Zobrazeno 1 - 10
of 204
pro vyhledávání: '"Vickram Ramkumar"'
Autor:
Raheem F. H. Al Aameri, Entkhab M. A. Alanisi, Adu Oluwatosin, Dheyaa Al Sallami, Sandeep Sheth, Ian Alberts, Shree Patel, Leonard P. Rybak, Vickram Ramkumar
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Cisplatin is chemotherapy used for solid tumor treatment like lung, bladder, head and neck, ovarian and testicular cancers. However, cisplatin-induced ototoxicity limits the utility of this agent in cancer patients, especially when dose escalations a
Externí odkaz:
https://doaj.org/article/e5743741007e48a3a2bb4cfac44969d4
Autor:
Asmita Dhukhwa, Raheem F. H. Al Aameri, Sandeep Sheth, Debashree Mukherjea, Leonard Rybak, Vickram Ramkumar
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Regulators of G protein signaling (RGS) accelerate the GTPase activity of G proteins to enable rapid termination of the signals triggered by G protein-coupled receptors (GPCRs). Activation of several GPCRs, including cannabinoid receptor 2 (
Externí odkaz:
https://doaj.org/article/f7bd4bab02fb490bac2efed2eca9e9b6
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
It is well-known that aminoglycoside antibiotics can cause significant hearing loss and vestibular deficits that have been described in animal studies and in clinical reports. The purpose of this review is to summarize relevant preclinical and clinic
Externí odkaz:
https://doaj.org/article/ef8113005d2746c0a0cd70aabb6831f5
Publikováno v:
Antioxidants, Vol 10, Iss 12, p 1919 (2021)
Hearing loss is a significant health problem that can result from a variety of exogenous insults that generate oxidative stress and inflammation. This can produce cellular damage and impairment of hearing. Radiation damage, ageing, damage produced by
Externí odkaz:
https://doaj.org/article/3ceb9d2196c3417d9fa39fba55cef11b
Targeting Inflammatory Processes Mediated by TRPVI and TNF-α for Treating Noise-Induced Hearing Loss
Autor:
Asmita Dhukhwa, Puspanjali Bhatta, Sandeep Sheth, Krishi Korrapati, Coral Tieu, Chaitanya Mamillapalli, Vickram Ramkumar, Debashree Mukherjea
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Noise trauma is the most common cause of hearing loss in adults. There are no known FDA approved drugs for prevention or rescue of noise-induced hearing loss (NIHL). In this study, we provide evidence that implicates stress signaling molecules (TRPV1
Externí odkaz:
https://doaj.org/article/7e71ab38c76a4dbdb7ab28bf0757b6ef
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Systemic delivery of therapeutics for targeting the cochlea to prevent or treat hearing loss is challenging. Systemic drugs have to cross the blood-labyrinth barrier (BLB). BLB can significantly prevent effective penetration of drugs in appropriate c
Externí odkaz:
https://doaj.org/article/a3f8314e616541ac974e776ab9dce5d6
Publikováno v:
Cancer Research. 83:2564-2564
Introduction: Prostate cancer is the most prevalent cancer in American men with unknown etiology. Signal transducer and activator of transcription 3 (STAT3) is a transcription factor, which has been implicated in the growth and metastasis of prostate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4359aa33298dfaf2df3855108c25eb3
https://doi.org/10.1158/1538-7445.am2023-2564
https://doi.org/10.1158/1538-7445.am2023-2564
Autor:
Sumana Ghosh, Sandeep Sheth, Kelly Sheehan, Debashree Mukherjea, Asmita Dhukhwa, Vikrant Borse, Leonard P. Rybak, Vickram Ramkumar
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Previous studies have demonstrated the presence of cannabinoid 2 receptor (CB2R) in the rat cochlea which was induced by cisplatin. In an organ of Corti-derived cell culture model, it was also shown that an agonist of the CB2R protected these cells a
Externí odkaz:
https://doaj.org/article/eaafcb60df7f48dcb4f8ce600aeb7ae1
Akademický článek
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Publikováno v:
Frontiers in Cellular Neuroscience, Vol 11 (2017)
Evidence of significant hearing loss during the early days of use of cisplatin as a chemotherapeutic agent in cancer patients has stimulated research into the causes and treatment of this side effect. It has generally been accepted that hearing loss
Externí odkaz:
https://doaj.org/article/445b22c5bba74847871fc73444420e12