CartoCell, a high-content pipeline for 3D image analysis, unveils cell morphology patterns in epithelia

Autor: Jesús A. Andrés-San Román, Carmen Gordillo-Vázquez, Daniel Franco-Barranco, Laura Morato, Cecilia H. Fernández-Espartero, Gabriel Baonza, Antonio Tagua, Pablo Vicente-Munuera, Ana M. Palacios, María P. Gavilán, Fernando Martín-Belmonte, Valentina Annese, Pedro Gómez-Gálvez, Ignacio Arganda-Carreras, Luis M. Escudero

Publikováno v: Cell Reports: Methods, Vol 3, Iss 10, Pp 100597- (2023)

Summary: Decades of research have not yet fully explained the mechanisms of epithelial self-organization and 3D packing. Single-cell analysis of large 3D epithelial libraries is crucial for understanding the assembly and function of whole tissues. Co

Externí odkaz: https://doaj.org/article/ec2af9bd96934499a42ff5a2dff1b23c

Non-productive angiogenesis disassembles Aß plaque-associated blood vessels

Autor: Maria I. Alvarez-Vergara, Alicia E. Rosales-Nieves, Rosana March-Diaz, Guiomar Rodriguez-Perinan, Nieves Lara-Ureña, Clara Ortega-de San Luis, Manuel A. Sanchez-Garcia, Miguel Martin-Bornez, Pedro Gómez-Gálvez, Pablo Vicente-Munuera, Beatriz Fernandez-Gomez, Miguel A. Marchena, Andrea S. Bullones-Bolanos, Jose C. Davila, Rocio Gonzalez-Martinez, Jose L. Trillo-Contreras, Ana C. Sanchez-Hidalgo, Raquel del Toro, Francisco G. Scholl, Eloisa Herrera, Martin Trepel, Jakob Körbelin, Luis M. Escudero, Javier Villadiego, Miriam Echevarria, Fernando de Castro, Antonia Gutierrez, Alberto Rabano, Javier Vitorica, Alberto Pascual

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

Aß are extracellular deposits relevant in Alzheimer’s disease (AD). This study shows that Aß plaques are hubs of endothelial disassembly that induce non-productive angiogenesis. This process is aided by the microglia and unchained by reduced pres

Externí odkaz: https://doaj.org/article/65297e3308ba45ef8cbc879a7f19dfe0

Evolutionary 3D Image Segmentation of Curve Epithelial Tissues of Drosophila melanogaster

Autor: Carlos Capitán-Agudo, Beatriz Pontes, Pedro Gómez-Gálvez, Pablo Vicente-Munuera

Publikováno v: Applied Sciences, Vol 11, Iss 14, p 6410 (2021)

Analysing biological images coming from the microscope is challenging; not only is it complex to acquire the images, but also the three-dimensional shapes found on them. Thus, using automatic approaches that could learn and embrace that variance woul

Externí odkaz: https://doaj.org/article/7263095bea1f44a294c3ec877c940f7d

Author Correction: Scutoids are a geometrical solution to three-dimensional packing of epithelia

Autor: Pedro Gómez-Gálvez, Pablo Vicente-Munuera, Antonio Tagua, Cristina Forja, Ana M. Castro, Marta Letrán, Andrea Valencia-Expósito, Clara Grima, Marina Bermúdez-Gallardo, Óscar Serrano-Pérez-Higueras, Florencia Cavodeassi, Sol Sotillos, María D. Martín-Bermudo, Alberto Márquez, Javier Buceta, Luis M. Escudero

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)

The original version of this Article contained an error in ref. 39, which incorrectly cited ‘Fristrom, D. & Fristrom, J. W. in The Development of Drosophila melanogaster (eds. Bate, M. & Martinez-Arias, A.) II, (Cold spring harbor laboratory press,

Externí odkaz: https://doaj.org/article/856cbd900ed94315bcc7301f0012e931

Non-productive angiogenesis disassembles A ss plaque-associated blood vessels

Autor: Alvarez-Vergara M, Rosales-Nieves A, March-Diaz R, Rodriguez-Perinan G, Lara-Urena N, San Luis C, Sanchez-Garcia M, Martin-Bornez M, Gomez-Galvez P, Vicente-Munuera P, Fernandez-Gomez B, Marchena M, Bullones-Bolanos A, Davila J, Gonzalez-Martinez R, Trillo-Contreras J, Sanchez-Hidalgo A, del Toro R, Scholl F, Herrera E, Trepel M, Korbelin J, Escudero L, Villadiego J, Echevarria M, de Castro F, Gutierrez A, Rabano A, Vitorica J, Pascual A

Publikováno v: NATURE COMMUNICATIONS
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
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The human Alzheimer's disease (AD) brain accumulates angiogenic markers but paradoxically, the cerebral microvasculature is reduced around A ss plaques. Here we demonstrate that angiogenesis is started near A ss plaques in both AD mouse models and hu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::82e8c0df034ef689b954221e24dbe8bc
https://fundanet.isabial.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=8650