Výsledky vyhledávání - "Vicki L. Coffin"

Cyclic urea derivatives as potent NK1 selective antagonists

Autor: Jean E. Lachowicz, Ruth A. Duffy, Ling Lin, Vicki L. Coffin, Neng-Yang Shih, Danlin Gu, Geoffrey B. Varty, Piwinski John J, Ho-Jane Shue, Cynthia A. Morgan, Gregory A. Reichard, David J. Blythin, John H. Schwerdt, Xiao Chen, Sapna S. Shah, Amin A. Nomeir, Sunil Paliwal, Fei Liu

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 15:3896-3899

A series of novel five- and six-membered ring urea derivatives have been described as potent and selective NK1 receptor antagonists. Several compounds in this series exhibited good oral activity and brain penetration. Syntheses of these compounds are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b04279394fe818201c58f792dfcd83df
https://doi.org/10.1016/j.bmcl.2005.05.111

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Metabolic stabilization of benzylidene ketal M2 muscarinic receptor antagonists via halonaphthoic acid substitution

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 11:2311-2314

The potential toxicological liabilities of the M(2) muscarinic antagonist 1 were addressed by replacing the methylenedioxyphenyl moiety with a p-methoxyphenyl group, resulting in M(2) selective compounds such as 3. Several halogenated naphthamide der

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4596ee0f6758218aaf4305ca38b8523f
https://doi.org/10.1016/s0960-894x(01)00435-8

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Muscarinic agonists and antagonists in the treatment of Alzheimer's disease

Publikováno v: Il Farmaco. 56:247-250

Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognitive impairment and personality changes. The development of drugs for the treatment of the cognitive deficits of AD has focused on agents which counteract loss in cholinerg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddc0fc1346ec5180de31419a16a4154d
https://doi.org/10.1016/s0014-827x(01)01102-8

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Effects of the dopamine D-1 antagonist SCH 23390 microinjected into the accumbens, amygdala or striatum on cocaine self-administration in the rat

Autor: George F. Koob, S B Caine, Stephen C. Heinrichs, Vicki L. Coffin

Publikováno v: Brain Research. 692:47-56

This study tested the hypothesis that blockade of D-1 dopamine receptors in the nucleus accumbens shell, central nucleus of the amygdala or dorsal striatum by intracerebral microinjection of the dopamine antagonist SCH 23390 produces an attenuation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be72140c189ced9b0aa6e55dbb7aa59d
https://doi.org/10.1016/0006-8993(95)00598-k

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Feibamate, a novel antiepileptic agent, does not affect cognition in rodents

Autor: R.D. Smith, Vicki L. Coffin, M.E. Grzelak

Publikováno v: Behavioural Pharmacology. 5:365-368

Felbamate is a novel anticonvulsant agent recently approved by the FDA for treatment of epilepsy in the US. While the mechanism of action of felbamate has not been fully eludicated, recent evidence has accumulated to suggest that felbamate may act at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a90dbcb685af4cb6c76b244414b112
https://doi.org/10.1097/00008877-199406000-00016

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In vivo binding to dopamine receptors: a correlate of potential antipsychotic activity

Autor: Robert D. McQuade, Allen Barnett, Vicki L. Coffin, Ruth A. Duffy

Publikováno v: European Journal of Pharmacology. 215:29-34

Antagonists of dopamine receptors (especially those of the D2 subtype) have long been recognized as effective antipsychotics. SCH 39166, a dopamine D1 selective antagonist, is now also being evaluated for its clinical antipsychotic properties. The st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::562023065ed0497de28bf7d381c5fb66
https://doi.org/10.1016/0014-2999(92)90604-3

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SCH 39166, a novel dopamine D1 receptor antagonist: In vitro investigation of its glucuronidation and potential species differences

Autor: Clark E. Tedford, Vilma Ruperto, Mary Cohen, Vicki L. Coffin, Allen Barnett, Michele Libonati

Publikováno v: Drug Development Research. 26:389-403

Tedford, C.E., V.B. Ruperto, V.L. Coffin, M. Cohen, M. Libonati, and A. Barnett: SCH 391 66, a novel dopamine D1 receptor antagonist: In vitro investigation of its glucuronidation and potential species differences. Drug Dev. Res. 26:389-403, 1992. SC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb18886f509c8f2e441c5e7ef888cba3
https://doi.org/10.1002/ddr.430260403

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Dopamine receptor binding properties of some 2,3,4,5-tetrahydro-1H-3-benzazepine-7-ols with non-aromatic substituents in the 5-position

Autor: Wei K. Chang, Vicki P. Fevig, Henry Guzik, Gouwei Zhou, Robert D. McQuade, Joel G. Berger, Vicki L. Coffin, Joseph A. Kozlowski, Marjorie Peters, Derek B. Lowe, Ruth A. Duffy

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 2:399-402

2,3,4,5-tetrahydro-1H-3-benzazepine-7-ols related to the selective dopamine D-1 antagonist SCH 23390, but bearing non-aromatic substituents in the 5-position possess considerable affinity and selectivity for D-1 vs. D-2 receptors.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a2d92bb02a456d6abe8fd8c6e45fc6e1
https://doi.org/10.1016/s0960-894x(00)80155-9

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