Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Vicki S. Chambers"'
Autor:
Aleksandr B. Sahakyan, Vicki S. Chambers, Giovanni Marsico, Tobias Santner, Marco Di Antonio, Shankar Balasubramanian
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract We describe a sequence-based computational model to predict DNA G-quadruplex (G4) formation. The model was developed using large-scale machine learning from an extensive experimental G4-formation dataset, recently obtained for the human geno
Externí odkaz:
https://doaj.org/article/289341f558e943b6bbdbc39c89dcf616
Autor:
Giovanni, Marsico, Vicki S, Chambers, Aleksandr B, Sahakyan, Patrick, McCauley, Jonathan M, Boutell, Marco Di, Antonio, Shankar, Balasubramanian
Publikováno v:
Nucleic Acids Research
Genomic maps of DNA G-quadruplexes (G4s) can help elucidate the roles that these secondary structures play in various organisms. Herein, we employ an improved version of a G-quadruplex sequencing method (G4-seq) to generate whole genome G4 maps for 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4531abb63fb13c3459462175becfc585
https://pubmed.ncbi.nlm.nih.gov/30892612
https://pubmed.ncbi.nlm.nih.gov/30892612
Autor:
Marco Di Antonio, Anh Tuân Phan, Vicki S Chambers, Shankar Balasubramanian, Fernaldo Richtia Winnerdy, J Jeya Vandana, Anjali Sengar
Publikováno v:
Nucleic Acids Research
Poly (ADP-ribose) polymerase 1 (PARP1) has emerged as an attractive target for cancer therapy due to its key role in DNA repair processes. Inhibition of PARP1 in BRCA-mutated cancers has been observed to be clinically beneficial. Recent genome-mappin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c9fffa39920e963140da692c081e2c1
https://www.repository.cam.ac.uk/handle/1810/287386
https://www.repository.cam.ac.uk/handle/1810/287386
Autor:
Giovanni Marsico, Shankar Balasubramanian, Vicki S Chambers, Aleksandr B. Sahakyan, Chun Kit Kwok
Publikováno v:
Nature Methods. 13:841-844
We introduce RNA G-quadruplex sequencing (rG4-seq), a transcriptome-wide RNA G-quadruplex (rG4) profiling method that couples rG4-mediated reverse transcriptase stalling with next-generation sequencing. Using rG4-seq on polyadenylated-enriched HeLa R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa4b0d77571868a88d8add4131896695
https://doi.org/10.1038/nmeth.3965
https://doi.org/10.1038/nmeth.3965
Autor:
Giovanni Marsico, Shankar Balasubramanian, Vicki S Chambers, Geoffrey Paul Smith, Jonathan Mark Boutell, Marco Di Antonio
Publikováno v:
Nature Biotechnology. 33:877-881
G-quadruplexes (G4s) are nucleic acid secondary structures that form within guanine-rich DNA or RNA sequences. G4 formation can affect chromatin architecture and gene regulation and has been associated with genomic instability, genetic diseases and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aee31f4fac7295cfad65a96dfe271e6
https://doi.org/10.1038/nbt.3295
https://doi.org/10.1038/nbt.3295
Autor:
Chun Kit Kwok, Giovanni Marsico, Aleksandr B. Sahakyan, Vicki S. Chambers, Shankar Balasubramanian
Publikováno v:
Protocol Exchange.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1aca13a292ccf197fc98d142e648f26
https://doi.org/10.1038/protex.2016.060
https://doi.org/10.1038/protex.2016.060
Autor:
Tharin M. A. Blumenschein, James Tolchard, Vicki S. Chambers, Mark J. Banfield, Laurence S. Boutemy
Publikováno v:
Biophysical Journal. 104(2)
Plant diseases account for at least $220 billion of crop losses worldwide every year, and have a significant impact on global food security and bio-fuel availability. Bacterial, oomycetes and fungi pathogens secrete protein effectors into plant cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30388edbf1dedf73fa5d9a5e6b2647d6