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Akademický článek

Aggregation and catabolism of disease-associated intra-Aβ mutations: reduced proteolysis of AβA21G by neprilysin

Autor: Vicki Betts, Malcolm A. Leissring, Georgia Dolios, Rong Wang, Dennis J. Selkoe, Dominic M. Walsh

Publikováno v: Neurobiology of Disease, Vol 31, Iss 3, Pp 442-450 (2008)

Five point mutations within the amyloid β-protein (Aβ) sequence of the APP gene are associated with hereditary diseases which are similar or identical to Alzheimer's disease and encode: the A21G (Flemish), E22G (Arctic), E22K (Italian), E22Q (Dutch

Externí odkaz: https://doaj.org/article/47d09018a227404694bb030ea20b80e0

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Akademický článek

Image-Based Treatment Planning of the Post-Lumpectomy Breast Utilizing CT and 3TMRI

Autor: Geraldine Jacobson, Gideon Zamba, Vicki Betts, M. Muruganandham, Joni Buechler-Price

Publikováno v: International Journal of Breast Cancer, Vol 2011 (2011)

Accurate lumpectomy cavity definition is critical in breast treatment planning. We compared contouring lumpectomy cavity volume and cavity visualization score (CVS) with CT versus 3T MRI. 29 patients were imaged with CT and 3T MRI. Seven additional b

Externí odkaz: https://doaj.org/article/2f1052303dce420d84c4daf9854d5314

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Aggregation and catabolism of disease-associated intra-Aβ mutations: reduced proteolysis of AβA21G by neprilysin

Autor: Malcolm A. Leissring, Georgia Dolios, Dennis J. Selkoe, Rong Wang, Vicki Betts, Dominic M. Walsh

Publikováno v: Neurobiology of Disease, Vol 31, Iss 3, Pp 442-450 (2008)

Five point mutations within the amyloid beta-protein (Abeta) sequence of the APP gene are associated with hereditary diseases which are similar or identical to Alzheimer's disease and encode: the A21G (Flemish), E22G (Arctic), E22K (Italian), E22Q (D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68b58cba7e60e2c45477a7dba5b01d64
https://doi.org/10.1016/j.nbd.2008.06.001

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Amyloid β Protein Dimer-Containing Human CSF Disrupts Synaptic Plasticity: Prevention by Systemic Passive Immunization

Autor: Roger Anwyl, Ying Peng, Thomas Wisniewski, William K. Cullen, Alfred T. Welzel, Michael J. Rowan, Henrik Zetterberg, Dennis J. Selkoe, Dominic M. Walsh, Igor Klyubin, Kaj Blennow, Cynthia A. Lemere, Vicki Betts, Anders Wallin

Publikováno v: The Journal of Neuroscience. 28:4231-4237

The current development of immunotherapy for Alzheimer's disease is based on the assumption that human-derived amyloid β protein (Aβ) can be targeted in a similar manner to animal cell-derived or synthetic Aβ. Because the structure of Aβ depends

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7a6ffe4274bcb426644e5eff0bea4c7
https://doi.org/10.1523/jneurosci.5161-07.2008

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Female Gender-specific Inhibition of KCNQ1 Channels and Chloride Secretion by 17β-Estradiol in Rat Distal Colonic Crypts

Autor: Mustapha Irnaten, Brian J. Harvey, Rodrigo Alzamora, Fiona O'Mahony, Franck LaPaix, Vicki Betts, Derek Carter

Publikováno v: Journal of Biological Chemistry. 282:24563-24573

The estrogen sex steroid 17beta-estradiol rapidly inhibits secretagogue-stimulated cAMP-dependent Cl(-) secretion in the female rat distal colonic crypt by the inhibition of basolateral K(+) channels. In Ussing chamber studies, both the anti-secretor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ac6ca6a41564bd1a96357a11d5ef9a
https://doi.org/10.1074/jbc.m611682200

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Amyloid β protein immunotherapy neutralizes Aβ oligomers that disrupt synaptic plasticity in vivo

Autor: Vicki Betts, Dennis J. Selkoe, Michael J. Rowan, Dominic M. Walsh, Igor Klyubin, William K. Cullen, Cynthia A. Lemere, Liying Jiang, Ganesh M. Shankar, Roger Anwyl, Edward T. Spooner

Publikováno v: Nature Medicine. 11:556-561

One of the most clinically advanced forms of experimental disease-modifying treatment for Alzheimer disease is immunization against the amyloid β protein (Aβ)1,2,3,4,5,6,7, but how this may prevent cognitive impairment is unclear8,9,10,11,12,13. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea76dee0c0f1267acef1a3a4a5571e4a
https://doi.org/10.1038/nm1234

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Direct Binding of Apoptosis Signal-regulating Kinase 1 to Retinoblastoma Protein

Autor: Srikumar Chellappan, Brenda Brennan, Dalia Ordonez-Ercan, Piyali Dasgupta, Bharat H. Joshi, Mark Morris, Shipra Rastogi, Vicki Betts

Publikováno v: Journal of Biological Chemistry. 279:38762-38769

The retinoblastoma protein Rb has antiproliferative and antiapoptotic functions. Our previous studies have shown that certain apoptotic signals can inactivate Rb via the p38 pathway. Here we show that Rb associates with the apoptosis signal-regulatin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ca095722b6645e50679517dc987c7ab
https://doi.org/10.1074/jbc.m312273200

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