Evaluation of PastoCovac plus vaccine as a booster dose on vaccinated individuals with inactivated COVID-19 vaccine

Autor: Behrokh Farahmand, Mona Sadat Larijani, Fatemeh Fotouhi, Alireza Biglari, Rahim Sorouri, Fahimeh Bagheri Amiri, Ali Eslamifar, Tahmineh Jalali, Mostafa Salehi-Vaziri, Mohammad Banifazl, Sarah Dahmardeh, Azita Eshratkhah Mohammadnejad, Anahita Bavand, Mahsa Tavakoli, Vicente Verez-Bencomo, Ehsan Mostafavi, Hassan Noori Daloii, Fatemeh Ashrafian, Masoumeh Saberpour, Amitis Ramezani

Publikováno v: Heliyon, Vol 9, Iss 10, Pp e20555- (2023)

COVID-19 pandemic has been managed through global vaccination programs. However, the antibody waning in various types of vaccines came to notice. Hereby, PastoCovac Plus as a protein subunit vaccine was investigated in immunized health care workers b

Externí odkaz: https://doaj.org/article/648d691f633e440b90bb0a37d594a11f

Molecular Aspects Concerning the Use of the SARS-CoV‑2 Receptor Binding Domain as a Target for Preventive Vaccines

Autor: Yury Valdes-Balbin, Darielys Santana-Mederos, Françoise Paquet, Sonsire Fernandez, Yanet Climent, Fabrizio Chiodo, Laura Rodríguez, Belinda Sanchez Ramirez, Kalet Leon, Tays Hernandez, Lila Castellanos-Serra, Raine Garrido, Guang-Wu Chen, Dagmar Garcia-Rivera, Daniel G. Rivera, Vicente Verez-Bencomo

Publikováno v: ACS Central Science, Vol 7, Iss 5, Pp 757-767 (2021)

Externí odkaz: https://doaj.org/article/f985a93b2bbb451db45714c249cf4eea

A randomized, double-blind phase I clinical trial of two recombinant dimeric RBD COVID-19 vaccine candidates: Safety, reactogenicity and immunogenicity

Autor: Franciscary Pi-Estopinan, Jorman Rubino-Moreno, Mayte Amoroto-Roig, Maria Teresa Perez-Guevara, Yury Valdés-Balbín, Laura M. Rodríguez-Noda, Marisel Martinez-Perez, Meiby de la Caridad Rodriguez-Gonzalez, Carmen M Valenzuela-Silva, Dagmar García-Rivera, Rolando Ochoa-Azze, Maura Tamayo-Rodriguez, Raul Gonzalez-Mugica, Vicente Verez-Bencomo, Yanet Chappi-Estevez, Yanet Climent-Ruiz, Belinda Sanchez-Ramirez, Beatriz Paredes-Moreno, Anamary Suarez-Batista, Gretchen Bergado-Baez, Tays Hernandez-Garcia, Alina Díaz-Machado, Alis Martín-Trujillo, Sonia Pérez-Rodríguez, Rocmira Perez-Nicado, Guang-Wu Chen, Marta Dubed-Echevarría, Carlos A. González-Delgado

Publikováno v: Vaccine. 40:2068-2075

BackgroundThe Receptor Binding Domain (RBD) of the SARS-CoV-2 spike protein is the target for many COVID-19 vaccines. Here we report results for phase 1 clinical trial of two COVID-19 vaccine candidates based on recombinant dimeric RBD (d-RBD).Method

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b445b9be96c36bcec3631c8577e62bff
https://doi.org/10.1016/j.vaccine.2022.02.029

In-solution buffer-free digestion allows full-sequence coverage and complete characterization of post-translational modifications of the receptor-binding domain of SARS-CoV-2 in a single ESI–MS spectrum

Autor: Gertrudis Rojas, Yury Valdés-Balbín, Dayana Pérez-Martínez, Vicente Verez-Bencomo, Sum Lai Lozada Chang, Isabel González, Ivan Andújar, Daniel G. Rivera, Enso Onill Torres, Luis Javier González, Gleysin Cabrera, Darielys Santana-Medero, Marika Vitikainen, Julio Palacio, Mark Emalfarb, Marta Ayala, Camila Canaán-Haden, Diamilé Roche, Lourdes Hernández, Vladimir Besada, Saloheimo Markku, Mónica Becquet, Glay Chinea, Eulogio Pimentel, Elías Nelson, Yassel Ramos, Luis Ariel Espinosa, Gerardo Guillén, Kathya Rashida de la Luz Hernández, Tamy Boggiano, Beatriz Pérez-Massón, Miladys Limonta, Alejandro Martín, Ronen Tchelet

Publikováno v: Espinosa, L A, Ramos, Y, Andújar, I, Torres, E O, Cabrera, G, Martín, A, Roche, D, Chinea, G, Becquet, M, González, I, Canaán-Haden, C, Nelson, E, Rojas, G, Pérez-Massón, B, Pérez-Martínez, D, Boggiano, T, Palacio, J, Lozada Chang, S L, Hernández, L, de la Luz Hernández, K R, Markku, S, Vitikainen, M, Valdés-Balbín, Y, Santana-Medero, D, Rivera, D G, Vérez-Bencomo, V, Emalfarb, M, Tchelet, R, Guillén, G, Limonta, M, Pimentel, E, Ayala, M, Besada, V & González, L J 2021, ' In-solution buffer-free digestion allows full-sequence coverage and complete characterization of post-translational modifications of the receptor-binding domain of SARS-CoV-2 in a single ESI–MS spectrum ', Analytical and Bioanalytical Chemistry, vol. 413, no. 30, pp. 7559-7585 . https://doi.org/10.1007/s00216-021-03721-w
Analytical and Bioanalytical Chemistry

Subunit vaccines based on the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2 provide one of the most promising strategies to fight the COVID-19 pandemic. The detailed characterization of the protein primary structure by mass spectro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a152c916511b98ca4c2e2db9258c9d7
https://cris.vtt.fi/en/publications/3a525b22-9b0f-4e75-afdb-cb7866f4d80e

Expanding the Scope of Ugi Multicomponent Bioconjugation to Produce Pneumococcal Multivalent Glycoconjugates as Vaccine Candidates

Autor: Raine Garrido, Mirelys Saenz, Yanira Méndez, Vicente Verez-Bencomo, Rocmira Perez-Nicado, Daniel G. Rivera, Ana R. Humpierre, Aldrin V. Vasco, Dagmar García-Rivera, Abel Zanuy, Yamilka Soroa-Milán, Bernhard Westermann, Darielys Santana-Mederos

Publikováno v: Bioconjugate Chemistry. 31:2231-2240

Conjugate vaccines against encapsulated pathogens like Streptococcus pneumoniae face many challenges, including the existence of multiple serotypes with a diverse global distribution that constantly requires new formulations and higher coverage. Mult

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5460607915493e2b4a4e6cc4778c7d8
https://doi.org/10.1021/acs.bioconjchem.0c00423