In Vitro Identification of Phosphorylation Sites on TcPolβ by Protein Kinases TcCK1, TcCK2, TcAUK1, and TcPKC1 and Effect of Phorbol Ester on Activation by TcPKC of TcPolβ in Trypanosoma cruzi Epimastigotes

Autor: Edio Maldonado, Paz Canobra, Matías Oyarce, Fabiola Urbina, Vicente J. Miralles, Julio C. Tapia, Christian Castillo, Aldo Solari

Publikováno v: Microorganisms, Vol 12, Iss 5, p 907 (2024)

Chagas disease is caused by the single-flagellated protozoan Trypanosoma cruzi, which affects several million people worldwide. Understanding the signal transduction pathways involved in this parasite’s growth, adaptation, and differentiation is cr

Externí odkaz: https://doaj.org/article/1505753e82db4edd9bed7ad3297d0f5e

Dual and Opposite Roles of Reactive Oxygen Species (ROS) in Chagas Disease: Beneficial on the Pathogen and Harmful on the Host

Autor: Diego Rojas, Vicente J. Miralles, Edio Maldonado, Sebastián Morales, Aldo Solari

Publikováno v: Oxidative Medicine and Cellular Longevity, Vol 2020 (2020)
Oxidative Medicine and Cellular Longevity

Chagas disease is a neglected tropical disease, which affects an estimate of 6-7 million people worldwide. Chagas disease is caused by Trypanosoma cruzi, which is a eukaryotic flagellate unicellular organism. At the primary infection sites, these par

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8e89727185acad4e9f9c2290a513666
https://doaj.org/article/de7c7087f2ec4d93a884427ecce9ccfc

Inhibition of liver trans-sulphuration pathway by propargylglycine mimics gene expression changes found in the mammary gland of weaned lactating rats: role of glutathione

Autor: Federico V. Pallardó, Concha García, Luis Enrique Nores Torres, Teresa Barber, Vicente J. Miralles, A. Diana Rus, Juan R. Viña, Rosa Zaragozá

Publikováno v: Zaragozá, R.; García, C.; Rus, A.D.; Pallardó, F.V.; Barber, T.; Torres, L.; Miralles, J.V.; Viña J.R. (2003). Inhibition of liver trans-sulphuration pathway by propargylglycine mimics gene expression changes found in the mammary gland of weaned lactating rats: role of glutathione. En Biochemical Journal, 373, 825–834
RODERIC. Repositorio Institucional de la Universitat de Valéncia
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In the lactatingmammary gland, weaning produces mitochondrial cytochrome c release and nuclear DNA fragmentation, as determined by gel electrophoresis. This is followed by a significant decrease in lactation. Weaning for 2 h produces an early inducti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a83efdd5c89f2b4f64fb046716540fad
https://doi.org/10.1042/bj20030387

Casein kinase 2 inhibits HomolD-directed transcription by Rrn7 in Schizosaccharomyces pombe

Autor: Fabiola Urbina, Diego Rojas, Matías Montes, Edio Maldonado, Sandra Moreira-Ramos, Vicente J. Miralles

Publikováno v: The FEBS journal. 282(3)

In Schizosaccharomyces pombe, ribosomal protein gene (RPG) promoters contain a TATA analogue element called the HomolD box. The HomolD-binding protein Rrn7 forms a complex with the RNA polymerase II machinery. Despite the importance of ribosome bioge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0221fe2cf169ef59efcf2adf0f3a06bf
https://pubmed.ncbi.nlm.nih.gov/25410910

Elevated Expression of Liver γ-Cystathionase Is Required for the Maintenance of Lactation in Rats

Autor: Ana Triguero, Itziar Martı́nez-López, Vicente J. Miralles, Concha García, Juan R. Viña, Luis Enrique Nores Torres, Teresa Barber

Publikováno v: The Journal of Nutrition. 129:928-933

Liver gamma-cystathionase activity increases in rats during lactation; its inhibition due to propargylglycine is followed by a significant decrease in lactation. This is reversible by N-acetylcysteine administration. To study the role of liver gamma-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8817841e20fee7b38a15013f757e3d6
https://doi.org/10.1093/jn/129.5.928