Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Vicent Casado"'
Autor:
Michael Michaelides, Marjorie Levinstein, Paulo De Oliveira, Nil Casajuana-Martin, Cesar Quiroz, Reece Budinich, Rana Rais, William Rea, Emilya Ventriglia, Natàlia Llopart, Verònica Casadó-Anguera, Estefanía Moreno, Donna Walther, Grant Glatfelter, David Weinshenker, Carlos Zarate, Vicent Casado, Michael Baumann, Leonardo Pardo, Sergi Ferre
(R,S)-methadone ((R,S)-MTD) is a racemic µ-opioid receptor (MOR) agonist comprised of (R)-MTD and (S)-MTD enantiomers used for the treatment of opioid use disorder (OUD) and pain. (R)-MTD is used as an OUD treatment, has high MOR potency, and is bel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7f9edba861e03efbb88c21c794161e2
https://doi.org/10.21203/rs.3.rs-2644719/v1
https://doi.org/10.21203/rs.3.rs-2644719/v1
Autor:
Irene Maroto, Carlos Costas-Insua, Coralie Berthoux, Estefania Moreno, Andrea Ruiz-Calvo, Carlos Montero-Fernández, Andrea Macías-Camero, Ricardo Martín, Nuria García-Font, José Sánchez-Prieto, Giovanni Marsicano, Luigi Bellocchio, Enric Canela, Vicent Casado, Ismael Galve-Roperh, David Fernandez de Sevilla, Ignacio Rodríguez-Crespo, Pablo Castillo, Manuel Guzmán
The type-1 cannabinoid receptor (CB1R) is widely expressed in both excitatory and inhibitory nerve terminals, and its activation, by suppressing neurotransmitter release, modulates neural circuits and brain function. While the interaction of CB1R wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbe7ee7b82e20f34c072bc9d419c1894
https://doi.org/10.21203/rs.3.rs-2128033/v1
https://doi.org/10.21203/rs.3.rs-2128033/v1
The CB1 receptor interacts with cereblon and drives cereblon deficiency-associated memory shortfalls
Autor:
Carlos Costas-Insua, Alba Hermoso-López, Estefanía Moreno, Carlos Montero-Fernández, Alicia Álvaro-Blázquez, Irene B Maroto, Andrea Sánchez-Ruiz, Rebeca Diez-Alarcia, Cristina Blázquez, Paula Morales, Enric I Canela, Vicent Casadó, Leyre Urigüen, Gertrudis Perea, Luigi Bellocchio, Ignacio Rodríguez-Crespo, Manuel Guzmán
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 4, Pp 755-783 (2024)
Abstract Cereblon/CRBN is a substrate-recognition component of the Cullin4A-DDB1-Roc1 E3 ubiquitin ligase complex. Destabilizing mutations in the human CRBN gene cause a form of autosomal recessive non-syndromic intellectual disability (ARNSID) that
Externí odkaz:
https://doaj.org/article/5c7b69f9446144719e20ce1f4a631547
Autor:
Irene B. Maroto, Carlos Costas-Insua, Coralie Berthoux, Estefanía Moreno, Andrea Ruiz-Calvo, Carlos Montero-Fernández, Andrea Macías-Camero, Ricardo Martín, Nuria García-Font, José Sánchez-Prieto, Giovanni Marsicano, Luigi Bellocchio, Enric I. Canela, Vicent Casadó, Ismael Galve-Roperh, Ángel Núñez, David Fernández de Sevilla, Ignacio Rodríguez-Crespo, Pablo E. Castillo, Manuel Guzmán
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The type-1 cannabinoid receptor (CB1R) is widely expressed in excitatory and inhibitory nerve terminals, and by suppressing neurotransmitter release, its activation modulates neural circuits and brain function. While the interaction of CB1R
Externí odkaz:
https://doaj.org/article/de2f897065d34da0933b217db4f53983
Autor:
Alba Hermoso-López, Carlos Costas-Insua, Carlos Montero-Fernández, Estefanía Moreno, Alicia Álvaro-Blázquez, David Martín-Gutiérrez, Irene B. Maroto-Martínez, Rebeca Diez-Alarcia, Leyre Urigüen, Vicent Casadó, Ignacio Rodríguez-Crespo, Manuel Guzmán
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S848- (2023)
Externí odkaz:
https://doaj.org/article/b668f7103ab240249d28d67435c8975d
Autor:
Sergi Ferré, Annabelle M. Belcher, Jordi Bonaventura, César Quiroz, Marta Sánchez-Soto, Verònica Casadó-Anguera, Ning-Sheng Cai, Estefanía Moreno, Comfort A. Boateng, Thomas M. Keck, Benjamín Florán, Christopher J. Earley, Francisco Ciruela, Vicent Casadó, Marcelo Rubinstein, Nora D. Volkow
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
The functional and pharmacological significance of the dopamine D4 receptor (D4R) has remained the least well understood of all the dopamine receptor subtypes. Even more enigmatic has been the role of the very prevalent human DRD4 gene polymorphisms
Externí odkaz:
https://doaj.org/article/296e48e160894ee886f69c1f180469c2
Autor:
Attila Köfalvi, Estefanía Moreno, Arnau Cordomí, Ning-Sheng Cai, Victor Fernández-Dueñas, Samira G. Ferreira, Ramón Guixà-González, Marta Sánchez-Soto, Hideaki Yano, Verònica Casadó-Anguera, Rodrigo A. Cunha, Ana Maria Sebastião, Francisco Ciruela, Leonardo Pardo, Vicent Casadó, Sergi Ferré
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-21 (2020)
Abstract Background It has been hypothesized that heteromers of adenosine A2A receptors (A2AR) and cannabinoid CB1 receptors (CB1R) localized in glutamatergic nerve terminals mediate the integration of adenosine and endocannabinoid signaling involved
Externí odkaz:
https://doaj.org/article/7b04e035274446de8e3bed6703c6c493
Autor:
Carlo Matera, Pablo Calvé, Verònica Casadó-Anguera, Rosalba Sortino, Alexandre M. J. Gomila, Estefanía Moreno, Thomas Gener, Cristina Delgado-Sallent, Pau Nebot, Davide Costazza, Sara Conde-Berriozabal, Mercè Masana, Jordi Hernando, Vicent Casadó, M. Victoria Puig, Pau Gorostiza
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 10114 (2022)
Understanding the dopaminergic system is a priority in neurobiology and neuropharmacology. Dopamine receptors are involved in the modulation of fundamental physiological functions, and dysregulation of dopaminergic transmission is associated with maj
Externí odkaz:
https://doaj.org/article/e2bdf135b54a428ab7ab2892ef4d150b
Autor:
David Moreno-Delgado, Mar Puigdellívol, Estefanía Moreno, Mar Rodríguez-Ruiz, Joaquín Botta, Paola Gasperini, Anna Chiarlone, Lesley A Howell, Marco Scarselli, Vicent Casadó, Antoni Cortés, Sergi Ferré, Manuel Guzmán, Carmen Lluís, Jordi Alberch, Enric I Canela, Silvia Ginés, Peter J McCormick
Publikováno v:
eLife, Vol 9 (2020)
Early Huntington’s disease (HD) include over-activation of dopamine D1 receptors (D1R), producing an imbalance in dopaminergic neurotransmission and cell death. To reduce D1R over-activation, we present a strategy based on targeting complexes of D1
Externí odkaz:
https://doaj.org/article/e29f5e9398d54a2882b616c452b949ae
Autor:
Gemma Navarro, Arnau Cordomí, Verónica Casadó-Anguera, Estefanía Moreno, Ning-Sheng Cai, Antoni Cortés, Enric I. Canela, Carmen W. Dessauer, Vicent Casadó, Leonardo Pardo, Carme Lluís, Sergi Ferré
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
It is unclear whether GPCRs, G proteins and adenylyl cyclase (AC) associate through random collisions or defined pre-coupling mechanisms. Using a peptide-based approach, the authors show that heteromers of adenosine A2A and dopamine D2 receptors form
Externí odkaz:
https://doaj.org/article/ddb2e76a96254f8299931ae5586deefc