Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Vibeke Aarup"'
Autor:
Alexander Jessen, Torsten Bove, Tomasz Zawada, Susi Soegaard, Vibeke Aarup, Mattia Poli, Jørgen Serup
Publikováno v:
Skin Research and Technology. 26:241-254
Background High-intensity focused ultrasound (HIFU) operating at 20 MHz is new and applicable to skin. Details of use and instrumentation are not documented. Materials and methods A GLP compliant 12-week study of Gottingen minipigs (n = 3) was undert
A Locked Nucleic Acid Oligonucleotide Targeting MicroRNA 122 Is Well-Tolerated in Cynomolgus Monkeys
Autor:
Elisabeth S. Hildebrandt-Eriksen, Henrik Frydenlund Hansen, Vibeke Aarup, Martin E. Munk, Henrik Ørum, Robert Persson
Publikováno v:
Nucleic Acid Therapeutics. 22:152-161
MicroRNA 122 (miR-122) is liver specific, fine-tunes lipid metabolism, and is required for hepatitis C virus (HCV) abundance. Miravirsen, an oligonucleotide with locked nucleic acid, binds to miR-122, potently inhibiting its activity. We aimed at det
Autor:
Niels Fisker, Ellen Marie Straarup, Henrik Ørum, Henrik Frydenlund Hansen, Christoph Rosenbohm, Jens Bo Hansen, Vibeke Aarup, Troels Koch, Marie Lindholm, Maj Hedtjärn
Publikováno v:
Nucleic Acids Research
The potency and specificity of locked nucleic acid (LNA) antisense oligonucleotides was investigated as a function of length and affinity. The oligonucleotides were designed to target apolipoprotein B (apoB) and were investigated both in vitro and in