Toxicological Profiling and Long-Term Effects of Bare, PEGylated- and Galacto-Oligosaccharide-Functionalized Mesoporous Silica Nanoparticles

Autor: Irene Barguilla, Vicente Candela-Noguera, Patrick Oliver, Balasubramanyam Annangi, Paula Díez, Elena Aznar, Ramón Martínez-Máñez, Ricard Marcos, Alba Hernández, María Dolores Marcos

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 22, p 16158 (2023)

Mesoporous silica nanoparticles (MSNs) are amongst the most used nanoparticles in biomedicine. However, the potentially toxic effects of MSNs have not yet been fully evaluated, being a controversial matter in research. In this study, bare MSNs, PEGyl

Externí odkaz: https://doaj.org/article/e032d0ec74784449b12e3938281283d0

Antibacterial Activity of Linezolid against Gram-Negative Bacteria: Utilization of ε-Poly-l-Lysine Capped Silica Xerogel as an Activating Carrier

Autor: Gulcihan Guzel Kaya, Serena Medaglia, Vicente Candela-Noguera, María Ángeles Tormo-Mas, María Dolores Marcos, Elena Aznar, Huseyin Deveci, Ramón Martínez-Máñez

Publikováno v: Pharmaceutics, Vol 12, Iss 11, p 1126 (2020)

In recent times, many approaches have been developed against drug resistant Gram-negative bacteria. However, low-cost high effective materials which could broaden the spectrum of antibiotics are still needed. In this study, enhancement of linezolid s

Externí odkaz: https://doaj.org/article/92841b9bedf3464a815c3619cd364b8d

Biocompatibility and internalization assessment of bare and functionalised mesoporous silica nanoparticles

Autor: Pilar Eroles, M. Dolores Marcos, Guadalupe Herrera, Iris Garrido-Cano, Ramón Martínez-Máñez, Juan Miguel Cejalvo, Ana Lluch, Félix Sancenón, Vicente Candela-Noguera

Publikováno v: MICROPOROUS AND MESOPOROUS MATERIALS
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
instname
RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA

[EN] We report herein an evaluation of the effect of several mesoporous silica nanoparticles (MSNs) on the cellular uptake and in vitro cytotoxicity in human cells. Bare MSNs and MSNs functionalized with polyethylene glycol or hyaluronic acid are emp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1450492c618d7f05640576877a220906
https://fundanet.cipf.es/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3631

Design of oligonucleotide-capped mesoporous silica nanoparticles for the detection of miRNA-145 by duplex and triplex formation

Autor: Elena Aznar, Àngela Ribes, Ramón Martínez-Máñez, Félix Sancenón, Ramon Eritja, Anna Aviñó, Sara Santiago-Felipe, Vicente Candela-Noguera

Publikováno v: SENSORS AND ACTUATORS B-CHEMICAL
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
instname
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
Digital.CSIC. Repositorio Institucional del CSIC
RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia

The development of new strategies to detect microRNAs (miRNAS) has become an important challenge in the biomedical field. We report herein the use of oligonucleotide-gated silica nanoparticles for the detection of miRNA-145. In the proposed design, m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a72202f69ff4e81d048d54a04ec2b290
http://hdl.handle.net/10261/170312