Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Viachaslau Bernat"'
Autor:
Zi-Fu, Wang, Andrei, Ursu, Jessica L, Childs-Disney, Rea, Guertler, Wang-Yong, Yang, Viachaslau, Bernat, Suzanne G, Rzuczek, Rita, Fuerst, Yong-Jie, Zhang, Tania F, Gendron, Ilyas, Yildirim, Brendan G, Dwyer, Joseph E, Rice, Leonard, Petrucelli, Matthew D, Disney
Publikováno v:
Cell chemical biology. 26(2)
The most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is an expanded G(4)C(2) repeat [(G(4)C(2))(exp)] in C9ORF72. ALS/FTD-associated toxicity has been traced to the RNA transcribed from the repeat exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::db489aeede88b88763d3b52015dafa54
https://pubmed.ncbi.nlm.nih.gov/30503283
https://pubmed.ncbi.nlm.nih.gov/30503283
Publikováno v:
ChemMedChem. 10:566-574
Over the last decade, functional selectivity (or ligand bias) has evolved from being a peculiar phenomenon to being recognized as an essential feature of synthetic ligands that target G protein-coupled receptors (GPCRs). The CXC chemokine receptor 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdb2f9b24752a2a336ce1810fba73104
https://doi.org/10.1002/cmdc.201402507
https://doi.org/10.1002/cmdc.201402507
Identifying Modulators of CXC Receptors 3 and 4 with Tailored Selectivity Using Multi-Target Docking
Publikováno v:
ACS Chemical Biology. 10:715-724
The G protein-coupled receptors of the C-X-C subfamily form a group among the chemokine receptors whose endogenous ligands are peptides with a common Cys-X-Cys motif. The CXC chemokine receptors 3 and 4 (CXCR3, CXCR4), which are investigated in this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce54538861cc367450ccd039a11c925f
https://doi.org/10.1021/cb500577j
https://doi.org/10.1021/cb500577j
Publikováno v:
ACS Chemical Biology. 9:2664-2677
The chemokine receptor CXCR3 is a G protein-coupled receptor, which conveys extracellular signals into cells by changing its conformation upon agonist binding. To facilitate the mechanistic understanding of allosteric modulation of CXCR3, we combined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060c83d3957e468e6aa80d1c5b346ac1
https://doi.org/10.1021/cb500678c
https://doi.org/10.1021/cb500678c
Autor:
Tania F. Gendron, Brendan G. Dwyer, Joseph E. Rice, Rea Guertler, Rita Fuerst, Matthew D. Disney, Wang Yong Yang, Yong Jie Zhang, Viachaslau Bernat, Leonard Petrucelli, Andrei Ursu, Zi-Fu Wang, Ilyas Yildirim, Jessica L. Childs-Disney, Suzanne G. Rzuczek
Publikováno v:
Cell Chemical Biology. 26:179-190.e12
Summary The most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is an expanded G4C2 repeat [(G4C2)exp] in C9ORF72. ALS/FTD-associated toxicity has been traced to the RNA transcribed from the repeat expan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef0b11fe13bb972db023d5e9b322d441
https://doi.org/10.1016/j.chembiol.2018.10.018
https://doi.org/10.1016/j.chembiol.2018.10.018
Publikováno v:
ChemMedChem. 11(6)
The CXCR3 receptor, a class A G protein-coupled receptor (GPCR), is involved in the regulation and trafficking of various immune cells. CXCR3 antagonists have been proposed to be beneficial for the treatment of a wide range of disorders including but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02b46480cda06bcdd8f80b45c162bbd7
https://pubmed.ncbi.nlm.nih.gov/26880380
https://pubmed.ncbi.nlm.nih.gov/26880380
Autor:
Peter Gmeiner, Brian K. Kobilka, Viachaslau Bernat, Henry Lin, Dipendra K. Aryal, Da Duan, Gregory Corder, Brian K. Shoichet, Aashish Manglik, Ralf C. Kling, Anat Levit, Bryan L. Roth, Maria F. Sassano, Xi Ping Huang, Stefan Löber, Harald Hübner, John D. McCorvy, Grégory Scherrer, Daniela Dengler, Patrick M. Giguère
Publikováno v:
Nature. 537(7619)
Morphine is an alkaloid from the opium poppy used to treat pain. The potentially lethal side effects of morphine and related opioids-which include fatal respiratory depression-are thought to be mediated by μ-opioid-receptor (μOR) signalling through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f497b8af1eb977e081749f1e7fdb4d92
https://pubmed.ncbi.nlm.nih.gov/27533037
https://pubmed.ncbi.nlm.nih.gov/27533037
Publikováno v:
ChemMedChem. 7(8)
Strategies for the identification of allosteric modulators of chemokine receptors largely rely on various cell-based functional assays. Radioligand binding assays are typically not available for allosteric binding sites. We synthesized, purified, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07555de5e611a10df6046a678de17b80
https://pubmed.ncbi.nlm.nih.gov/22689503
https://pubmed.ncbi.nlm.nih.gov/22689503
Autor:
Viachaslau Bernat, Matthew D. Disney
Publikováno v:
Neuron. (1):28-46
RNAs adopt diverse folded structures that are essential for function and thus play critical roles in cellular biology. A striking example of this is the ribosome, a complex, three-dimensionally folded macromolecular machine that orchestrates protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7fbbdbeca8cdbed7df2c332a3dc7705