Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Vicente Gómez-Parra"'
Autor:
Félix Sánchez-Alonso, Juan-Julio Bonet, Antonio Alivert, Francesc Canals, Vicente Gómez-Parra
Publikováno v:
Archiv der Pharmazie. 324:559-561
The synthesis and preliminary assays as hypocholesterolemic agents of five N-diphenylmethylpiperazines are described. The evaluations were carried out in hypercholesterolemic mice and two of these compounds were more effective than bezafibrate in the
Publikováno v:
ChemInform. 24
For development of new cardiotonic agents a series of 5-aryl-3,4-dihydropyridin-2(1H)-ones, related to amrinone have been prepared from methylquinolines, 2-arylacetic acid or 3-arylethanones by direct aminomethylenation and subsequent condensation-cy
Publikováno v:
Scopus-Elsevier
For development of new cardiotonic agents a series of 5-aryl-3,4-dihydropyridin-2(1H)-ones, related to amrinone have been prepared from methylquinolines, 2-arylacetic acid or 3-arylethanones by direct aminomethylenation and subsequent condensation-cy
Publikováno v:
Monatshefte für Chemie - Chemical Monthly. 116:639-644
A new procedure for preparing 1-alkyl-1,3-dihydro-2H-benzimidazol-2-ones fromo-nitroanilines by successive ethoxycarbonylation, catalytic hydrogenation and thermal cyclization under neutral conditions is described.
Publikováno v:
Liebigs Annalen der Chemie. 1985:1465-1473
The synthesis of several 4- and 5-alkoxy-substituted pyridazin-3(2H)-ones with hypotensive and β-blocking activities by phase-transfer catalysis (PTC) starting from halopyridazin-3(2H)-ones is described. The nucleophilic displacement reaction procee
Publikováno v:
Scopus-Elsevier
A series of quinazolines, with cardiovascular activity, having 2,3-dihydroxypropoxy or 2-hydroxy-3-t- butylaminopropoxy groups substituted at the 4-position and chlorine or 2-aroylpiperazinyl groups at the 2-position have been synthesized. The introd
Publikováno v:
Synthesis. 1985:282-285
Publikováno v:
Liebigs Annalen der Chemie. 1989:539-544
The synthesis of a series of new 4-[(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)alkoxycarbonyl]-1-(diphenylmethyl)piperazines 2 by phase-transfer catalysed monoalkoxycarbonylation of α,ω-dichloroalkanes is described. Compounds 2 are related to oxatomid
Publikováno v:
Archiv der Pharmazie. 319:60-64
The synthesis of the biologically active 4,5-disubstituted pyridazin-3(2H)-ones 6 and 7 starting from the 4,5-Dihalopyridazinones 2 is described.
Publikováno v:
Scopus-Elsevier
A 24 factorial design has been applied to the study of the competitive alkylation versus alkoxycarbonylation of secondary alkyl amines under phase-transfer conditions. The relative influence of the experimental variables and their interactions in the