Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Vickas V, Patel"'
Autor:
Christine K. Bailey, Stephen Caltabiano, Alexander R. Cobitz, Chun Huang, Kelly M. Mahar, Vickas V. Patel
Publikováno v:
BMC Nephrology, Vol 20, Iss 1, Pp 1-12 (2019)
Abstract Background Daprodustat is a hypoxia-inducible factor-prolyl hydroxylase inhibitor currently being investigated as a treatment for anemia of chronic kidney disease (CKD) in both dialysis and nondialysis patients. In clinical studies to date,
Externí odkaz:
https://doaj.org/article/27bc2670a74349538c5d727bfabca1f7
Autor:
Charli E. Harlow, Josan Gandawijaya, Rosemary A. Bamford, Emily-Rose Martin, Andrew R. Wood, Peter J. van der Most, Toshiko Tanaka, Hampton L. Leonard, Amy S. Etheridge, Federico Innocenti, Robin N. Beaumont, Jessica Tyrrell, Mike A. Nalls, Eleanor M. Simonsick, Pranav S. Garimella, Eric J. Shiroma, Niek Verweij, Peter van der Meer, Ron T. Gansevoort, Harold Snieder, Paul J. Gallins, Dereje D. Jima, Fred Wright, Yi-hui Zhou, Luigi Ferrucci, Stefania Bandinelli, Dena G. Hernandez, Pim van der Harst, Vickas V. Patel, Dawn M. Waterworth, Audrey Y. Chu, Asami Oguro-Ando, Timothy M. Frayling
Publikováno v:
American Journal of Human Genetics, 109(9), 1638-1652. CELL PRESS
Hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) are currently under clinical development for treating anemia in chronic kidney disease (CKD), but it is important to monitor their cardiovascular safety. Genetic variants can be used a
Autor:
Charli E Harlow, Vickas V Patel, Dawn M Waterworth, Andrew R Wood, Robin N Beaumont, Katherine S Ruth, Jessica Tyrrell, Asami Oguro-Ando, Audrey Y Chu, Timothy M Frayling
Publikováno v:
Human molecular genetics.
Prolyl hydroxylase (PHD) inhibitors are in clinical development for anaemia in chronic kidney disease. Epidemiological studies have reported conflicting results regarding safety of long-term therapeutic haemoglobin (Hgb) rises through PHD inhibition
Autor:
Alexander R. Cobitz, Christine K Bailey, Kelly M. Mahar, Vickas V. Patel, Stephen Caltabiano, Chun Huang
Publikováno v:
BMC Nephrology, Vol 20, Iss 1, Pp 1-12 (2019)
BMC Nephrology
BMC Nephrology
Background Daprodustat is a hypoxia-inducible factor-prolyl hydroxylase inhibitor currently being investigated as a treatment for anemia of chronic kidney disease (CKD) in both dialysis and nondialysis patients. In clinical studies to date, daprodust
Autor:
Vickas V. Patel, Bastiaan J. Boukens, Nataliya B. Petrenko, Michael J. Rust, Ozanna Burnicka-Turek, Kohta Ikegami, Ivan P. Moskowitz, Igor R. Efimov, Marcelo A. Nobrega, Jeffrey D. Steimle, Michael Broman, Xinan Yang
Publikováno v:
Circulation Research. 127
The heart beats 2 billion times over the average human lifespan and is the manifestation of a pattern of cardiomyocyte depolarization organized by a specialized network of cardiomyocytes, the cardiac conduction system (CCS). Patterning of the CCS int
Autor:
Rangarajan D. Nadadur, Xinan Yang, Vickas V. Patel, David E. Arnolds, Bastiaan J. Boukens, Nataliya B. Petrenko, Michael Broman, Kohta Ikegami, Ivan P. Moskowitz, Igor R. Efimov, Ozanna Burnicka-Turek, Marcelo A. Nobrega, Yun Qiao, Jeffrey D. Steimle
Publikováno v:
Circ Res
Circulation research, 127(3), E94-E106. Lippincott Williams and Wilkins
Circulation research, 127(3), E94-E106. Lippincott Williams and Wilkins
Rationale: The heartbeat is organized by the cardiac conduction system (CCS), a specialized network of cardiomyocytes. Patterning of the CCS into atrial node versus ventricular conduction system (VCS) components with distinct physiology is essential
Autor:
Jeffrey D. Steimle, Xinan Yang, Ozanna Burnicka-Turek, Yun Qiao, Vickas V. Patel, Rangarajan D Nadadaru, Ivan P. Moskowitz, Igor R. Efimov, David E. Arnolds, Marcelo A. Nobrega, Michael J. Rust, Bastiaan J. Boukens, Kohta Ikegami, Michael Broman
Publikováno v:
Circulation. 138
Autor:
Wei-Chung Tsai, Vickas V. Patel, Maria Kudela, Thomas H. Everett, Peng Sheng Chen, Po-Cheng Chang, Zhenhui Chen, Dhanendra Tomar, Changyu Shen, Yi Hsin Chan, Chia Hsiang Hsueh, Eue Keun Choi, Nicholas Anzalone, Michael A. Olaopa, Michael Rubart-von der Lohe, Shien-Fong Lin, Pooja Jadiya, Emily Luvison
Publikováno v:
Heart Rhythm. 13:1527-1535
Background The melanin synthesis enzyme dopachrome tautomerase (Dct) regulates intracellular Ca 2+ in melanocytes. Homozygous Dct knockout (Dct −/− ) adult mice are vulnerable to atrial arrhythmias (AA). Objective The purpose of this study was to
Autor:
E. Kevin Heist, Alan Cheng, Moussa Mansour, Abhishek Maan, Jeremy N. Ruskin, Vickas V. Patel, Marwan M. Refaat, Elad Anter
Publikováno v:
Critical Pathways in Cardiology: A Journal of Evidence-Based Medicine. 14:81-85
Obstructive sleep apnea (OSA) is increasingly recognized as an important risk factor for arrhythmogenesis. Epidemiological and clinical studies have suggested a strong association between OSA and atrial fibrillation (AF). With the increasing global e
Autor:
Francis E. Marchlinski, Mouhannad M. Sadek, Gregory E. Supple, Mathew D. Hutchinson, David J. Callans, Lidia Carballeira, Rupa Bala, Vickas V. Patel, Daniel Benhayon, Pasquale Santangeli, Erica S. Zado, William Chik, Ravi Sureddi, Fermin C. Garcia
Publikováno v:
Heart Rhythm. 12:67-75
Background The moderator band (MB) can be a source of premature ventricular contractions (PVCs), monomorphic ventricular tachycardia (VT), and idiopathic ventricular fibrillation (IVF). Objective The purpose of this study was to define the electrocar