Polypeptide-corticosteroid conjugates as a topical treatment approach to psoriasis

Autor: Daniel Morelló-Bolumar, Marwa Ahmed Sallam, Sarah Hedtrich, Irene Dolz-Pérez, María J. Vicent, Vicent J. Nebot, Doaa A Abdelmonsif, Patrick Graff, M. Dolores Pérez del Caz, Esther Masiá

Publikováno v: Journal of Controlled Release. 318:210-222

Topical treatment of mild-to-moderate psoriasis with corticosteroids suffers from challenges that include reduced drug bioavailability at the desired site of action. The retention of therapeutics within the epidermis can safely treat skin inflammatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c746f20060cd20b23beb8d98bb514a9c
https://doi.org/10.1016/j.jconrel.2019.12.016

Polymer Conjugation of Docosahexaenoic Acid Potentiates Cardioprotective Therapy in Preclinical Models of Myocardial Ischemia/Reperfusion Injury

Autor: Begoña Igual, Imelda Ontoria-Oviedo, Pilar Sepúlveda, Hernán González-King, Jose Luis Diez, Caitlin G. Decker, Delia Castellano, María J. Vicent, Raquel Álvarez, Nahuel A. García, Irene Dolz-Pérez, Sandra Tejedor, Vicent J. Nebot, Hernándiz A

Publikováno v: Advanced Healthcare Materials
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)

While coronary angioplasty represents an effective treatment option following acute myocardial infarction, the reperfusion of the occluded coronary artery can prompt ischemia-reperfusion (I/R) injury that significantly impacts patient outcomes. As om

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d2c2f419d1234f4464aee156651664e
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=14017

Anticancer Activity Driven by Drug Linker Modification in a Polyglutamic Acid‐Based Combination‐Drug Conjugate

Autor: Alison Paul, Vicent J. Nebot, David Charbonnier, Coralie Deladriere, María J. Vicent, Juan J. Arroyo-Crespo, Esther Masiá, Craig James, Ana Armiñán

Publikováno v: ADVANCED FUNCTIONAL MATERIALS
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
'Advanced Functional Materials ', vol: 28, pages: 1800931-1-1800931-13 (2018)
Advanced Functional Materials
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
instname

Combination nanotherapies for the treatment of breast cancer permits synergistic drug targeting of multiple pathways. However, poor carrier degradability, poor synergism of the combined drugs, low drug release regulation, and a lack of control on fin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7584261baca90f224b02c93e6d01b05a
https://zenodo.org/record/1227320

Relevant Physicochemical Descriptors of 'Soft Nanomedicines' to Bypass Biological Barriers

Autor: Vicent J. Nebot, María J. Vicent, Amaya Niño-Pariente

Publikováno v: Current Pharmaceutical Design
CURRENT PHARMACEUTICAL DESIGN
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
instname
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)

Herein, we present an overview on the current status of the characterization techniques and methodologies used to study the physicochemical descriptors that influence the final clinical performance of a given nanomedicine. The described techniques we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f405fb04edcb4adf5b107b436bac7365

Water soluble azido polyisocyanopeptides as functional β-sheet mimics

Autor: René de Gelder, Vicent J. Nebot-Carda, Erik Schwartz, Alan E. Rowan, Jeroen J. L. M. Cornelissen, Mónica Espelt, Roeland J. M. Nolte, Matthieu Koepf, Heather J. Kitto

Publikováno v: Journal of Polymer Science Part A: Polymer Chemistry. 47:4150-4164

The design and synthesis of functional biomimetic water soluble polymers with a defined secondary structure has been developed using β-sheet polyisocyanopeptide scaffolds. Water soluble isocyanopolymers were prepared by random copolymerisation of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::96e046d19b16ce513c12431593913834
https://doi.org/10.1002/pola.23477