Výsledky vyhledávání - "Vicente Herrero Aguayo"

Akademický článek

Dysregulation of the miRNome unveils a crosstalk between obesity and prostate cancer: miR-107 asa personalized diagnostic and therapeutic tool

Autor: Vicente Herrero-Aguayo, Prudencio Sáez-Martínez, Juan M. Jiménez-Vacas, M. Trinidad Moreno-Montilla, Antonio J. Montero-Hidalgo, Jesús M. Pérez-Gómez, Juan L. López-Canovas, Francisco Porcel-Pastrana, Julia Carrasco-Valiente, Francisco J. Anglada, Enrique Gómez-Gómez, Elena M. Yubero-Serrano, Alejandro Ibañez-Costa, Aura D. Herrera-Martínez, André Sarmento-Cabral, Manuel D. Gahete, Raúl M. Luque

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 27, Iss , Pp 1164-1178 (2022)

Prostate-specific antigen (PSA) is the gold-standard marker to screen prostate cancer (PCa) nowadays. Unfortunately, its lack of specificity and sensitivity makes the identification of novel tools to diagnose PCa an urgent medical need. In this conte

Externí odkaz: https://doaj.org/article/d4c45f418c84437da6d022bf2fddd485

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Akademický článek

Dysregulated splicing factor SF3B1 unveils a dual therapeutic vulnerability to target pancreatic cancer cells and cancer stem cells with an anti-splicing drug

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-21 (2021)

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer, requiring novel treatments to target both cancer cells and cancer stem cells (CSCs). Altered splicing is emerging as both a novel cancer hallmark and an attractive

Externí odkaz: https://doaj.org/article/2e57a0d7fd7f42d6a9f88e1c0cae6aca

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Akademický článek

Dysregulation of the splicing machinery is directly associated to aggressiveness of prostate cancer

Autor: Juan M. Jiménez-Vacas, Vicente Herrero-Aguayo, Antonio J. Montero-Hidalgo, Enrique Gómez-Gómez, Antonio C. Fuentes-Fayos, Antonio J. León-González, Prudencio Sáez-Martínez, Emilia Alors-Pérez, Sergio Pedraza-Arévalo, Teresa González-Serrano, Oscar Reyes, Ana Martínez-López, Rafael Sánchez-Sánchez, Sebastián Ventura, Elena M. Yubero-Serrano, María J. Requena-Tapia, Justo P. Castaño, Manuel D. Gahete, Raúl M. Luque

Publikováno v: EBioMedicine, Vol 51, Iss , Pp - (2020)

Background: Dysregulation of splicing variants (SVs) expression has recently emerged as a novel cancer hallmark. Although the generation of aberrant SVs (e.g. AR-v7/sst5TMD4/etc.) is associated to prostate-cancer (PCa) aggressiveness and/or castratio

Externí odkaz: https://doaj.org/article/2ef43292c5e645488d2beac6b2a5afe9

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Akademický článek

Comparative Cytotoxic Activity of Hydroxytyrosol and Its Semisynthetic Lipophilic Derivatives in Prostate Cancer Cells

Autor: Antonio J. León-González, Prudencio Sáez-Martínez, Juan M. Jiménez-Vacas, Vicente Herrero-Aguayo, Antonio J. Montero-Hidalgo, Enrique Gómez-Gómez, Andrés Madrona, Justo P. Castaño, José L. Espartero, Manuel D. Gahete, Raúl M. Luque

Publikováno v: Antioxidants, Vol 10, Iss 9, p 1348 (2021)

A high adherence to a Mediterranean diet has been related to numerous beneficial effects in human health, including a lower incidence and mortality of prostate cancer (PCa). Olive oil is an important source of phenolic bioactive compounds, mainly hyd

Externí odkaz: https://doaj.org/article/c09a7cc0dc304780804deebca25018fa

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Inflammasomes: Cause or consequence of obesity-associated comorbidities in humans

Autor: Aura D. Herrera‐Martínez, Vicente Herrero‐Aguayo, Jesús M. Pérez‐Gómez, Manuel D. Gahete, Raúl M. Luque

Publikováno v: Obesity (Silver Spring, Md.)REFERENCES. 30(12)

Inflammasomes are multiprotein intracellular complexes composed of innate immune system receptors and sensors; they activate the inflammatory cascade in response to infectious microbes and/or molecules derived from host proteins. Because of cytokine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd738975f5738768f048c438ec37cf61
https://pubmed.ncbi.nlm.nih.gov/36415999

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HIF-2α Preserves Mitochondrial Activity and Glucose Sensing in Compensating β-Cells in Obesity

Autor: Jae-Su Moon, Matthew Riopel, Jong Bae Seo, Vicente Herrero-Aguayo, Roi Isaac, Yun Sok Lee

Publikováno v: Diabetes, vol 71, iss 7
Diabetes

In obesity, increased mitochondrial metabolism with the accumulation of oxidative stress leads to mitochondrial damage and β-cell dysfunction. In particular, β-cells express antioxidant enzymes at relatively low levels and are highly vulnerable to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db8a624d97f032b89613550d5c9c12e1
https://escholarship.org/uc/item/0kz0c5dw

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HIF-2α Preserves Mitochondrial Activity And Glucose Sensing in Compensating Beta Cells in Obesity

Autor: Yun Sok Lee, Roi Isaac, Vicente Herrero-Aguayo, Jong Bae Seo, Matthew Riopel, Jae-Su Moon

In obesity, increased mitochondrial metabolism with the accumulation of oxidative stress leads to mitochondrial damage and beta cell dysfunction. In particular, beta cells express anti-oxidant enzymes at relatively low levels and are highly vulnerabl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::485c525235e6e10d31bf5cdb1184ee43
https://doi.org/10.2337/figshare.19607331

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