Whole-genome sequencing uncovers two loci for coronary artery calcification and identifies ARSE as a regulator of vascular calcification.

Autor: de Vries PS; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Conomos MP; Genetic Analysis Center, Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA., Singh K; Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Nicholson CJ; Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Jain D; Genetic Analysis Center, Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA., Hasbani NR; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Jiang W; Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Lee S; Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Lino Cardenas CL; Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Lutz SM; PRecisiOn Medicine Translational Research (PROMoTeR) Center, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Wong D; Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Yao J; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Young EP; Cardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA., Tcheandjieu C; VA Palo Alto Healthcare System, Palo Alto, CA, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Hilliard AT; VA Palo Alto Healthcare System, Palo Alto, CA, USA.; Palo Alto Veterans Institute for Research, Palo Alto, CA, USA., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Bielak LF; School of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA., Brown MR; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Musharoff S; VA Palo Alto Healthcare System, Palo Alto, CA, USA.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Clarke SL; VA Palo Alto Healthcare System, Palo Alto, CA, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Terry JG; Department of Radiology, Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University Medical Center, Nashville, TN, USA., Palmer ND; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Yanek LR; Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Xu H; Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Heard-Costa N; Boston University School of Medicine, Boston, MA, USA.; Boston University and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA, USA., Wessel J; Department of Epidemiology, Fairbanks School of Public Health, Indiana University, Indianapolis, IN, USA.; Diabetes Translational Research Center, Indiana University, Indianapolis, IN, USA., Selvaraj MS; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Li RH; Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Sun X; School of Public Health and Tropical Medicine, Department of Epidemiology, Tulane University, New Orleans, LA, USA.; College of Medicine, Department of Medicine, Division of Nephrology, University of Illinois Chicago, Chicago, IL, USA., Turner AW; Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA., Stilp AM; Genetic Analysis Center, Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA., Khan A; Genetic Analysis Center, Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA., Newman AB; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Rasheed A; Center For Non-Communicable Diseases, Karachi, Pakistan., Freedman BI; Section on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA., Kral BG; Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., McHugh CP; Genetic Analysis Center, Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA., Hodonsky C; Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA., Saleheen D; Center For Non-Communicable Diseases, Karachi, Pakistan.; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.; Department of Cardiology, Columbia University Irving Medical Center, New York, NY, USA., Herrington DM; Department of Internal Medicine, Section of Cardiovascular Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA., Jacobs DR Jr; Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA., Nickerson DA; Department of Genome Sciences, University of Washington, Seattle, WA, USA.; Northwest Genomics Center, University of Washington, Seattle, WA, USA., Boerwinkle E; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Wang FF; Genetic Analysis Center, Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA., Heiss G; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA., Jun G; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Kinney GL; Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Sigurslid HH; Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Doddapaneni H; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Hall IM; Yale Center for Genomic Health, Yale School of Medicine, New Haven, CT, USA., Bensenor IM; Center for Clinical and Epidemiological Research, University Hospital, University of Sao Paulo Medical School, São Paulo, Brazil., Broome J; Genetic Analysis Center, Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA., Crapo JD; Department of Medicine, National Jewish Health, Denver, CO, USA., Wilson JG; Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA., Smith JA; School of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Blangero J; Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Vargas JD; Medstar Heart and Vascular Institute, Medstar Georgetown University Hospital, Washington, DC, USA., Mosquera JV; Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA., Smith JD; Department of Genome Sciences, University of Washington, Seattle, WA, USA.; Northwest Genomics Center, University of Washington, Seattle, WA, USA., Viaud-Martinez KA; Illumina Laboratory Services, Illumina Inc., San Diego, CA, USA., Ryan KA; Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Young KA; Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Lange LA; Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA., Emery LS; Genetic Analysis Center, Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA., Bittencourt MS; Center for Clinical and Epidemiological Research, University Hospital, University of Sao Paulo Medical School, São Paulo, Brazil., Budoff MJ; Department of Medicine, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Montasser ME; Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Yu M; School of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA., Mahaney MC; Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Mahamdeh MS; Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Fornage M; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.; Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA., Franceschini N; Department of Epidemiology, Gillings School of Global Public health, University of North Carolina, Chapel Hill, NC, USA., Lotufo PA; Center for Clinical and Epidemiological Research, University Hospital, University of Sao Paulo Medical School, São Paulo, Brazil., Natarajan P; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Wong Q; Genetic Analysis Center, Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA., Mathias RA; Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Gibbs RA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Do R; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Mehran R; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Tracy RP; Department of Pathology and Laboratory Medicine, Robert Larner, M.D. College of Medicine, University of Vermont, Burlington, VT, USA., Kim RW; Psomagen Inc., Rockville, MD, USA., Nelson SC; Genetic Analysis Center, Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA., Damrauer SM; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Kardia SLR; School of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA., Rich SS; Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA., Fuster V; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.; Mount Sinai Heart Center, New York, NY, USA., Napolioni V; Genomic And Molecular Epidemiology (GAME) Lab, School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy., Zhao W; School of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA., Tian W; Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Yin X; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Min YI; Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA., Manning AK; Clinical and Translation Epidemiology Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Programs in Metabolism and Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Peloso G; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Kelly TN; College of Medicine, Department of Medicine, Division of Nephrology, University of Illinois Chicago, Chicago, IL, USA., O'Donnell CJ; VA Boston Healthcare System, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Morrison AC; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Curran JE; Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Zapol WM; Department of Anesthesia, Critical Care and Pain Medicine at Massachusetts General Hospital, Boston, MA, USA., Bowden DW; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Becker LC; Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Correa A; Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.; Department of Population Health Science, University of Mississippi Medical Center, Jackson, MS, USA., Mitchell BD; Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Health Services, University of Washington, Seattle, WA, USA., Carr JJ; Department of Radiology, Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University Medical Center, Nashville, TN, USA., Pereira AC; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of São Paulo, São Paulo, Brazil., Assimes TL; VA Palo Alto Healthcare System, Palo Alto, CA, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Stitziel NO; Cardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA., Hokanson JE; Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Laurie CA; Genetic Analysis Center, Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Vasan RS; Boston University and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA, USA.; Department of Medicine, Boston University School of Medicine, Boston, MA, USA.; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA., Post WS; Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Peyser PA; School of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA., Miller CL; Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA., Malhotra R; Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Publikováno v: Nature cardiovascular research [Nat Cardiovasc Res] 2023 Dec; Vol. 2 (12), pp. 1159-1172. Date of Electronic Publication: 2023 Dec 04.

Rare variants in long non-coding RNAs are associated with blood lipid levels in the TOPMed whole-genome sequencing study.

Autor: Wang Y; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Selvaraj MS; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA., Li X; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Li Z; School of Mathematics and Statistics, Northeast Normal University, Changchun, Jilin, China; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Holdcraft JA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Arnett DK; Provost Office, University of South Carolina, Columbia, SC, USA; Department of Epidemiology and Biostatistics, University of South Carolina Arnold School of Public Health, Columbia, SC, USA., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Blangero J; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Boerwinkle E; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Bowden DW; Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Cade BE; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA., Carlson JC; Department of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA; Department of Biostatistics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Carson AP; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA., Chen YI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Curran JE; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., de Vries PS; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Dutcher SK; The McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA., Ellinor PT; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Floyd JS; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA., Fornage M; Center for Human Genetics, University of Texas Health at Houston, Houston, TX, USA., Freedman BI; Department of Internal Medicine, Nephrology, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Gabriel S; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Germer S; New York Genome Center, New York, NY, USA., Gibbs RA; Baylor College of Medicine Human Genome Sequencing Center, Houston, TX, USA., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., He J; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA; Tulane University Translational Science Institute, New Orleans, LA, USA., Heard-Costa N; Framingham Heart Study, Framingham, MA, USA; Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Hildalgo B; Department of Epidemiology, University of Alabama at Birmingham School of Public Health, Birmingham, AL, USA., Hou L; Department of Preventive Medicine, Northwestern University, Chicago, IL, USA., Irvin MR; Department of Epidemiology, University of Alabama at Birmingham School of Public Health, Birmingham, AL, USA., Joehanes R; Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Kaplan RC; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA., Kardia SL; Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA., Kelly TN; Department of Medicine, Division of Nephrology, University of Illinois Chicago, Chicago, IL, USA., Kim R; Psomagen, Inc. (formerly Macrogen USA), Rockville, MD, USA., Kooperberg C; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA., Kral BG; GeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Levy D; Framingham Heart Study, Framingham, MA, USA; Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Li C; Tulane University Translational Science Institute, New Orleans, LA, USA; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA., Liu C; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA; Framingham Heart Study, Framingham, MA, USA., Lloyd-Jone D; Department of Preventive Medicine, Northwestern University, Chicago, IL, USA., Loos RJ; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA; NNF Center for Basic Metabolic Research, University of Copenhagen, Cophenhagen, Denmark., Mahaney MC; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Martin LW; George Washington University School of Medicine and Health Sciences, Washington, DC, USA., Mathias RA; GeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Minster RL; Department of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Mitchell BD; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Montasser ME; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Morrison AC; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Murabito JM; Framingham Heart Study, Framingham, MA, USA; Department of Medicine, Boston Medical Center, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA., Naseri T; Naseri & Associates Public Health Consultancy Firm and Family Health Clinic, Apia, Samoa; International Health Institute, School of Public Health, Brown University, Providence, RI, USA., O'Connell JR; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Palmer ND; Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Preuss MH; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA; Department of Health Systems and Population Health, University of Washington, Seattle, WA, USA., Raffield LM; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Rao DC; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA., Redline S; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Reiner AP; Department of Epidemiology, University of Washington, Seattle, WA, USA., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Ruepena MS; Lutia i Puava ae Mapu i Fagalele, Apia, Samoa., Sheu WH; Institute of Molecular and Genomic Medicine, National Health Research Institute (NHRI), Miaoli County, Taiwan., Smith JA; Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA., Smith A; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA., Tiwari HK; Department of Biostatistics, University of Alabama, Birmingham, AL, USA., Tsai MY; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA., Viaud-Martinez KA; Illumina Laboratory Services, Illumina Inc., San Diego, CA, USA., Wang Z; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Yanek LR; GeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Zhao W; Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Lin X; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Statistics, Harvard University, Cambridge, MA, USA., Natarajan P; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA., Peloso GM; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. Electronic address: gpeloso@bu.edu.

Publikováno v: American journal of human genetics [Am J Hum Genet] 2023 Oct 05; Vol. 110 (10), pp. 1704-1717.

Past Connectivity but Recent Inbreeding in Cross River Gorillas Determined Using Whole Genomes from Single Hairs.

Autor: Alvarez-Estape M; Institute of Evolutionary Biology (UPF-CSIC), PRBB, c/ del Dr. Aiguader 88, 08003 Barcelona, Spain., Pawar H; Institute of Evolutionary Biology (UPF-CSIC), PRBB, c/ del Dr. Aiguader 88, 08003 Barcelona, Spain., Fontsere C; Institute of Evolutionary Biology (UPF-CSIC), PRBB, c/ del Dr. Aiguader 88, 08003 Barcelona, Spain.; Center for Evolutionary Hologenomics, The Globe Institute, University of Copenhagen, Øster Farimagsgade 5A, 1352 Copenhagen, Denmark., Trujillo AE; Department of Anthropology, New York University, New York, NY 10003, USA.; New York Consortium in Evolutionary Primatology, New York, NY 10065, USA., Gunson JL; Department of Anthropology, New York University, New York, NY 10003, USA.; New York Consortium in Evolutionary Primatology, New York, NY 10065, USA., Bergl RA; Conservation, Education and Science Department, North Carolina Zoo, Asheboro, NC 27205, USA., Bermejo M; SPAC Scientific Field Station Network, Hasso Plattner Foundation (HPF), 14467 Potsdam, Germany.; Department of Ecology and Environmental Sciences, University of Barcelona, 08028 Barcelona, Spain., Linder JM; Department of Anthropology, James Madison University, Harrisonburg, VA 22807, USA., McFarland K; Triton College, River Grove, IL 60171, USA., Oates JF; Department of Anthropology, Hunter College, City University of New York, New York, NY 10065, USA., Sunderland-Groves JL; Department of Forest Resources Management, University of British Columbia, Vancouver, BC V6T 1Z4, Canada., Orkin J; Institute of Evolutionary Biology (UPF-CSIC), PRBB, c/ del Dr. Aiguader 88, 08003 Barcelona, Spain.; Department of Anthropology, Montreal University, Montreal, QC H3T 1N8, Canada., Higham JP; Department of Anthropology, New York University, New York, NY 10003, USA., Viaud-Martinez KA; Illumina Laboratory Services, Illumina Inc., 5200 Illumina Way, San Diego, CA 92122, USA., Lizano E; Institute of Evolutionary Biology (UPF-CSIC), PRBB, c/ del Dr. Aiguader 88, 08003 Barcelona, Spain.; Institut Català de Paleontologia Miquel Crusafont, Universitat Autònoma de Barcelona, Edifici ICTA-ICP, Cerdanyola del Vallès, 08193 Barcelona, Spain., Marques-Bonet T; Institute of Evolutionary Biology (UPF-CSIC), PRBB, c/ del Dr. Aiguader 88, 08003 Barcelona, Spain.; Institut Català de Paleontologia Miquel Crusafont, Universitat Autònoma de Barcelona, Edifici ICTA-ICP, Cerdanyola del Vallès, 08193 Barcelona, Spain.; Catalan Institution of Research and Advanced Studies (ICREA), Passeig de Lluís Companys, 23, 08010 Barcelona, Spain.; CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology, Baldiri i Reixac 4, 08028 Barcelona, Spain.

Publikováno v: Genes [Genes (Basel)] 2023 Mar 18; Vol. 14 (3). Date of Electronic Publication: 2023 Mar 18.

Structural variation across 138,134 samples in the TOPMed consortium.

Autor: Jun G; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston., English AC; Baylor College of Medicine Human Genome Sequencing Center, Houston, TX, USA., Metcalf GA; Baylor College of Medicine Human Genome Sequencing Center, Houston, TX, USA., Yang J; University of Southern California, Los Angeles, CA, USA., Chaisson MJ; University of Southern California, Los Angeles, CA, USA., Pankratz N; University of Minnesota, Minneapolis, MN, USA., Menon VK; Baylor College of Medicine Human Genome Sequencing Center, Houston, TX, USA., Salerno WJ; Regeneron Genetics Center., Krasheninina O; Regeneron Genetics Center., Smith AV; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI., Lane JA; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI., Blackwell T; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI., Kang HM; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI., Salvi S; Baylor College of Medicine Human Genome Sequencing Center, Houston, TX, USA., Meng Q; Baylor College of Medicine Human Genome Sequencing Center, Houston, TX, USA., Shen H; Baylor College of Medicine Human Genome Sequencing Center, Houston, TX, USA., Pasham D; Baylor College of Medicine Human Genome Sequencing Center, Houston, TX, USA., Bhamidipati S; Baylor College of Medicine Human Genome Sequencing Center, Houston, TX, USA., Kottapalli K; Baylor College of Medicine Human Genome Sequencing Center, Houston, TX, USA., Arnett DK; Department of Epidemiology, University of Kentucky College of Public Health., Ashley-Koch A; Department of Medicine, Duke University Medical Center, Durham, NC.; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC., Auer PL; Division of Biostatistics and Cancer Center, Medical College of Wisconsin, Milwaukee WI., Beutel KM; University of Minnesota, Minneapolis, MN, USA., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Blangero J; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas, Rio Grande Valley School of Medicine, Brownsville, TX., Bowden DW; Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Cade BE; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA., Chen YI; Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center.; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA USA., Cho MH; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA., Curran JE; Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Fornage M; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX., Freedman BI; Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, NC, USA., Fingerlin T; Center for Genes, Environment and Health, National Jewish Health, 1400 Jackson St., Denver, CO, 80206, USA., Gelb BD; Mindich Child Health and Development Institute and the Departments of Pediatrics and Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai., Hou L; Northwestern University, Chicago, IL., Hung YJ; Institute of Preventive Medicine, National Defense Medical Center, Taiwan., Kane JP; Cardiovascular Research Institute, University of California, San Francisco., Kaplan R; Department of epidemiology and population health, Albert Einstein College of Medicine, Bronx NY USA., Kim W; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY., Marcus GM; Division of Cardiology, University of California, San Francisco CA., Mathias RA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD., McGarvey ST; Department of Epidemiology, International Health Institute and Department of Anthropology, Brown University., Montgomery C; Genes and Human Disease Research Program, Oklahoma Medical Research Foundation., Naseri T; Ministry of Health, Government of Samoa, Apia, Samoa., Nouraie SM; Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213., Preuss MH; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY., Palmer ND; Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI USA., Raffield LM; Department of Genetics, University of North Carolina at Chapel Hill., Ratan A; Center for Public Health Genomics, University of Virginia, Charlottesville, VA USA., Redline S; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA., Reupena S; Lutia i Puava ae Mapu i Fagalele, Apia, Samoa 663030., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA USA.; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Rich SS; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI USA., Rienstra M; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Ruczinski I; Department of Biostatistics, Johns Hopkins University Bloomberg, School of Public Health, Baltimore, MD, USA., Sankaran VG; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115.; Broad Institute of MIT and Harvard, Cambridge, MA 02142., Schwartz DA; University of Colorado Department of Medicine., Seidman CE; Department of Genetics, Harvard Medical School.; Cardiovascular Division, Brigham & Women's Hospital, Harvard University.; Howard Hughes Medical Institute, Harvard University., Seidman JG; Department of Genetics, Harvard Medical School., Silverman EK; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA., Smith JA; Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213., Stilp A; Department of Biostatistics, University of Washington, Seattle, WA., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA USA.; Center for Public Health Genomics, University of Virginia, Charlottesville, VA USA., Telen MJ; Department of Medicine, Duke University Medical Center, Durham, NC., Weiss ST; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Williams LK; Center for Individualized and Genomic Medicine Research (CIGMA), Department of Internal Medicine, Henry Ford Health System, Detroit, Michigan, United States of America., Wu B; Center for Individualized and Genomic Medicine Research (CIGMA), Department of Internal Medicine, Henry Ford Health System, Detroit, Michigan, United States of America., Yanek LR; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY., Zhang Y; Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213., Lasky-Su J; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Gingras MC; Baylor College of Medicine Human Genome Sequencing Center, Houston, TX, USA., Dutcher SK; Department of Genetics, Washington University School of Medicine, Saint Louis, MO 63110, USA., Eichler EE; Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, Washington, USA., Gabriel S; Broad Institute of MIT and Harvard, Cambridge, MA 02142., Germer S; New York Genome Center, New York, NY, USA., Kim R; Psomagen, Inc.,Rockville, Maryland, USA., Viaud-Martinez KA; Illumina Laboratory Services, Illumina, Inc., San Diego., Nickerson DA; Department of Genome Sciences, University of Washington, Seattle, WA 98195., Luo J; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Reiner A; Department of Epidemiology, University of Washington, Seattle, WA 98109, USA., Gibbs RA; Baylor College of Medicine Human Genome Sequencing Center, Houston, TX, USA., Boerwinkle E; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston.; Baylor College of Medicine Human Genome Sequencing Center, Houston, TX, USA., Abecasis G; Regeneron Genetics Center.; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI., Sedlazeck FJ; Baylor College of Medicine Human Genome Sequencing Center, Houston, TX, USA.; Department of Computer Science, Rice University, 6100 Main Street, Houston, TX, 77005, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jan 25. Date of Electronic Publication: 2023 Jan 25.

Whole genome sequence analysis of blood lipid levels in >66,000 individuals.

Autor: Selvaraj MS; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, 02114, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA., Li X; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA., Li Z; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA., Pampana A; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA., Zhang DY; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Park J; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Aslibekyan S; Department of Epidemiology, University of Alabama at Birmingham School of Public Health, Birmingham, AL, USA., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Cade BE; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Chuang LM; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan., Chung RH; Institute of Population Health Sciences, National Health Research Institutes, Zhunan, 350, Taiwan., Curran JE; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, 78520, USA., de las Fuentes L; Department of Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, MO, USA.; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA., de Vries PS; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Duggirala R; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, 78520, USA., Freedman BI; Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA., Graff M; Department of Epidemiology, UNC Chapel Hill, Chapel Hill, NC, USA., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Heard-Costa N; Department of Neurology, Boston university School of Medicine, Boston, MA, USA., Hidalgo B; Department of Epidemiology, University of Alabama at Birmingham School of Public Health, Birmingham, AL, USA., Hwu CM; Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan., Irvin MR; Department of Epidemiology, University of Alabama at Birmingham School of Public Health, Birmingham, AL, USA., Kelly TN; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, 70112, USA.; Tulane University Translational Science Institute, New Orleans, LA, 70112, USA., Kral BG; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Lange L; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Li X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Lisa M; Department of Medicine, George Washington University, Washingron, DC, USA., Lubitz SA; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, 02114, USA.; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, 02124, USA., Manichaikul AW; Department of Public Health Sciences, Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Michael P; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Montasser ME; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Morrison AC; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Naseri T; Ministry of Health, Government of Samoa, Samoa, USA., O'Connell JR; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Palmer ND; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA., Peyser PA; Department of Epidemiology, University of Michigan, Ann Arbor, MI, 48109, USA., Reupena MS; Lutia i Puava ae Mapu i Fagalele, Apia, Samoa., Smith JA; Department of Epidemiology, University of Michigan, Ann Arbor, MI, 48109, USA., Sun X; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, 70112, USA., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Tracy RP; Departments of Pathology & Laboratory Medicine and Biochemistry, Larner College of Medicine at the University of Vermont, Colchester, VT, USA., Tsai MY; Department of Laboratory Medicine and Pathology, University of Minneosta, Minneapolis, MN, USA., Wang Z; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Wang Y; Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA., Bao W; Institute of Public Health, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230026, China., Wilkins JT; Department of Medicine (Cardiology) and Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Yanek LR; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Zhao W; Department of Epidemiology, University of Michigan, Ann Arbor, MI, 48109, USA., Arnett DK; Dean's Office, University of Kentucky College of Public Health, Lexington, KY, USA., Blangero J; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, 78520, USA., Boerwinkle E; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Bowden DW; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA., Chen YI; Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Correa A; Department of Population Health Science, University of Mississippi Medical Center, Jackson, MS, USA., Cupples LA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA., Dutcher SK; The McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, 63108, USA., Ellinor PT; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, 02114, USA.; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, 02124, USA., Fornage M; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, 7722, USA., Gabriel S; Broad Institute, Cambridge, MA, 02142, USA., Germer S; New York Genome Center, New York, NY, 10013, USA., Gibbs R; Baylor College of Medicine Human Genome Sequencing Center, Houston, TX, 77030, USA., He J; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, 70112, USA.; Tulane University Translational Science Institute, New Orleans, LA, 70112, USA., Kaplan RC; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA., Kardia SLR; Department of Epidemiology, University of Michigan, Ann Arbor, MI, 48109, USA., Kim R; Psomagen, Inc. (formerly Macrogen USA), Rockville, MD, USA., Kooperberg C; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; NNF Center for Basic Metabolic Research, University of Copenhagen, Cophenhagen, Denmark., Viaud-Martinez KA; Illumina Laboratory Services, Illumina. Inc, San Diego, 92122, USA., Mathias RA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., McGarvey ST; Department of Epidemiology, International Health Institute, Brown University, Providence, RI, USA., Mitchell BD; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA., Nickerson D; University of Washington, Department of Genome Sciences, Seattle, WA, 98195, USA., North KE; Department of Epidemiology, UNC Chapel Hill, Chapel Hill, NC, USA., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Health Systems and Population Health, University of Washington, Seattle, WA, USA., Redline S; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Reiner AP; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Vasan RS; Sections of Preventive medicine and Epidemiology, Cardiovascular medicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.; Framingham Heart Study, Framingham, MA, USA., Rich SS; Department of Public Health Sciences, Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Willer C; University of Michigan, Internal Medicine, Ann Arbor, MI, 48109, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Rader DJ; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Lin X; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.; Department of Statistics, Harvard University, Cambridge, MA, 02138, USA., Peloso GM; Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA. gpeloso@bu.edu., Natarajan P; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, 02114, USA. pnatarajan@mgh.harvard.edu.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA. pnatarajan@mgh.harvard.edu.; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA. pnatarajan@mgh.harvard.edu.

Publikováno v: Nature communications [Nat Commun] 2022 Oct 11; Vol. 13 (1), pp. 5995. Date of Electronic Publication: 2022 Oct 11.