Comparative assessment of a COVID-19 vaccine after technology transfer to Iran from critical quality attributes to clinical and immunogenicity aspects

Autor: Delaram Doroud, Mona Sadat Larijani, Alireza Biglari, Fatemeh Ashrafian, Talieh Sabouni, Sana Eybpoosh, Vicente Verez-Bencomo, Yury Valdés-Balbín, Dagmar García-Rivera, Yaneli Herrera-Rojas, Yanet Climent-Ruiz, Darielys Santana-Mederos, Amitis Ramezani

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)

Abstract During COVID-19 pandemic, international pharmaceutical companies put effort to build global manufacturing networks for vaccines. Soberana Plus vaccine, a recombinant protein based vaccine (RBD dimer), with the trade name of PastoCovac Plus i

Externí odkaz: https://doaj.org/article/ad6a9e1b41334add9fc1681433e0005c

Evaluation of PastoCovac plus vaccine as a booster dose on vaccinated individuals with inactivated COVID-19 vaccine

Autor: Behrokh Farahmand, Mona Sadat Larijani, Fatemeh Fotouhi, Alireza Biglari, Rahim Sorouri, Fahimeh Bagheri Amiri, Ali Eslamifar, Tahmineh Jalali, Mostafa Salehi-Vaziri, Mohammad Banifazl, Sarah Dahmardeh, Azita Eshratkhah Mohammadnejad, Anahita Bavand, Mahsa Tavakoli, Vicente Verez-Bencomo, Ehsan Mostafavi, Hassan Noori Daloii, Fatemeh Ashrafian, Masoumeh Saberpour, Amitis Ramezani

Publikováno v: Heliyon, Vol 9, Iss 10, Pp e20555- (2023)

COVID-19 pandemic has been managed through global vaccination programs. However, the antibody waning in various types of vaccines came to notice. Hereby, PastoCovac Plus as a protein subunit vaccine was investigated in immunized health care workers b

Externí odkaz: https://doaj.org/article/648d691f633e440b90bb0a37d594a11f

Molecular Aspects Concerning the Use of the SARS-CoV‑2 Receptor Binding Domain as a Target for Preventive Vaccines

Autor: Yury Valdes-Balbin, Darielys Santana-Mederos, Françoise Paquet, Sonsire Fernandez, Yanet Climent, Fabrizio Chiodo, Laura Rodríguez, Belinda Sanchez Ramirez, Kalet Leon, Tays Hernandez, Lila Castellanos-Serra, Raine Garrido, Guang-Wu Chen, Dagmar Garcia-Rivera, Daniel G. Rivera, Vicente Verez-Bencomo

Publikováno v: ACS Central Science, Vol 7, Iss 5, Pp 757-767 (2021)

Externí odkaz: https://doaj.org/article/f985a93b2bbb451db45714c249cf4eea

A randomized, double-blind phase I clinical trial of two recombinant dimeric RBD COVID-19 vaccine candidates: Safety, reactogenicity and immunogenicity

Autor: Franciscary Pi-Estopinan, Jorman Rubino-Moreno, Mayte Amoroto-Roig, Maria Teresa Perez-Guevara, Yury Valdés-Balbín, Laura M. Rodríguez-Noda, Marisel Martinez-Perez, Meiby de la Caridad Rodriguez-Gonzalez, Carmen M Valenzuela-Silva, Dagmar García-Rivera, Rolando Ochoa-Azze, Maura Tamayo-Rodriguez, Raul Gonzalez-Mugica, Vicente Verez-Bencomo, Yanet Chappi-Estevez, Yanet Climent-Ruiz, Belinda Sanchez-Ramirez, Beatriz Paredes-Moreno, Anamary Suarez-Batista, Gretchen Bergado-Baez, Tays Hernandez-Garcia, Alina Díaz-Machado, Alis Martín-Trujillo, Sonia Pérez-Rodríguez, Rocmira Perez-Nicado, Guang-Wu Chen, Marta Dubed-Echevarría, Carlos A. González-Delgado

Publikováno v: Vaccine. 40:2068-2075

BackgroundThe Receptor Binding Domain (RBD) of the SARS-CoV-2 spike protein is the target for many COVID-19 vaccines. Here we report results for phase 1 clinical trial of two COVID-19 vaccine candidates based on recombinant dimeric RBD (d-RBD).Method

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b445b9be96c36bcec3631c8577e62bff
https://doi.org/10.1016/j.vaccine.2022.02.029

In-solution buffer-free digestion allows full-sequence coverage and complete characterization of post-translational modifications of the receptor-binding domain of SARS-CoV-2 in a single ESI–MS spectrum

Autor: Gertrudis Rojas, Yury Valdés-Balbín, Dayana Pérez-Martínez, Vicente Verez-Bencomo, Sum Lai Lozada Chang, Isabel González, Ivan Andújar, Daniel G. Rivera, Enso Onill Torres, Luis Javier González, Gleysin Cabrera, Darielys Santana-Medero, Marika Vitikainen, Julio Palacio, Mark Emalfarb, Marta Ayala, Camila Canaán-Haden, Diamilé Roche, Lourdes Hernández, Vladimir Besada, Saloheimo Markku, Mónica Becquet, Glay Chinea, Eulogio Pimentel, Elías Nelson, Yassel Ramos, Luis Ariel Espinosa, Gerardo Guillén, Kathya Rashida de la Luz Hernández, Tamy Boggiano, Beatriz Pérez-Massón, Miladys Limonta, Alejandro Martín, Ronen Tchelet

Publikováno v: Espinosa, L A, Ramos, Y, Andújar, I, Torres, E O, Cabrera, G, Martín, A, Roche, D, Chinea, G, Becquet, M, González, I, Canaán-Haden, C, Nelson, E, Rojas, G, Pérez-Massón, B, Pérez-Martínez, D, Boggiano, T, Palacio, J, Lozada Chang, S L, Hernández, L, de la Luz Hernández, K R, Markku, S, Vitikainen, M, Valdés-Balbín, Y, Santana-Medero, D, Rivera, D G, Vérez-Bencomo, V, Emalfarb, M, Tchelet, R, Guillén, G, Limonta, M, Pimentel, E, Ayala, M, Besada, V & González, L J 2021, ' In-solution buffer-free digestion allows full-sequence coverage and complete characterization of post-translational modifications of the receptor-binding domain of SARS-CoV-2 in a single ESI–MS spectrum ', Analytical and Bioanalytical Chemistry, vol. 413, no. 30, pp. 7559-7585 . https://doi.org/10.1007/s00216-021-03721-w
Analytical and Bioanalytical Chemistry

Subunit vaccines based on the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2 provide one of the most promising strategies to fight the COVID-19 pandemic. The detailed characterization of the protein primary structure by mass spectro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a152c916511b98ca4c2e2db9258c9d7
https://cris.vtt.fi/en/publications/3a525b22-9b0f-4e75-afdb-cb7866f4d80e