Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Vibha N. Lama"'
Autor:
Keizo Misumi, David S. Wheeler, Yoshiro Aoki, Michael P. Combs, Russell R. Braeuer, Ryuji Higashikubo, Wenjun Li, Daniel Kreisel, Ragini Vittal, Jeffrey Myers, Amir Lagstein, Natalie M. Walker, Carol F. Farver, Vibha N. Lama
Publikováno v:
JCI Insight, Vol 5, Iss 23 (2020)
Understanding the distinct pathogenic mechanisms that culminate in allograft fibrosis and chronic graft failure is key in improving outcomes after solid organ transplantation. Here, we describe an F1 → parent orthotopic lung transplant model of res
Externí odkaz:
https://doaj.org/article/23cc3c55a9cf486dad2c4230b7195d23
Autor:
Sundaresh Ram, Stijn E. Verleden, Alexander J. Bell, Benjamin A. Hoff, Wassim W. Labaki, Susan Murray, Bart M. Vanaudenaerde, Robin Vos, Geert M. Verleden, Ella A. Kazerooni, Stefanie Galbán, Charles R. Hatt, Meilan K. Han, Vibha N. Lama, Craig J. Galbán
Publikováno v:
Cells, Vol 11, Iss 4, p 699 (2022)
Chronic rejection of lung allografts has two major subtypes, bronchiolitis obliterans syndrome (BOS) and restrictive allograft syndrome (RAS), which present radiologically either as air trapping with small airways disease or with persistent pleuropar
Externí odkaz:
https://doaj.org/article/76c0d4e841aa4f1fae91f3f061539207
Autor:
Jennifer Speth, Loka R. Penke, Joseph Bazzill, Douglas A. Arenberg, James J. Moon, Venkateshwar G. Keshamouni, Vibha N. Lama, Marc Peters-Golden
Publikováno v:
Journal of Clinical and Translational Science, Vol 2, Pp 36-36 (2018)
OBJECTIVES/SPECIFIC AIMS: Insufficient endogenous expression of suppressor of cytokine signaling 3 (SOCS3) with subsequent over-activation of its target, the transcription factor STAT3, has been associated with tumorigenesis and cancer development in
Externí odkaz:
https://doaj.org/article/15405acec5eb411da761d139c5734010
Autor:
Yoshiro Aoki, Natalie M. Walker, Keizo Misumi, Takeshi Mimura, Ragini Vittal, Aidan P. McLinden, Linda Fitzgerald, Michael P. Combs, Dennis Lyu, John J. Osterholzer, David J. Pinsky, Vibha N. Lama
Publikováno v:
The Journal of Heart and Lung Transplantation. 42:317-326
Small airway inflammation and fibrosis or bronchiolitis obliterans (BO) is the predominant presentation of chronic lung allograft dysfunction (CLAD) post-lung transplantation. Carbon monoxide (CO) is a critical endogenous signaling transducer with kn
Autor:
Ragini Vittal, Amanda J. Fisher, Eric L. Thompson, Ellyse M. Cipolla, Hongmei Gu, Elizabeth A. Mickler, Ananya Varre, Manisha Agarwal, Kevin K. Kim, Michael R. Vasko, Bethany B. Moore, Vibha N. Lama
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 67:459-470
CD55 or decay accelerating factor (DAF), a ubiquitously expressed glycosylphosphatidylinositol (GPI)-anchored protein, confers a protective threshold against complement dysregulation which is linked to the pathogenesis of idiopathic pulmonary fibrosi
Autor:
Sundaresh Ram, Stijn E Verleden, Madhav Kumar, Alexander J. Bell, Ravi Pal, Sofie Ordies, Arno Vanstapel, Adriana Dubbeldam, Robin Vos, Stefanie Galban, Laurens J. Ceulemans, Anna E. Frick, Dirk E. Van Raemdonck, Johny Verschakelen, Bart M. Vanaudenaerde, Geert M. Verleden, Vibha N Lama, Arne P. Neyrinck, Craig J. Galban
Publikováno v:
medRxiv
BackgroundAssessment and selection of donor lungs remains largely subjective and experience based. Criteria to accept or decline lungs are poorly standardized and are not compliant with the current donor pool. Using ex vivo CT images, we investigated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1eb9599c1e7afb23db89ea0fb06884d
https://doi.org/10.1101/2023.03.28.23287705
https://doi.org/10.1101/2023.03.28.23287705
Autor:
Seagal Teitz-Tennenbaum, Steven P. Viglianti, Ahmad Jomma, Quentin Palone, Halia Andrews, Kayla N. Selbmann, Shayanki Lahiri, Natalia Subbotina, Natalie Walker, Anne-Karina T. Perl, Vibha N. Lama, Thomas H. Sisson, John J. Osterholzer
Publikováno v:
Am J Pathol
Histopathologic evidence of deployment-related constrictive bronchiolitis (DRCB) has been identified in soldiers deployed to Southwest Asia. While inhalational injury to the airway epithelium is suspected, relatively little is known about the pathoge
Autor:
David S. Wheeler, Yoshiro Aoki, Michael P. Combs, K. Misumi, Ragini Vittal, N.M. Walker, Russell R. Braeuer, Vibha N. Lama
Publikováno v:
Am J Transplant
Histopathologic examination of lungs afflicted by chronic lung allograft dysfunction (CLAD) consistently shows both mononuclear cell (MNC) inflammation and mesenchymal cell (MC) fibroproliferation. We hypothesize that interleukin 6 (IL-6) trans-signa
Autor:
Vibha N. Lama, Michael P. Combs, N.M. Walker, John R. Erb-Downward, Robert P. Dickson, Nicole R. Falkowski, David S. Wheeler, J. Luth
Publikováno v:
Lancet Respir Med
Summary Background Alterations in the respiratory microbiome are common in chronic lung diseases, correlate with decreased lung function, and have been associated with disease progression. The clinical significance of changes in the respiratory micro
Autor:
Mary K. Porteous, David J. Lederer, Laurel Kalman, Elana J. Bernstein, Michelle Oyster, Jason D. Christie, Pali D. Shah, Jonathan P. Singer, Chadi A. Hage, Joshua M. Diamond, Jonathan B. Orens, Laurie D. Snyder, Edward Cantu, Keith M. Wille, Jake G. Natalini, Steven M. Kawut, Vibha N. Lama, John F. McDyer, Ann Weinacker, Lorraine B. Ware
Publikováno v:
J Heart Lung Transplant
Background Previous studies have reported similarities in long-term outcomes following lung transplantation for connective tissue disease-associated interstitial lung disease (CTD-ILD) and idiopathic pulmonary fibrosis (IPF). However, it is unknown w