Structure, Conformation and Contact Analyses of Six Aromatic Diamide Diesters

Autor: Islam Ali Osman, Vickie McKee, Christian Jelsch, John F. Gallagher

Publikováno v: Crystals, Vol 13, Iss 7, p 1133 (2023)

Six meta-substituted isophthalamide diesters (DxE) and pyridinedicarboxamides (PxE) are reported with spectroscopic and crystal structure analyses (D = meta-C6H4; P = meta-pyridine; xE = 2-/3-/4-ethyl ester substitution). Comparisons are made between

Externí odkaz: https://doaj.org/article/90131b06cfd641839267ca745ed72b4a

Roles of Hydrogen, Halogen Bonding and Aromatic Stacking in a Series of Isophthalamides

Autor: Islam Ali Osman, Vickie McKee, Christian Jelsch, John F. Gallagher

Publikováno v: Symmetry, Vol 15, Iss 3, p 738 (2023)

The synthesis and spectroscopic characterisation of six bis(5-X-pyridine-2-yl)isophthalamides (X = H, F, Br, Cl, I, NO2) are reported, together with five crystal structure analyses (for X = H, F to I). The isophthalamides span a range of conformation

Externí odkaz: https://doaj.org/article/31499fe17a984b0da839e92ef574f3c9

Triggering autophagic cell death with a di-manganese(II) developmental therapeutic

Autor: Creina Slator, Zara Molphy, Vickie McKee, Andrew Kellett

Publikováno v: Redox Biology, Vol 12, Iss , Pp 150-161 (2017)

There is an unmet need for novel metal-based chemotherapeutics with alternative modes of action compared to clinical agents such as cisplatin and metallo-bleomycin. Recent attention in this field has focused on designing intracellular ROS-mediators a

Externí odkaz: https://doaj.org/article/fe3a5070ce47435fb16fdb4453cc2a38

X-Ray Crystallographic Analysis, EPR Studies, and Computational Calculations of a Cu(II) Tetramic Acid Complex

Autor: Dimitrios Matiadis, Dimitrios Tsironis, Valentina Stefanou, Olga Igglessi–Markopoulou, Vickie McKee, Yiannis Sanakis, Katerina N. Lazarou, Athanassios Chrissanthopoulos, Spyros N. Yannopoulos, John M. Markopoulos

Publikováno v: Bioinorganic Chemistry and Applications, Vol 2017 (2017)

In this work we present a structural and spectroscopic analysis of a copper(II) N-acetyl-5-arylidene tetramic acid by using both experimental and computational techniques. The crystal structure of the Cu(II) complex was determined by single crystal X

Externí odkaz: https://doaj.org/article/dd92052b411746d6aeeb29306c54b949

Development of Gene‐Targeted Polypyridyl Triplex‐Forming Oligonucleotide Hybrids

Autor: Bríonna McGorman, Daniel G. Singleton, Nicoló Zuin Fantoni, Andrew Kellett, Tom Brown, Sarah Walsh, Vickie McKee, Afaf H. El-Sagheer, Zara Molphy

Publikováno v: Zuin Fantoni, N, McGorman, B, Molphy, Z, Singleton, D, Walsh, S, El-Sagheer, A H, McKee, V, Brown, T & Kellett, A 2020, ' Development of Gene-Targeted Polypyridyl Triplex-Forming Oligonucleotide Hybrids ', ChemBioChem, vol. 21, no. 24, pp. 3563-3574 . https://doi.org/10.1002/cbic.202000408

In the field of nucleic acid therapy there is major interest in the development of libraries of DNA-reactive small molecules which are tethered to vectors that recognize and bind specific genes. This approach mimics enzymatic gene editors, such as ZF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae9849efc70e8f1c4424246c71e3562
https://doi.org/10.1002/cbic.202000408