Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Vicky Caveliers"'
Autor:
Herlinde Dierick, Laurent Navarro, Hannelore Ceuppens, Thomas Ertveldt, Ana Rita Pombo Antunes, Marleen Keyaerts, Nick Devoogdt, Karine Breckpot, Matthias D’Huyvetter, Tony Lahoutte, Vicky Caveliers, Jessica Bridoux
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 9, Iss 1, Pp 1-14 (2024)
Abstract Background Radiofluorination of single domain antibodies (sdAbs) via N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB) has shown to be a promising strategy in the development of sdAb-based PET tracers. While automation of the prosthetic group
Externí odkaz:
https://doaj.org/article/c33569c4b08a436991ec3e0f3cbbf9ab
Autor:
Clarita Saldarriaga Vargas, Lara Struelens, Matthias D’Huyvetter, Vicky Caveliers, Peter Covens
Publikováno v:
EJNMMI Physics, Vol 9, Iss 1, Pp 1-21 (2022)
Abstract Background In order to acquire accurate drug pharmacokinetic information, which is required for tissue dosimetry, micro-SPECT must be quantitative to allow for an accurate assessment of radioligand activity in the relevant tissue. This study
Externí odkaz:
https://doaj.org/article/f97e01e41d3b402eab0b880c86e24c8e
Autor:
Chloé Ackaert, Natalia Smiejkowska, Catarina Xavier, Yann G. J. Sterckx, Sofie Denies, Benoit Stijlemans, Yvon Elkrim, Nick Devoogdt, Vicky Caveliers, Tony Lahoutte, Serge Muyldermans, Karine Breckpot, Marleen Keyaerts
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Nanobodies (Nbs), the variable domains of camelid heavy chain-only antibodies, are a promising class of therapeutics or in vivo imaging reagents entering the clinic. They possess unique characteristics, including a minimal size, providing fast pharma
Externí odkaz:
https://doaj.org/article/d0675eea2e384e6ba27da35657ce2a41
Autor:
Constantijn Raaymakers, Elin Verbrugghe, Sophie Hernot, Tom Hellebuyck, Cecilia Betti, Cindy Peleman, Myriam Claeys, Wim Bert, Vicky Caveliers, Steven Ballet, An Martel, Frank Pasmans, Kim Roelants
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
To avoid being eaten, poisonous prey animals must rely on fast passage of toxins across a predator’s oral tissue, a major barrier to large molecules. Here, Raaymakers et al. show that antimicrobial peptides co secreted with frog toxins enhance into
Externí odkaz:
https://doaj.org/article/71406291176f47ba9bab737724a02083
Autor:
Dora Mugoli Chigoho, Quentin Lecocq, Robin Maximilian Awad, Karine Breckpot, Nick Devoogdt, Marleen Keyaerts, Vicky Caveliers, Catarina Xavier, Jessica Bridoux
Publikováno v:
Pharmaceuticals, Vol 14, Iss 6, p 550 (2021)
Immune checkpoint inhibitors targeting the programmed cell death-1 (PD-1) and its ligand PD-L1 have proven to be efficient cancer therapies in a subset of patients. From all the patients with various cancer types, only 20% have a positive response. B
Externí odkaz:
https://doaj.org/article/b035fb38af9f49a79cd4caa88ac237cb
Autor:
Henri Baudhuin, Julie Cousaert, Philippe Vanwolleghem, Geert Raes, Vicky Caveliers, Marleen Keyaerts, Tony Lahoutte, Catarina Xavier
Publikováno v:
Pharmaceuticals, Vol 14, Iss 5, p 448 (2021)
During the preparation of [68Ga]Ga-NOTA-sdAb at high activity, degradation of the tracers was observed, impacting the radiochemical purity (RCP). Increasing starting activities in radiolabelings is often paired with increased degradation of the trace
Externí odkaz:
https://doaj.org/article/c47f334fd77242578fdf4e0b0e7ad62f
Autor:
Jessica Bridoux, Katrijn Broos, Quentin Lecocq, Pieterjan Debie, Charlotte Martin, Steven Ballet, Geert Raes, Sara Neyt, Christian Vanhove, Karine Breckpot, Nick Devoogdt, Vicky Caveliers, Marleen Keyaerts, Catarina Xavier
Publikováno v:
Biomolecules, Vol 10, Iss 10, p 1388 (2020)
Immune checkpoints, such as programmed death-ligand 1 (PD-L1), limit T-cell function and tumor cells use this ligand to escape the anti-tumor immune response. Treatments with monoclonal antibodies blocking these checkpoints have shown long-lasting re
Externí odkaz:
https://doaj.org/article/0a79df813fc14ca586b2889dfaa8dd9e
Autor:
Jessica Bridoux, Sara Neyt, Pieterjan Debie, Benedicte Descamps, Nick Devoogdt, Frederik Cleeren, Guy Bormans, Alexis Broisat, Vicky Caveliers, Catarina Xavier, Christian Vanhove, Sophie Hernot
Publikováno v:
Molecules, Vol 25, Iss 8, p 1838 (2020)
Since atherosclerotic plaques are small and sparse, their non-invasive detection via PET imaging requires both highly specific radiotracers as well as imaging systems with high sensitivity and resolution. This study aimed to assess the targeting and
Externí odkaz:
https://doaj.org/article/c07ffba28b0a467fa5470b052f1b6618
Autor:
Marleen Keyaerts, Isabel Remory, Vicky Caveliers, Karine Breckpot, Tomas J Bos, Jan Poelaert, Axel Bossuyt, Tony Lahoutte
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30061 (2012)
UNLABELLED: Bioluminescence imaging is routinely performed in anesthetized mice. Often isoflurane anesthesia is used because of its ease of use and fast induction/recovery. However, general anesthetics have been described as important inhibitors of t
Externí odkaz:
https://doaj.org/article/7600533215444eea85d42ab5c33fb97f
Autor:
Julie Heremans, Lucie Chevillard, Morgane Mannes, Jessica Mangialetto, Kaat Leroy, Jacinta F. White, Arthur Lamouroux, Mathieu Vinken, James Gardiner, Bruno Van Mele, Niko Van den Brande, Richard Hoogenboom, Annemieke Madder, Vicky Caveliers, Bruno Mégarbane, Sophie Hernot, Steven Ballet, Charlotte Martin
Publikováno v:
Journal of Controlled Release. 350:514-524
Peptide-based hydrogels represent promising systems for the sustained release of different types of drugs, ranging from small molecules to biologicals. Aiming at subcutaneous injection, which is a desirable parenteral administration route, especially