ERK1/2 signalling dynamics promote neural differentiation by regulating chromatin accessibility and the polycomb repressive complex.

Autor: Claudia I Semprich, Lindsay Davidson, Adriana Amorim Torres, Harshil Patel, James Briscoe, Vicki Metzis, Kate G Storey

Publikováno v: PLoS Biology, Vol 20, Iss 12, p e3000221 (2022)

Fibroblast growth factor (FGF) is a neural inducer in many vertebrate embryos, but how it regulates chromatin organization to coordinate the activation of neural genes is unclear. Moreover, for differentiation to progress, FGF signalling must decline

Externí odkaz: https://doaj.org/article/31972082cebb403ea00c908b04efa953

Sox2 levels regulate the chromatin occupancy of WNT mediators in epiblast progenitors responsible for vertebrate body formation

Autor: Robert Blassberg, Harshil Patel, Thomas Watson, Mina Gouti, Vicki Metzis, M. Joaquina Delás, James Briscoe

WNT signalling has multiple roles. It maintains pluripotency of embryonic stem cells, assigns posterior identity in the epiblast and induces mesodermal tissue. Here we provide evidence that these distinct functions are conducted by the transcription

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::291f5a080aee8d8a0a05e40d55fcc675

Sox2 levels configure the WNT response of epiblast progenitors responsible for vertebrate body formation

Autor: James Briscoe, Mina Gouti, Thomas Watson, Vicki Metzis, Harshil Patel, Robert Blassberg, M. Joaquina Delás

WNT signalling has multiple roles. It maintains pluripotency of embryonic stem cells, assigns posterior identity in the epiblast and induces mesodermal tissue. We provide evidence that these distinct functions are conducted by the transcription facto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::667551394d6071a5341fa43078bf9cff
https://doi.org/10.1101/2020.12.29.424684

Precision of Tissue Patterning is Controlled by Dynamical Properties of Gene Regulatory Networks

Autor: Andreas Sagner, Katherine Exelby, James Briscoe, Peter Sollich, Lorena Garcia Perez, Vicki Metzis, Ruben Perez-Carrasco, Edgar Herrera-Delgado

Publikováno v: BioRxiv
bioRxiv
Development (Cambridge, England)
article-version (VoR) Version of Record
Exelby, K, Herrera-Delgado, E, Perez, L G, Perez-Carrasco, R, Sagner, A, Metzis, V, Sollich, P & Briscoe, J 2021, ' Precision of tissue patterning is controlled by dynamical properties of gene regulatory networks ', Development, vol. 148, no. 4, 197566 . https://doi.org/10.1242/dev.197566
Exelby, K, Herrera-Delgado, E, Perez, L G, Perez-Carrasco, R, Sagner, A, Metzis, V, Sollich, P & Briscoe, J 2021, ' Precision of tissue patterning is controlled by dynamical properties of gene regulatory networks ', Development (Cambridge, England), vol. 148, no. 4, dev197566 . https://doi.org/10.1242/dev.197566

During development, gene regulatory networks allocate cell fates by partitioning tissues into spatially organised domains of gene expression. How the sharp boundaries that delineate these gene expression patterns arise, despite the stochasticity asso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f909040dc24027ba75c6a4e4c4c0e13e

Regionalization of the nervous system requires axial allocation prior to neural lineage commitment

Autor: Edvinas Pakanavicius, James Briscoe, Sebastian Steinhauser, Nicholas M. Luscombe, Robin Lovell-Badge, Vicki Metzis, Despina Stamataki, Mina Gouti

SummaryNeural induction in vertebrates generates a central nervous system that extends the rostral-caudal length of the body. The prevailing view is that neural cells are initially induced with anterior (forebrain) identity, with caudalising signals

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21d77f3d97430c522b761343c05f5df9
http://edoc.mdc-berlin.de/17563/1/17563oa.pdf