Increased levels of anti-PfCSP antibodies in post-pubertal females versus males immunized with PfSPZ Vaccine does not translate into increased protective efficacy

Autor: Natasha KC, L. W. Preston Church, Pouria Riyahi, Sumana Chakravarty, Robert A. Seder, Judith E. Epstein, Kirsten E. Lyke, Benjamin Mordmüller, Peter G. Kremsner, Mahamadou S. Sissoko, Sara Healy, Patrick E. Duffy, Said A. Jongo, Vicente Urbano Nsue Ndong Nchama, Salim Abdulla, Maxmillian Mpina, Sodiomon B. Sirima, Matthew B. Laurens, Laura C. Steinhardt, Martina Oneko, MingLin Li, Tooba Murshedkar, Peter F. Billingsley, B. Kim Lee Sim, Thomas L. Richie, Stephen L. Hoffman

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

BackgroundWhile prior research has shown differences in the risk of malaria infection and sickness between males and females, little is known about sex differences in vaccine-induced immunity to malaria. Identifying such differences could elucidate i

Externí odkaz: https://doaj.org/article/d6334f1741f1482b91e5bb9239e66e76

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Incidence of Plasmodium falciparum malaria infection in 6-month to 45-year-olds on selected areas of Bioko Island, Equatorial Guinea.

Autor: Nchama, Vicente Urbano Nsue Ndong^1,2 (AUTHOR), Said, Ali Hamad^2,3 (AUTHOR) ahamad@ihi.or.tz, Mtoro, Ali^2,3 (AUTHOR), Bidjimi, Gertrudis Owono^1,2 (AUTHOR), Owono, Marta Alene^1,2 (AUTHOR), Maye, Escolastica Raquel Mansogo^1,2 (AUTHOR), Mangue, Martin Eka Ondo^1,2 (AUTHOR), Okomo, Genaro Nsue Nguema^1,2 (AUTHOR), Pasialo, Beltran Ekua Ntutumu^1,2 (AUTHOR), Ondo, Dolores Mbang^1,2 (AUTHOR), Lopez, Maria-Silvia Angue^1,2 (AUTHOR), Mochomuemue, Fortunata Lobede^1,2 (AUTHOR), Obono, Mariano Obiang^1,2 (AUTHOR), Besaha, Juan Carlos Momo^1,2 (AUTHOR), Chuquiyauri, Raul^2,4 (AUTHOR), Jongo, Said Abdallah² (AUTHOR), Kamaka, Kassim^2,3 (AUTHOR), Kibondo, Ummi Abdul³ (AUTHOR), Athuman, Thabit³ (AUTHOR), Falla, Carlos Cortez² (AUTHOR)

Publikováno v: Malaria Journal. 7/20/2021, Vol. 20 Issue 1, p1-13. 13p.

Incidence of Plasmodium falciparum malaria infection in 6-month to 45-year-olds on selected areas of Bioko Island, Equatorial Guinea

Autor: Ali Hamad Said, Martin Eka Ondo Mangue, Kassim Kamaka, Genaro Nsue Nguema Okomo, Ali Mtoro, Escolastica Raquel Mansogo Maye, Laurence Lemiale, Ally Olotu, Thabit Athuman, Carlos Cortez Falla, Peter F. Billingsley, Salim Abdulla, Vicente Urbano Nsue Ndong Nchama, Jeremías Nzamio Mba Eyono, Mariano Obiang Obono, Stephen L. Hoffman, Marcel Tanner, L. W. Preston Church, Gertrudis Owono Bidjimi, Tobias Schindler, B. Kim Lee Sim, Dolores Mbang Ondo, José Raso, Fortunata Lobede Mochomuemue, Juan Carlos Momo Besaha, Maxmillian Mpina, Thomas L. Richie, Claudia Daubenberger, Guillermo A. García, Raul Chuquiyauri, Beltran Ekua Ntutumu Pasialo, Said Abdallah Jongo, Marta Alene Owono, Maria-Silvia Angue Lopez, Elizabeth Nyakarungu, Jordan Smith, Ummi Abdul Kibondo

Publikováno v: Malaria Journal, Vol 20, Iss 1, Pp 1-13 (2021)
Malaria Journal

Background Extensive malaria control measures have been implemented on Bioko Island, Equatorial Guinea over the past 16 years, reducing parasite prevalence and malaria-related morbidity and mortality, but without achieving elimination. Malaria vaccin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47302cfcdde102aeb282861727992023
https://doaj.org/article/3e7774f81b3642fb8979372514e81536

Multi-Dose Priming Regimens of PfSPZ Vaccine: Safety and Efficacy against Controlled Human Malaria Infection in Equatoguinean Adults

Autor: Said Abdallah Jongo, L. W. Preston Church, Vicente Urbano Nsue Ndong Nchama, Ali Hamad, Raul Chuquiyauri, Kamaka Ramadhani Kassim, Thabit Athuman, Anna Deal, KC Natasha, Ali Mtoro, Maxmillian Mpina, Elizabeth Nyakarungu, Gertrudis Owono Bidjimi, Marta Alene Owono, Escolástica Raquel Mansogo Mayé, Martín Eká Ondó Mangue, Genaro Nsué Nguema Okomo, Beltrán Ekuá Ntutumu Pasialo, Dolores Mbang Ondó Mandumbi, María-Silvia A. López Mikue, Fortunata Lobede Mochomuemue, Mariano Obiang Obono, Juan Carlos Momo Besahá, José Raso Bijeri, Gabriel Mbá Abegue, Yolanda Rimoy Veri, Ines Toichoa Bela, Federico Comsil Chochi, José Enrique Lima Sánchez, Vanessa Pencelli, Griselda Gayozo, José Antonio Esono Mbá Nlang, Tobias Schindler, Eric R. James, Yonas Abebe, Laurence Lemiale, Thomas C. Stabler, Tooba Murshedkar, Mei-Chun Chen, Christopher Schwabe, Josea Ratsirarson, Matilde Riloha Rivas, Mitoha Ondo’o Ayekaba, Diosdado Vicente Nsué Milang, Carlos Cortés Falla, Wonder P. Phiri, Guillermo A. García, Carl D. Maas, Bonifacio Manguire Nlavo, Marcel Tanner, Peter F. Billingsley, B. Kim Lee Sim, Claudia Daubenberger, Stephen L. Hoffman, Salim Abdulla, Thomas L. Richie

Publikováno v: The American journal of tropical medicine and hygiene.

Plasmodium falciparum sporozoite (PfSPZ) Vaccine is composed of radiation-attenuated, aseptic, purified cryopreserved PfSPZ. Multiple clinical trials empirically assessing two to six doses have shown multi-dose priming (two to four doses the first we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::084dea569c63a6d438e84d6df3f96b9a
https://pubmed.ncbi.nlm.nih.gov/35130487