Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Vicki J. Swier"'
Autor:
Vicki J. Swier, Katherine A. White, Pedro L. Negrão de Assis, Tyler B. Johnson, Hannah G. Leppert, Mitchell J. Rechtzigel, David K. Meyerholz, Rebecca D. Dodd, Dawn E. Quelle, Rajesh Khanna, Christopher S. Rogers, Jill M. Weimer
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 6, Pp n/a-n/a (2024)
Abstract Cognitive or motor impairment is common among individuals with neurofibromatosis type 1 (NF1), an autosomal dominant tumor‐predisposition disorder. As many as 70% of children with NF1 report difficulties with spatial/working memory, attent
Externí odkaz:
https://doaj.org/article/dcb502b067bb4af5b36833c1c551cbde
Magnetic resonance brain volumetry biomarkers of CLN2 Batten disease identified with miniswine model
Autor:
Kevin Knoernschild, Hans J. Johnson, Kimberly E. Schroeder, Vicki J. Swier, Katherine A. White, Takashi S. Sato, Christopher S. Rogers, Jill M. Weimer, Jessica C. Sieren
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Late-infantile neuronal ceroid lipofuscinosis type 2 (CLN2) disease (Batten disease) is a rare pediatric disease, with symptom development leading to clinical diagnosis. Early diagnosis and effective tracking of disease progression are requi
Externí odkaz:
https://doaj.org/article/ae674f749002440bacb75763026cfd62
Autor:
Vicki J. Swier, Katherine A. White, Tyler B. Johnson, Xiaojun Wang, Jimin Han, David A. Pearce, Ruchira Singh, Arlene V. Drack, Wanda Pfeifer, Christopher S. Rogers, Jon J. Brudvig, Jill M. Weimer
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 8 (2023)
Externí odkaz:
https://doaj.org/article/3337fe76b208495abbbceb7bc70a4a23
Autor:
Jon J Brudvig, Vicki J Swier, Tyler B Johnson, Jacob C Cain, Melissa Pratt, Mitch Rechtzigel, Hannah Leppert, An N Dang Do, Forbes D Porter, Jill M Weimer
Publikováno v:
Biomarker Insights, Vol 17 (2022)
Introduction: CLN3 Batten disease is a rare pediatric neurodegenerative lysosomal disorder caused by biallelic disease-associated variants in CLN3. Despite decades of intense research, specific biofluid biomarkers of disease status have not been repo
Externí odkaz:
https://doaj.org/article/4ceddb055469419e823d73e1ebdf8514
Autor:
Vicki J Swier, Katherine A White, David K Meyerholz, Aude Chefdeville, Rajesh Khanna, Jessica C Sieren, Dawn E Quelle, Jill M Weimer
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0228222 (2020)
Genetically modified swine disease models are becoming increasingly important for studying molecular, physiological and pathological characteristics of human disorders. Given the limited history of these model systems, there remains a great need for
Externí odkaz:
https://doaj.org/article/e64e186dece145d8bb800f4b1cc4ecb8
Autor:
Palanikumar Gunasekar, Vicki J Swier, Jonathan P Fleegel, Chandra S Boosani, Mohamed M Radwan, Devendra K Agrawal
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0199411 (2018)
Vitamin D functions as a potent immunomodulator by interacting with many immune cells however, its role in regulating inflammation in the epicardial adipose tissue (EAT) is unclear. In the EAT of atherosclerotic microswine that were fed with deficien
Externí odkaz:
https://doaj.org/article/ed6db399f21f40889ea2f1da67c26524
Autor:
Vicki J. Swier, Katherine A. White, Tyler B. Johnson, Xiaojun Wang, Jimin Han, David A. Pearce, Ruchira Singh, Christopher S. Rogers, Jon J. Brudvig, Jill M. Weimer
Mouse models of CLN3 Batten disease, a rare lysosomal storage disorder with no cure, have improved our understanding of CLN3 biology and therapeutics through their ease of use and a consistent display of cellular pathology. However, the translatabili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbf9cdd0bcfca78f5514db3e08f0bc56
https://doi.org/10.1101/2022.10.07.511360
https://doi.org/10.1101/2022.10.07.511360
Autor:
Vicki J. Swier, Katherine A. White, Tyler B. Johnson, Jessica C. Sieren, Hans J. Johnson, Kevin Knoernschild, Xiaojun Wang, Frank A. Rohret, Christopher S. Rogers, David A. Pearce, Jon J. Brudvig, Jill M. Weimer
Publikováno v:
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 19(6)
CLN2 Batten disease is a lysosomal disorder in which pathogenic variants in CLN2 lead to reduced activity in the enzyme tripeptidyl peptidase 1. The disease typically manifests around 2 to 4 years of age with developmental delay, ataxia, seizures, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85856065d0195a2a598913fb2f94aaad
https://pubmed.ncbi.nlm.nih.gov/36100791
https://pubmed.ncbi.nlm.nih.gov/36100791
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147937 (2016)
Interventional procedures, including percutaneous transluminal coronary angioplasty (PTCA) and coronary artery bypass surgery (CABG) to re-vascularize occluded coronary arteries, injure the vascular wall and cause endothelial denudation and medial va
Externí odkaz:
https://doaj.org/article/f4b900f0adc5482493f4d1ef9bd9db79
Autor:
Vicki J Swier, Lin Tang, Kristopher D Krueger, Mohamed M Radwan, Michael G Del Core, Devendra K Agrawal
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138539 (2015)
Neointimal formation and cell proliferation resulting into in-stent restenosis is a major pathophysiological event following the deployment of stents in the coronary arteries. In this study, we assessed the degree of injury, based on damage to intern
Externí odkaz:
https://doaj.org/article/bcbbaf87775d49f68232c8a2e0f40bf8