Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Vichithra R B Liyanage"'
Autor:
Carl O Olson, Robby M Zachariah, Chinelo D Ezeonwuka, Vichithra R B Liyanage, Mojgan Rastegar
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90645 (2014)
MeCP2 is a critical epigenetic regulator in brain and its abnormal expression or compromised function leads to a spectrum of neurological disorders including Rett Syndrome and autism. Altered expression of the two MeCP2 isoforms, MeCP2E1 and MeCP2E2
Externí odkaz:
https://doaj.org/article/047f4ba6b42345e188dbaa95e4f78880
Autor:
Carl O. Olson, Robby M. Zachariah, Geoffrey G. Hicks, Wayne Xu, Romina D. Levy, Aaron MacAulay, James R. Davie, Kyle Curtis, Marjorie Buist, Shayan Amiri, Mojgan Rastegar, Vichithra R. B. Liyanage
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)
Scientific Reports
Scientific Reports
We have previously reported the deregulatory impact of ethanol on global DNA methylation of brain-derived neural stem cells (NSC). Here, we conducted a genome-wide RNA-seq analysis in differentiating NSC exposed to different modes of ethanol exposure
Publikováno v:
International Journal of Molecular Sciences
Methyl CpG binding protein-2 (MeCP2) isoforms (E1 and E2) are important epigenetic regulators in brain cells. Accordingly, MeCP2 loss- or gain-of-function mutation causes neurodevelopmental disorders, including Rett syndrome (RTT), MECP2 duplication
Autor:
Nanditha Murugeshan, Marc R. Del Bigio, Vichithra R. B. Liyanage, Mojgan Rastegar, James R. Davie, Jessica S. Jarmasz
Publikováno v:
Biology, Vol 3, Iss 4, Pp 670-723 (2014)
Biology
Biology
Epigenetics refers to a variety of processes that have heritable effects on gene expression programs without changes in DNA sequence. Key players in epigenetic control are chemical modifications to DNA, histone, and non-histone chromosomal proteins,
Autor:
Geneviève P. Delcuve, Mojgan Rastegar, Vichithra R. B. Liyanage, Dilshad H. Khan, James R. Davie, Sanzida Jahan, Lorrie A. Kirshenbaum
Publikováno v:
Epigenetics in Cardiac Disease ISBN: 9783319414553
Epigenetics refer to processes such as histone post-translational modifications (PTMs), DNA methylation and RNA that regulate gene activity and expression but are not dependent on alterations in DNA sequence. Herein, we review histone PTMs, histone v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eee2af214d5c38bbc7793e24c06833fc
https://doi.org/10.1007/978-3-319-41457-7_1
https://doi.org/10.1007/978-3-319-41457-7_1
Autor:
Robby M. Zachariah, Vichithra R. B. Liyanage, Albert E. Chudley, Kyle Curtis, Mojgan Rastegar
Publikováno v:
Current topics in medicinal chemistry. 17(7)
Prenatal alcohol (ethanol) exposure (PAE) is the underlying cause for a variety of birth defects and neurodevelopmental deficits referred to as “Fetal Alcohol Spectrum Disorders (FASD)”. The more visible phenotypes caused by PAE include growth re
Publikováno v:
Experimental neurology. 265
Methyl CpG Binding Protein 2 (MeCP2) is an important epigenetic factor in the brain. MeCP2 expression is affected by different environmental insults including alcohol exposure. Accumulating evidence supports the role of aberrant MeCP2 expression in e
Publikováno v:
Neuromolecular medicine. 16(2)
Rett syndrome (RTT) is a severe and progressive neurological disorder, which mainly affects young females. Mutations of the methyl-CpG binding protein 2 (MECP2) gene are the most prevalent cause of classical RTT cases. MECP2 mutations or altered expr
Publikováno v:
Molecular Autism
Background Aberrant MeCP2 expression in brain is associated with neurodevelopmental disorders including autism. In the brain of stressed mouse and autistic human patients, reduced MeCP2 expression is correlated with Mecp2/MECP2 promoter hypermethylat
Autor:
Vichithra R. B. Liyanage, Benjamin A. Barber, Carl O. Olson, Robby M. Zachariah, Melissa A.G. Bailey, Mojgan Rastegar
Publikováno v:
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. 195(5)
Central nervous system development is controlled by highly conserved homeoprotein transcription factors including HOX and TALE (Three Amino acid Loop Extension). TALE proteins are primarily known as HOX-cofactors and play key roles in cell proliferat