Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Viacheslav V. Senichkin"'
Autor:
Alena Y. Streletskaia, Viacheslav V. Senichkin, Tatiana A. Prikazchikova, Timofei S. Zatsepin, Boris Zhivotovsky, Gelina S. Kopeina
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
As an important regulator of apoptosis, Mcl-1 protein, a member of the Bcl-2 family, represents an attractive target for cancer treatment. The recent development of novel small molecule compounds has allowed Mcl-1-inhibitory therapy to proceed to cli
Externí odkaz:
https://doaj.org/article/fe281dc5d1934d109ba17179daeb6267
Publikováno v:
Cells, Vol 10, Iss 4, p 852 (2021)
Subcellular fractionation approaches remain an indispensable tool among a large number of biochemical methods to facilitate the study of specific intracellular events and characterization of protein functions. During apoptosis, the best-known form of
Externí odkaz:
https://doaj.org/article/fc13622c54ad45bea30e9f6ce1e08286
Publikováno v:
Biochemistry (Moscow). 85:1210-1226
Proteins of the Bcl-2 family are known as regulators of apoptosis, one of the most studied forms of programmed cell death. The Bcl-2 protein family is represented by both pro- and antiapoptotic members. Antiapoptotic proteins are often exploited by t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12e4b1e196c01ec7adf60004768b2d37
https://doi.org/10.1134/s0006297920100090
https://doi.org/10.1134/s0006297920100090
Autor:
Kopeina, Viacheslav V. Senichkin, Nikolay V. Pervushin, Alexey V. Zamaraev, Elena V. Sazonova, Anton P. Zuev, Alena Y. Streletskaia, Tatiana A. Prikazchikova, Timofei S. Zatsepin, Olga V. Kovaleva, Elena M. Tchevkina, Boris Zhivotovsky, Gelina S.
Publikováno v:
Cancers; Volume 14; Issue 1; Pages: 181
BH3 mimetics represent a promising tool in cancer treatment. Recently, the drugs targeting the Mcl-1 protein progressed into clinical trials, and numerous studies are focused on the investigation of their activity in various preclinical models. We in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::cc769a82c9a01397dbcc4a3d8b4ffc14
Publikováno v:
Trends in Cell Biology. 29:549-562
Among cell death regulators, members of the Bcl-2 family are of interest because they are highly conserved across species and represent promising targets for anticancer therapy. This family and its associated proteins include more than 25 members, wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060fdffc54d920be5d712678f8c26c58
https://doi.org/10.1016/j.tcb.2019.03.004
https://doi.org/10.1016/j.tcb.2019.03.004
Autor:
Vitaliy O. Kaminskyy, Gelina S. Kopeina, Boris Zhivotovsky, A A Kapusta, Viacheslav V Senichkin, Anna S. Gorbunova, Nikolay V. Pervushin
Publikováno v:
Biochemistry. Biokhimiia. 85(10)
The antiapoptotic protein Mcl-1, which is an attractive target for cancer treatment, is degraded under nutrient deprivation conditions in different types of cancer. This process sensitizes cancer cells to chemotherapy. It has been found that nutrient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a424f08460809bb8eccc8da944054a
https://pubmed.ncbi.nlm.nih.gov/33202208
https://pubmed.ncbi.nlm.nih.gov/33202208
Publikováno v:
International review of cell and molecular biology. 351
During the last two decades, the study of Mcl-1, an anti-apoptotic member of the Bcl-2 family, attracted researchers due to its important role in cancer cell survival and tumor development. The significance of Mcl-1 protein in resistance to chemother
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8f6087dcebdc0f78128d0a1d31a998f7
https://pubmed.ncbi.nlm.nih.gov/32247581
https://pubmed.ncbi.nlm.nih.gov/32247581
During the last two decades, the study of Mcl-1, an anti-apoptotic member of the Bcl-2 family, attracted researchers due to its important role in cancer cell survival and tumor development. The significance of Mcl-1 protein in resistance to chemother
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9c6967031143a8e3c4fafcf92904fda
https://doi.org/10.1016/bs.ircmb.2020.01.002
https://doi.org/10.1016/bs.ircmb.2020.01.002
Autor:
Kadri Valter, Alibek Abdrakhmanov, Boris Zhivotovsky, Vladimir Gogvadze, Polina Maximchik, Viacheslav V Senichkin
Publikováno v:
Cellular and Molecular Life Sciences
The majority of anticancer drugs are DNA-damaging agents, and whether or not they may directly target mitochondria remains unclear. In addition, tumors such as neuroblastoma exhibit addiction to glutamine in spite of it being a nonessential amino aci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ae5e428fee52577a4bcb1b7615c5f7
https://pubmed.ncbi.nlm.nih.gov/31392350
https://pubmed.ncbi.nlm.nih.gov/31392350
Autor:
Boris Zhivotovsky, Alexey V. Zamaraev, Inna N. Lavrik, Viacheslav V Senichkin, Gelina S. Kopeina, Eugeniia A. Prokhorova
Publikováno v:
Biochimica et biophysica acta. General subjects. 1862(3)
Background The development of approaches that increase therapeutic effects of anti-cancer drugs is one of the most important tasks of oncology. Caloric restriction in vivo or serum deprivation (SD) in vitro has been shown to be an effective tool for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7b0357a98675a51f08209c6d5c3aba8
https://pubmed.ncbi.nlm.nih.gov/29203282
https://pubmed.ncbi.nlm.nih.gov/29203282