Chou, Gregory S. Wirak, Susumu Tomita, TuKiet T. Lam, Sreeganga S. Chandra
Publikováno v:
PLoS biology. 20(3)
Loss-of-function mutations in the depalmitoylating enzyme palmitoyl protein thioesterase 1 (PPT1) cause neuronal ceroid lipofuscinosis (NCL), a devastating neurodegenerative disease. The substrates of PPT1 are largely undescribed, posing a limitation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8469c9a14cedf473a333105d98c76191
https://pubmed.ncbi.nlm.nih.gov/35358180
https://pubmed.ncbi.nlm.nih.gov/35358180
Autor:
Erica L. Gorenberg, Susumu Tomita, Betul Yücel, Gregory S. Wirak, Vicky Chou, Sofia M. Tieze, Helen R. Zhao, Sreeganga S. Chandra, TuKiet T. Lam
SUMMARYLoss-of-function mutations in the depalmitoylating enzyme palmitoyl protein thioesterase 1 (PPT1) cause Neuronal Ceroid Lipofuscinosis type 1 (CLN1), a devastating neurodegenerative disease. Here, we provide a resource identifying PPT1 substra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::453f969c5669f4b3e6aa09ef79c9684d
https://doi.org/10.1101/2020.05.02.074302
https://doi.org/10.1101/2020.05.02.074302
Autor:
Valentina N. Lagomarsino, Vilas Menon, Courtney R. Benoit, Tracy L. Young-Pearse, Scott Noggle, Hyo Lee, Daniel Paull, Lei Liu, Maria A. Vicent, Marty A. Fernandez, Duc M. Duong, Christina Muratore, Monica Zhou, Daniel Felsky, Vicky Chou, Jonathan M.S. Stricker, Fatmata Bah, Dennis J. Selkoe, Seeley B. Fancher, Badri N. Vardarajan, Shinya Tasaki, Chris Gaiteri, Jishu Xu, Amy He, Yi-Chen Hsieh, Philip L. De Jager, Julie P. Merchant, Eric B. Dammer, Nicholas T. Seyfried, Richard V. Pearse, Allan I. Levey, Elizabeth A. Vinton, Hector Martinez, David A. Bennett, Lori B. Chibnik
Publikováno v:
Neuron
We have generated a controlled and manipulable resource that captures genetic risk for Alzheimer’s disease: iPSC lines from 53 individuals coupled with RNA and proteomic profiling of both iPSC-derived neurons and from brain tissue of the same indiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac661fc26257d13a6c572ea1841d1494
https://doi.org/10.1016/j.neuron.2021.08.003
https://doi.org/10.1016/j.neuron.2021.08.003