Výsledky vyhledávání - "Vicente J, Arán"

5-Nitroindazole-based compounds: further studies for activity optimization as anti-Trypanosoma cruzi agents

Autor: Cristina Fonseca-Berzal, Alexandra Ibáñez-Escribano, Sonia de Castro, José A. Escario, Alicia Gómez-Barrio, Vicente J. Arán

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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In this study, a new series of eleven 5-nitroindazole derivatives (10−20) and a related 6-nitroquinazoline (21) was synthesized and tested in vitro against different forms of the kinetoplastid parasite Trypanosoma cruzi, etiological agent of Chagas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::650b37a24444c49249e9fce2a19ac0b8
http://hdl.handle.net/10261/279866

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5-Nitroindazole derivatives as potential therapeutic alternatives against Acanthamoeba castellanii

Autor: Rubén Martín-Escolano, Gregorio Pérez-Cordón, Vicente J. Arán, Clotilde Marín, Manuel Sánchez-Moreno, María José Rosales

Publikováno v: Digibug. Repositorio Institucional de la Universidad de Granada
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Digital.CSIC. Repositorio Institucional del CSIC

This work was supported by the Spanish MINECO, FEDER funds of the E.U. [CTQ2013-14892 and 2010-CSD2010-00065] ; the Unidad de Excelencia MDM [2015-0038] ; and the Generalitat Valenciana (PROMETEO II 2015-002) . R.M.-E. is grateful for the fellowship

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11687b922495f7c3ae9b4e508a9656c1

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Akademický článek

Validation of a modified fluorimetric assay for the screening of trichomonacidal drugs

Autor: Alexandra Ibáñez Escribano, Alfredo Meneses Marcel, Yanetsy Machado Tugores, Juan José Nogal Ruiz, Vicente J Arán Redó, José Antonio Escario García-Trevijano, Alicia Gómez Barrio

Publikováno v: Memorias do Instituto Oswaldo Cruz, Vol 107, Iss 5, Pp 637-643 (2012)

A fluorimetric microassay that uses a redox dye to determine the viability of the flagellate Trichomonas vaginalis has been optimised to provide a more sensitive method to evaluate potential trichomonacidal compounds. Resazurin has been used in recen

Externí odkaz: https://doaj.org/article/3d54a80d7ae7461d8654683bf4d01c96

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Akademický článek

Activity of 2-benzyl-1-(2-hydroxyethyl)-5-nitroindazolin-3-one on Trypanosoma cruzi Bloodstream Trypomastigotes (Y strain): In Vitro and In Vivo Studies

Autor: Cristina Fonseca-Berzal, Cristiane França da Silva, Marcos Meuser Batista, Francisca Hildemagna Guedes-da-Silva, Mariane Vasconcelos, Kelly C. Demarque, José A. Escario, Vicente J. Arán, Maria de Nazaré C. Soeiro, Alicia Gómez-Barrio

Publikováno v: Proceedings, Vol 1, Iss 6, p 655 (2017)

Benznidazole and nifurtimox, the currently available drugs for the specific treatment of Chagas disease, show limited effectiveness and high toxicity that prompt the identification of therapeutic alternatives. [...]

Externí odkaz: https://doaj.org/article/c81a0dfbbdf74a4084bf5ddef2f4bddb

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Promising hit compounds against resistant trichomoniasis: Synthesis and antiparasitic activity of 3-(ω-aminoalkoxy)-1-benzyl-5-nitroindazoles

Autor: Alexandra Ibáñez-Escribano, Nerea Vela, Felipe Reviriego, Cristina Fonseca-Berzal, Vicente J. Arán, Juan José Nogal-Ruiz, Alicia Gómez-Barrio, José Antonio Escario

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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E-Prints Complutense. Archivo Institucional de la UCM

A series of 11 3-(ω-aminoalkoxy)-1-benzyl-5-nitroindazoles (2–12) has been prepared starting from 1-benzyl-5-nitroindazol-3-ol 13, and evaluated against sensitive and resistant isolates of the sexually transmitted protozoan Trichomonas vaginalis.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a3001b7853b50b016b3da7f2e64b24d
https://eprints.ucm.es/id/eprint/70434/

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Activity profile of two 5-nitroindazole derivatives over the moderately drug-resistant

Autor: Cristina, Fonseca-Berzal, Cristiane França, da Silva, Denise da Gama Jaen, Batista, Gabriel Melo, de Oliveira, José, Cumella, Marcos Meuser, Batista, Raiza Brandão, Peres, Aline, Silva da Gama Nefertiti, José A, Escario, Alicia, Gómez-Barrio, Vicente J, Arán, Maria de Nazaré Correia, Soeiro

Publikováno v: Parasitology

In previous studies, we have identified several families of 5-nitroindazole derivatives as promising antichagasic prototypes. Among them, 1-(2-aminoethyl)-2-benzyl-5-nitro-1,2-dihydro-3H-indazol-3-one, (hydrochloride) and 1-(2-acetoxyethyl)-2-benzyl-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::befa5e3a346fc682c74fc468fe7e61fe
https://pubmed.ncbi.nlm.nih.gov/32530391

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Experimental models in Chagas disease: a review of the methodologies applied for screening compounds against Trypanosoma cruzi

Autor: Vicente J. Arán, Cristina Fonseca-Berzal, Alicia Gómez-Barrio, José Antonio Escario

Publikováno v: Parasitology Research. 117:3367-3380

One of the main problems of Chagas disease (CD), the parasitic infection caused by Trypanosoma cruzi, is the lack of a completely satisfactory treatment, which is currently based on two old nitroheterocyclic drugs (i.e., nifurtimox and benznidazole)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::158ab5a7794c5773de30830a3cc41ba8
https://doi.org/10.1007/s00436-018-6084-3

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Identification, occurrence and activity of quinazoline alkaloids in Peganum harmala

Autor: Vicente J. Arán, Tomás Herraiz, Antonio Salgado, Hugo Guillén

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Peganum harmala L. is a medicinal plant from the Mediterranean region and Asia currently used for recreative psychoactive purposes (Ayahuasca analogue), and increasingly involved in toxic cases. Its psychopharmacological and toxicological properties

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ef4351fd7a82f0bdc01c453aff9da9a
https://doi.org/10.1016/j.fct.2017.03.010

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