Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Vic Ciaravino"'
Publikováno v:
Journal of Dermatological Science. 87:116-122
Background Crisaborole is a novel, topical nonsteroidal, anti-inflammatory, phosphodiesterase 4 (PDE4) inhibitor for the treatment of mild to moderate atopic dermatitis. Objective As part of a nonclinical safety testing program, these 2-year studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::184b2f6a415918ef784e8b4597fb3e3b
https://doi.org/10.1016/j.jdermsci.2017.03.020
https://doi.org/10.1016/j.jdermsci.2017.03.020
Autor:
Jacob J. Plattner, Yong-Kang Zhang, Francisco-Javier Gamo, Eric E. Easom, Laura M. Sanz, Philip J. Rosenthal, Yvonne Freund, Robert T. Jacobs, Brice Campo, Denghui Guo, Vic Ciaravino, Jianxin Cao, Pamela Berry, John C. L. Erve
Publikováno v:
Journal of Medicinal Chemistry. 60:5889-5908
Carboxamide pyrazinyloxy benzoxaboroles were investigated with the goal to identify a molecule with satisfactory antimalarial activity, physicochemical properties, pharmacokinetic profile, in vivo efficacy, and safety profile. This optimization effor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf7593ef9390da411669370e393e82e6
https://doi.org/10.1021/acs.jmedchem.7b00621
https://doi.org/10.1021/acs.jmedchem.7b00621
Publikováno v:
International Journal of Toxicology. 35:530-542
Tavaborole is a topical antifungal agent approved by the US Food and Drug Administration for the treatment of toenail onychomycosis. As part of the nonclinical development program, reproductive and developmental toxicity studies were conducted (rat o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ce445a3036bf4a8872a95d0495e14d7
https://doi.org/10.1177/1091581816639113
https://doi.org/10.1177/1091581816639113
Publikováno v:
Environmental and Molecular Mutagenesis. 54:338-346
Boron-containing compounds are being studied as potential therapeutic agents. As part of the safety assessment of these therapeutic agents, a battery of genetic toxicology studies was conducted. The battery included a bacterial reverse mutation (Ames
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59f528e0c14f2758ea53922e59b206cc
https://doi.org/10.1002/em.21779
https://doi.org/10.1002/em.21779
Publikováno v:
International journal of toxicology. 35(5)
Tavaborole is a topical antifungal agent approved by the US Food and Drug Administration for the treatment of toenail onychomycosis. The effects of tavaborole on gestation, parturition (delivery, labor), offspring development, and survival during the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7485fe6d9e6da271217fa4dc74dd02b
https://pubmed.ncbi.nlm.nih.gov/27138050
https://pubmed.ncbi.nlm.nih.gov/27138050
Autor:
Kurt, Jarnagin, Sanjay, Chanda, Dina, Coronado, Vic, Ciaravino, Lee T, Zane, Emma, Guttman-Yassky, Mark G, Lebwohl
Publikováno v:
Journal of drugs in dermatology : JDD. 15(4)
Crisaborole topical ointment, 2% (formerly known as AN2728) is a benzoxaborole, nonsteroidal, topical, anti-inflammatory phosphodiesterase 4 (PDE4) inhibitor investigational compound that recently completed phase 3 studies for the treatment of mild t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a064de8756fae3116fe85141887c89f6
https://pubmed.ncbi.nlm.nih.gov/27050693
https://pubmed.ncbi.nlm.nih.gov/27050693
Publikováno v:
Transfusion. 51:2208-2218
BACKGROUND: A system has been developed to inactivate a wide spectrum of blood-borne pathogens in red blood cells (RBCs) before transfusion. The system utilizes S-303 to target nucleic acids of pathogens and white blood cells. The safety of pathogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2c8a5c71b5033980f59ff75583e2ea2
https://doi.org/10.1111/j.1537-2995.2011.03132.x
https://doi.org/10.1111/j.1537-2995.2011.03132.x
Publikováno v:
Transfusion. 49:985-994
BACKGROUND: It is estimated that approximately 300,000 neonates undergo transfusions annually. The neonatal immune system is immature, making such patients more susceptible to the effects associated with transfusion-transmitted bacteria, viruses, pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2234174ca0bf1d5edcb39d4e386da94
https://doi.org/10.1111/j.1537-2995.2008.02076.x
https://doi.org/10.1111/j.1537-2995.2008.02076.x
Publikováno v:
Transfusion. 43:1481-1492
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df29ee8c3ba4c2c2b72004a2dc6c3b1a
https://doi.org/10.1046/j.1537-2995.2003.00544.x
https://doi.org/10.1046/j.1537-2995.2003.00544.x
Publikováno v:
International journal of toxicology. 33(5)
Tavaborole, a cyclized boronic acid, has been approved by the Food and Drug Administration for the topical treatment of toenail onychomycosis. This novel, low-molecular-weight pharmaceutical compound has broad-spectrum antifungal activity against der
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dff1be7e4e132042bdb8ced85ffcf4c
https://pubmed.ncbi.nlm.nih.gov/25201897
https://pubmed.ncbi.nlm.nih.gov/25201897