Enhancer-promoter interactions become more instructive in the transition from cell-fate specification to tissue differentiation.

Autor: Pollex T; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany.; European Molecular Biology Laboratory (EMBL), Directors' Research Unit, Heidelberg, Germany., Rabinowitz A; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany., Gambetta MC; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany.; Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland., Marco-Ferreres R; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany., Viales RR; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany., Jankowski A; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany.; Faculty of Mathematics, Informatics and Mechanics, University of Warsaw, Warsaw, Poland., Schaub C; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany., Furlong EEM; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany. furlong@embl.de.

Publikováno v: Nature genetics [Nat Genet] 2024 Apr; Vol. 56 (4), pp. 686-696. Date of Electronic Publication: 2024 Mar 11.

CTCF, BEAF-32, and CP190 are not required for the establishment of TADs in early Drosophila embryos but have locus-specific roles.

Autor: Cavalheiro GR; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, D-69117 Heidelberg, Baden-Württemberg, Germany.; Collaboration for Joint PhD Degree between EMBL and Heidelberg University, Faculty of Biosciences, Baden-Württemberg, Germany., Girardot C; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, D-69117 Heidelberg, Baden-Württemberg, Germany., Viales RR; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, D-69117 Heidelberg, Baden-Württemberg, Germany., Pollex T; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, D-69117 Heidelberg, Baden-Württemberg, Germany., Cao TBN; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, D-69117 Heidelberg, Baden-Württemberg, Germany., Lacour P; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, D-69117 Heidelberg, Baden-Württemberg, Germany.; École Normale Supérieure, 45 rue d'Ulm, 75005 Paris, France., Feng S; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, D-69117 Heidelberg, Baden-Württemberg, Germany., Rabinowitz A; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, D-69117 Heidelberg, Baden-Württemberg, Germany., Furlong EEM; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, D-69117 Heidelberg, Baden-Württemberg, Germany.

Publikováno v: Science advances [Sci Adv] 2023 Feb 03; Vol. 9 (5), pp. eade1085. Date of Electronic Publication: 2023 Feb 03.

Cis -acting variation is common across regulatory layers but is often buffered during embryonic development.

Autor: Floc'hlay S; Institut de Biologie de l'ENS (IBENS), École Normale Supérieure, CNRS, INSERM, Université PSL, 75005 Paris, France., Wong ES; Molecular, Structural and Computational Biology Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia.; School of Biotechnology and Biomolecular Sciences, UNSW Sydney, Kensington, New South Wales 2052, Australia., Zhao B; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, D-69117 Heidelberg, Germany., Viales RR; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, D-69117 Heidelberg, Germany., Thomas-Chollier M; Institut de Biologie de l'ENS (IBENS), École Normale Supérieure, CNRS, INSERM, Université PSL, 75005 Paris, France.; Institut Universitaire de France (IUF), 75005 Paris, France., Thieffry D; Institut de Biologie de l'ENS (IBENS), École Normale Supérieure, CNRS, INSERM, Université PSL, 75005 Paris, France., Garfield DA; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, D-69117 Heidelberg, Germany., Furlong EEM; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, D-69117 Heidelberg, Germany.

Publikováno v: Genome research [Genome Res] 2021 Feb; Vol. 31 (2), pp. 211-224. Date of Electronic Publication: 2020 Dec 11.

Identification of candidate causal variants and target genes at 41 breast cancer risk loci through differential allelic expression analysis.

Autor: Xavier, Joana M.^1,2 (AUTHOR) jgxavier@ualg.pt, Magno, Ramiro^1,3 (AUTHOR), Russell, Roslin^4,5 (AUTHOR), de Almeida, Bernardo P.^6,7,8 (AUTHOR), Jacinta-Fernandes, Ana⁶ (AUTHOR), Besouro-Duarte, André¹ (AUTHOR), Dunning, Mark^4,9 (AUTHOR), Samarajiwa, Shamith^10,11 (AUTHOR), O'Reilly, Martin⁴ (AUTHOR), Maia, António M.¹ (AUTHOR), Rocha, Cátia L.^6,12 (AUTHOR), Rosli, Nordiana^6,13,14 (AUTHOR), Ponder, Bruce A. J.⁴ (AUTHOR), Maia, Ana-Teresa^1,2,6 (AUTHOR) atmaia@ualg.pt

Publikováno v: Scientific Reports. 9/28/2024, Vol. 14 Issue 1, p1-19. 19p.

Non-coding RNA Expression, Function, and Variation during Drosophila Embryogenesis.

Autor: Schor IE; Genome Biology Unit, European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany; Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE-CONICET), Departamento de Fisiología, Biología Molecular y Celular, FCEyN, Universidad de Buenos Aires, Buenos Aires, Argentina., Bussotti G; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton CB10 1SD, UK., Maleš M; Genome Biology Unit, European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany., Forneris M; Genome Biology Unit, European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany., Viales RR; Genome Biology Unit, European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany., Enright AJ; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton CB10 1SD, UK., Furlong EEM; Genome Biology Unit, European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany. Electronic address: furlong@embl.de.

Publikováno v: Current biology : CB [Curr Biol] 2018 Nov 19; Vol. 28 (22), pp. 3547-3561.e9. Date of Electronic Publication: 2018 Nov 01.