Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Vicki E. Kelley"'
Publikováno v:
Journal of the American Society of Nephrology. 3:1972-1977
Autoimmune disease in mouse models of lupus nephritis is associated with enhanced renal tubular epithelial cell (TEC) expression of major histocompatibility complex (MHC) class II (Ia) molecules. It is unknown whether de novo TEC expression of syngen
Publikováno v:
Transplantation. 49:1150-1154
Although anti-CD3 mAb therapy is used extensively in clinical transplantation, the dose-related effects and mechanisms of action are not clearly defined. We have examined the dose-related effects of an antimurine CD3 mAb, 145-2C11, in pancreatic isle
Autor:
Vicki E. Kelley, Anthony M. Jevnikar, Rudolf P. Wuthrich, Mary A. Yui, Laurie H. Glimcher, Stephanie E. Dumas
Publikováno v:
Kidney International. 37:783-792
MHC class II, antigen presentation and tumor necrosis factor in renal tubular epithelial cells. Proximal tubular (PT) epithelial cells express MHC class II (la) antigens in immunologically-mediated renal injury. To study the role of PT as accessory c
Publikováno v:
Clinical immunology and immunopathology. 55(1)
T cell stimulation occurs following interaction of T cell receptor (TcR) with processed antigen presented by autologous accessory cells (AC). The effects of antigen stimulation on T cells are mimicked by monoclonal antibodies (Mabs) defining proteins
Autor:
Alan Winkelstein, Vicki E. Kelley
Publikováno v:
Clinical Immunology and Immunopathology. 17:212-218
In female NZB/W mice, PGE 1 has been shown to prolong survival and markedly reduce deposition of immune complexes in renal glomeruli. To further evaluate the pharmacological effects of this agent, lymphoid cellularity and the responses of spleen cell
Publikováno v:
European Journal of Immunology. 16:464-467
A recent report (Palacios, R., Eur. J. Immunol. 1984. 14: 599) indicates that spleen cells from MRL-MpJ-lpr/lpr mice spontaneously produce interleukin 3 (IL 3) and suggests that this lymphokine could be responsible for promoting the lymphoid hyperpla
Autor:
Jean C. Nichols, Terry B. Strom, Vicki E. Kelley, Patricia Bacha, John R. Murphy, Oleh Pankewycz
Publikováno v:
Proceedings of the National Academy of Sciences. 85:3980-3984
De novo expression of the interleukin 2 receptor (IL-2R) is a critical and pivotal event in initiation of an immune response. Targeting the low-affinity IL-2-binding p55 subunit of the high-affinity IL-2R with the rat anti-mouse IgM monoclonal antibo
Publikováno v:
Clinical Immunology and Immunopathology. 21:190-203
MRL 1 mice develop an autoimmune, lupus-like disorder characterized by massive proliferation of T cells and rapidly fatal immune complex nephritis. Prostaglandin E1 (PGE1), in pharmacologic quantities, retarded the development of this syndrome. The b
Publikováno v:
The Journal of Experimental Medicine
The effect of pharmacologic quantities of prostaglandin E1 (PGE) was investigated in three strains of mice (NZB X NZW, MRL/1, and BXSB) that spontaneously develop lupus-like glomerulonephritis. PGE-treatment prolonged survival and retarded the glomer
Autor:
Vicki E. Kelley, M. C. Vial, Jean Bariety, C. Bascou, Philippe Druet, Lucette Pelletier, Hinglais N, Catherine Sapin
Publikováno v:
Clinical Immunology and Immunopathology. 40:401-409
The effect of prostaglandin E1 on mercury-induced autoimmune disease in brown Norway rats has been investigated. Daily doses of 6 to 24 μg prolonged survival and significantly decreased proteinuria, deposition of immune reactants in the glomeruli, c