Výsledky vyhledávání - "Vicenistatin"

Complex structure of the acyltransferase VinK and the carrier protein VinL with a pantetheine cross-linking probe

Autor: Risako Ouchi, Akimasa Miyanaga, Fumitaka Kudo, Tadashi Eguchi

Publikováno v: Acta Crystallogr F Struct Biol Commun

Acyltransferases are responsible for the selection and loading of acyl units onto carrier proteins in polyketide and fatty-acid biosynthesis. Despite the importance of protein–protein interactions between the acyltransferase and the carrier protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc7716a6aa0acfdca095215c7bcdcdc2
https://doi.org/10.1107/s2053230x21008761

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Mechanisms of β-amino acid incorporation in polyketide macrolactam biosynthesis

Autor: Tadashi Eguchi, Akimasa Miyanaga, Fumitaka Kudo

Publikováno v: Current Opinion in Chemical Biology. 35:58-64

Macrolactam antibiotics are an important class of macrocyclic polyketides. In recent years, the number of identified β-amino acid-containing macrolactams and their biosynthetic gene clusters have greatly expanded. Functional analyses of vicenistatin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b33f26ea1d376f2820061e7063517d7
https://doi.org/10.1016/j.cbpa.2016.08.030

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Vicenistatin induces early endosome-derived vacuole formation in mammalian cells

Autor: Hiroyuki Osada, Fumitaka Kudo, Hiroki Iwasaki, Yoshiharu Iwabuchi, Yoko Nagumo, Takeo Usui, Sosaku Ichikawa, Kousuke Mano, Sayaka Kazami, Yuko Nishiyama, Naoki Kanoh, Tadashi Eguchi, Tomohiro Ohmichi

Publikováno v: ResearcherID

Homotypic fusion of early endosomes is important for efficient protein trafficking and sorting. The key controller of this process is Rab5 which regulates several effectors and PtdInsPs levels, but whose mechanisms are largely unknown. Here, we repor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::329a836bf673cf5e6edf5c28130f1768
https://doi.org/10.1080/09168451.2015.1132152

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Cooperative Involvement of Glycosyltransferases in the Transfer of Amino Sugars during the Biosynthesis of the Macrolactam Sipanmycin by Streptomyces sp. Strain CS149

Autor: Mónica G. Malmierca, Ignacio Pérez-Victoria, Fernando Reyes, Carmen Méndez, Carlos Olano, José A. Salas, Jesús Martín

Macrolactams comprise a family of natural compounds with important bioactivities, such as antibiotic, antifungal, and antiproliferative activities. Sipanmycins A and B are two novel members of this family, with two sugar moieties attached to the agly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf716bc5934027439ad70562d48d9853
https://europepmc.org/articles/PMC6121974/

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Searching for Glycosylated Natural Products in Actinomycetes and Identification of Novel Macrolactams and Angucyclines

Autor: Mónica G. Malmierca, Lorena González-Montes, Ignacio Pérez-Victoria, Carlos Sialer, Alfredo F. Braña, Raúl García Salcedo, Jesús Martín, Fernando Reyes, Carmen Méndez, Carlos Olano, José A. Salas

Publikováno v: Frontiers in Microbiology
Frontiers in Microbiology, Vol 9 (2018)
Scopus
RUO. Repositorio Institucional de la Universidad de Oviedo
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Many bioactive natural products are glycosylated compounds in which the sugar components usually participate in interaction and molecular recognition of the cellular target. Therefore, the presence of sugar moieties is important, in some cases essent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7d0b54b4a529bc1c68f2f09fd1dac3c
https://pubmed.ncbi.nlm.nih.gov/29441046

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Isolation and Structure Elucidation of Vicenistatin M, and Importance of the Vicenisamine Aminosugar for Exerting Cytotoxicity of Vicenistatin

Autor: Yoshitaka Matsushima, Kazutoshi Shindo, Renuka Bhandari, Katsumi Kakinuma, Tadashi Eguchi, Masaki Fujita, Takuya Nakayama

Publikováno v: The Journal of Antibiotics. 54:211-219

A new analogue of vicenistatin was isolated from the producing strain Streptomyces sp. HC-34. A characteristic of the elucidated structure involved the existence of a neutral sugar mycarose instead of an aminosugar vicenisamine of vicenistatin. The a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9330063b687a05682f5e3bf035c42f9d
https://doi.org/10.7164/antibiotics.54.211

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Potent Oligomerization and Macrocyclization Activity of the Thioesterase Domain of Vicenistatin Polyketide Synthase

Autor: Moe Watanabe, Yusaku Asou, Tadashi Eguchi, Fumitaka Kudo, Takashi Kitayama

Publikováno v: Synlett. 23:1843-1846

The thioesterase domain of the polyketide synthase involved in the biosynthesis of the 20-membered macrolactam antibiotic vicenistatin (VinTE) was found to catalyze oligomerization and macrocyclization of ω-hydroxy fatty acid ethyl esters to afford

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c41e8512609ff94f76c861c9db218ff7
https://doi.org/10.1055/s-0031-1290385

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